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Antibiotics, Volume 12, Issue 8

August 2023 - 118 articles

Cover Story: Amphiphilic tobramycins are an emerging class of antibiotic potentiators against Gram-negative bacteria, including Pseudomonas aeruginosa. To study how the antibiotic-potentiating effect of amphiphilic tobramycins is affected by the presence of intermolecular iron chelators, we conjugated the FDA-approved iron chelator deferiprone (DEF) to tobramycin (TOB). While TOB-DEF conjugates were inactive against P. aeruginosa, all TOB-DEF conjugates strongly synergized with outer-membrane-impermeable antibiotics. The optimized conjugate displayed selective and synergistic potentiation of tetracycline antibiotics against multidrug-resistant P. aeruginosa isolates. However, the tetracycline-potentiating effect of the conjugate is independent of the Fe3+-complexing properties and is the result of enhanced outer membrane permeability. View this paper
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Articles (118)

  • Article
  • Open Access
11 Citations
3,532 Views
11 Pages

The objective of this study was to evaluate collateral sensitivity and cross-resistance of antibiotic-induced resistant Salmonella Typhimurium to various antibiotics. S. Typhimurium ATCC 19585 (STWT) was exposed to ciprofloxacin, gentamicin, kanamyci...

  • Feature Paper
  • Article
  • Open Access
5 Citations
3,232 Views
14 Pages

Antimicrobial Effect of Low-Fluoride Toothpastes Containing Polyphosphate and Polyols: An In Vitro Assessment of Inhibition Zones

  • Igor Zen,
  • Alberto Carlos Botazzo Delbem,
  • Thayse Yumi Hosida,
  • Caio Sampaio,
  • Leonardo Antônio de Morais,
  • Tamires Passadori Martins,
  • Douglas Roberto Monteiro and
  • Juliano Pelim Pessan

This study evaluated the antimicrobial effect of toothpastes containing 200 ppm fluoride (200F), xylitol (X, 16%), erythritol (E, 4%), and sodium trimetaphosphate (TMP, 0.25%), alone or in different associations, against Streptococcus mutans (SM), La...

  • Review
  • Open Access
8 Citations
3,828 Views
17 Pages

Managing Corneal Infections: Out with the old, in with the new?

  • Sanjay Marasini,
  • Jennifer P. Craig,
  • Simon J. Dean and
  • Leon G. Leanse

There have been multiple reports of eye infections caused by antibiotic-resistant bacteria, with increasing evidence of ineffective treatment outcomes from existing therapies. With respect to corneal infections, the most commonly used antibiotics (fl...

  • Article
  • Open Access
14 Citations
3,774 Views
17 Pages

Exploring the Multifaceted Potential of a Peptide Fraction Derived from Saccharomyces cerevisiae Metabolism: Antimicrobial, Antioxidant, Antidiabetic, and Anti-Inflammatory Properties

  • Patrícia Branco,
  • Elisabete Muchagato Maurício,
  • Ana Costa,
  • Diogo Ventura,
  • Catarina Roma-Rodrigues,
  • Maria Paula Duarte,
  • Alexandra R. Fernandes and
  • Catarina Prista

The rising demand for minimally processed, natural, and healthier food products has led to the search for alternative and multifunctional bioactive food components. Therefore, the present study focuses on the functional proprieties of a peptide fract...

  • Article
  • Open Access
10 Citations
3,397 Views
16 Pages

Antimicrobial Activity and Molecular Docking Studies of the Biotransformation of Diterpene Acanthoic Acid Using the Fungus Xylaria sp.

  • Andrey Moacir do Rosario Marinho,
  • Claudia Maria S. C. de Oliveira,
  • João Victor Silva-Silva,
  • Samara C. Anchieta de Jesus,
  • José Edson S. Siqueira,
  • Luana C. de Oliveira,
  • Jéssica Fernandes Auzier,
  • Liviane N. Soares,
  • Maria Lúcia Belém Pinheiro and
  • Sebastião C. Silva
  • + 3 authors

Biotransformations are reactions mediated by microorganisms, such as fungi. These bioreactions have high chemo- and stereoselectivity on organic substrates and can be applied in the search for new bioactive compounds. In this study, acanthoic acid (A...

  • Feature Paper
  • Article
  • Open Access
12 Citations
5,057 Views
18 Pages

Multidrug-Resistant Salmonella Species and Their Mobile Genetic Elements from Poultry Farm Environments in Malaysia

  • Syahidiah Syed Abu Thahir,
  • Sakshaleni Rajendiran,
  • Rafiza Shaharudin and
  • Yuvaneswary Veloo

The prevalence and persistent outbreaks of multidrug-resistant (MDR) Salmonella in low-income countries have received growing attention among the public and scientific community. Notably, the excessive use of antibiotics in chicken feed for the purpo...

  • Review
  • Open Access
44 Citations
9,621 Views
17 Pages

The Potential of Bacteriophage-Antibiotic Combination Therapy in Treating Infections with Multidrug-Resistant Bacteria

  • Abdul-Halim Osman,
  • Fleischer C. N. Kotey,
  • Alex Odoom,
  • Samuel Darkwah,
  • Raphael K. Yeboah,
  • Nicholas T. K. D. Dayie and
  • Eric S. Donkor

The growing threat of antibiotic resistance is a significant global health challenge that has intensified in recent years. The burden of antibiotic resistance on public health is augmented due to its multifaceted nature, as well as the slow-paced and...

  • Case Report
  • Open Access
6 Citations
4,017 Views
9 Pages

Ceftazidime-Avibactam as Osteomyelitis Therapy: A Miniseries and Review of the Literature

  • Alessandro Mancuso,
  • Luca Pipitò,
  • Raffaella Rubino,
  • Salvatore Antonino Distefano,
  • Donatella Mangione and
  • Antonio Cascio

Bone and joint infections (BJIs) caused by multidrug-resistant gram-negative bacteria are becoming a concern due to limited therapeutic options. Although not approved for these indications, an ever-growing amount of evidence supports the efficacy and...

  • Review
  • Open Access
34 Citations
6,257 Views
16 Pages

Enterococci are often used in probiotics but can also cause nosocomial infections. As such, enterococcal consumption may have beneficial health effects, but a thorough evaluation of virulence absence and risk of antibiotic resistance spread is needed...

  • Article
  • Open Access
9 Citations
3,375 Views
12 Pages

Enhancing Chemical Stability through Structural Modification of Antimicrobial Peptides with Non-Proteinogenic Amino Acids

  • Takahito Ito,
  • Natsumi Matsunaga,
  • Megumi Kurashima,
  • Yosuke Demizu and
  • Takashi Misawa

Multidrug-resistant bacteria (MDRB) remain a significant threat to humanity, resulting in over 1.2 million deaths per year. To combat this problem effectively, the development of therapeutic agents with diverse mechanisms of action is crucial. Antimi...

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Antibiotics - ISSN 2079-6382