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Biosensors, Volume 10, Issue 8

2020 August - 22 articles

Cover Story: Superparamagnetic iron oxide nanoflowers were synthesized by a one-pot solvothermal route, and characterized (size, morphology, chemical composition, and magnetic properties) to be used as labels in lateral flow immunoassays. Their structure consists of several superparamagnetic cores embedded in a carbon coating with carboxylic groups adequate for bioconjugation using the carbodiimide chemistry. A magnetic lateral flow immunoassay was developed for extracellular vesicle (a novel source of biomarkers) detection directly in a plasma sample. The method showed a low limit of detection (4 × 106 EVs/µL) and a reproducibility (RSD) of 3% (n = 3). In addition, these nanoparticles are easy to concentrate by means of a magnet. This feature makes them promising candidates to be used in immunoseparation to enhance the limit of detection. View this paper.
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Articles (22)

  • Review
  • Open Access
121 Citations
12,947 Views
18 Pages

Electrochemical Detection of Neurotransmitters

  • Saikat Banerjee,
  • Stephanie McCracken,
  • Md Faruk Hossain and
  • Gymama Slaughter

18 August 2020

Neurotransmitters are important chemical messengers in the nervous system that play a crucial role in physiological and physical health. Abnormal levels of neurotransmitters have been correlated with physical, psychotic, and neurodegenerative disease...

  • Review
  • Open Access
42 Citations
6,624 Views
20 Pages

Application of Chemometrics in Biosensing: A Brief Review

  • Ekaterina Martynko and
  • Dmitry Kirsanov

17 August 2020

The field of biosensing is rapidly developing, and the number of novel sensor architectures and different sensing elements is growing fast. One of the most important features of all biosensors is their very high selectivity stemming from the use of b...

  • Article
  • Open Access
16 Citations
5,649 Views
14 Pages

14 August 2020

Gold nanoparticles (AuNPs) are the most thoroughly studied nanoparticles because of their remarkable optical properties. Color changes in assays that use AuNPs can be easily observed with the naked eye, resulting in sensitive colorimetric methods, us...

  • Article
  • Open Access
2 Citations
4,885 Views
12 Pages

A New Possibility for Fermentation Monitoring by Electrical Driven Sensing of Ultraviolet Light and Glucose

  • Cleber A. Amorim,
  • Kate C. Blanco,
  • Ivani M. Costa,
  • Estácio P. de Araújo,
  • Adryelle do Nascimento Arantes,
  • Jonas Contiero and
  • Adenilson J. Chiquito

12 August 2020

Industrial fermentation generates products through microbial growth associated with the consumption of substrates. The efficiency of industrial production of high commercial value microbial products such as ethanol from glucose (GLU) is dependent on...

  • Article
  • Open Access
15 Citations
6,064 Views
10 Pages

Docking Simulation and Sandwich Assay for Aptamer-Based Botulinum Neurotoxin Type C Detection

  • In-Hwan Oh,
  • Dae-Young Park,
  • Ji-Man Cha,
  • Woo-Ri Shin,
  • Ji Hun Kim,
  • Sun Chang Kim,
  • Byung-Kwan Cho,
  • Ji-Young Ahn and
  • Yang-Hoon Kim

12 August 2020

Aptamers are biomaterials that bind to a target molecule through a unique structure, and have high applicability in the diagnostic and medical fields. To effectively utilize aptamers, it is important to analyze the structure of the aptamer binding to...

  • Article
  • Open Access
13 Citations
7,368 Views
14 Pages

11 August 2020

Alkaline phosphatase (ALP) is one of the main biomarkers that is clinically detected in bone and liver disorders using optical assays. The electrochemical principle is important because point-of-care testing is increasing dramatically and absorbance...

  • Communication
  • Open Access
7 Citations
10,540 Views
11 Pages

Urinalysis Using a Diaper-Based Testing Device

  • Wei-Hsuan Sung,
  • Ching-Yi Liu,
  • Chung-Yao Yang,
  • Cheng-Han Chen,
  • Yu-Ting Tsao,
  • Ching-Fen Shen and
  • Chao-Min Cheng

10 August 2020

Urinary tract infections (UTI), one of the most common bacterial infections, annually affect 150 million people worldwide. Infants and the elderly are likely to have missed or delayed diagnosis of UTI due to difficulty clearly describing their sympto...

  • Article
  • Open Access
3 Citations
3,347 Views
9 Pages

Ternary Fingerprints with Reference Odor for Fluctuation-Enhanced Sensing

  • Xiaoyu Yu,
  • Laszlo B. Kish,
  • Jean-Luc Seguin and
  • Maria D. King

9 August 2020

An improved method for fluctuation-enhanced sensing (FES) is introduced. We enhanced the old binary fingerprinting method, where the fingerprint bit values were ±1, by introducing ternary fingerprint bits utilizing a reference odor. In the ter...

  • Article
  • Open Access
14 Citations
7,307 Views
18 Pages

5 August 2020

The illegal use of explosives by terrorists and other criminals is an increasing issue in public spaces, such as airports, railway stations, highways, sports venues, theaters, and other large buildings. Security in these environments can be achieved...

  • Article
  • Open Access
22 Citations
5,340 Views
12 Pages

Nanoelectrode Arrays Fabricated by Thermal Nanoimprint Lithography for Biosensing Application

  • Alessandra Zanut,
  • Alessandro Cian,
  • Nicola Cefarin,
  • Alessandro Pozzato and
  • Massimo Tormen

5 August 2020

Electrochemical sensors are devices capable of detecting molecules and biomolecules in solutions and determining the concentration through direct electrical measurements. These systems can be miniaturized to a size less than 1 µm through the cr...

  • Article
  • Open Access
23 Citations
5,766 Views
11 Pages

5 August 2020

The frequency shift of a shear-horizontal surface-acoustic-wave (SH-SAW) biosensor in which the concentration of biomolecule is determined by the amount of its adsorption on the sensing film was studied. Simulation results were compared with experime...

  • Article
  • Open Access
38 Citations
9,147 Views
13 Pages

Microfluidic-Based Electrochemical Immunosensing of Ferritin

  • Mayank Garg,
  • Martin Gedsted Christensen,
  • Alexander Iles,
  • Amit L. Sharma,
  • Suman Singh and
  • Nicole Pamme

5 August 2020

Ferritin is a clinically important biomarker which reflects the state of iron in the body and is directly involved with anemia. Current methods available for ferritin estimation are generally not portable or they do not provide a fast response. To co...

  • Review
  • Open Access
71 Citations
12,047 Views
22 Pages

3 August 2020

Biosensors constitute selective, sensitive, and rapid tools for disease diagnosis in tissue engineering applications. Compared to standard enzyme-linked immunosorbent assay (ELISA) analytical technology, biosensors provide a strategy to real-time and...

  • Article
  • Open Access
9 Citations
5,739 Views
14 Pages

Instrumentation-Free Semiquantitative Immunoanalysis Using a Specially Patterned Lateral Flow Assay Device

  • Kyung Won Lee,
  • Ye Chan Yu,
  • Hyeong Jin Chun,
  • Yo Han Jang,
  • Yong Duk Han and
  • Hyun C. Yoon

31 July 2020

In traditional colorimetric lateral flow immunoassay (LFI) using gold nanoparticles (AuNPs) as a probe, additional optical transducers are required to quantify the signal intensity of the test line because it presents as a single red-colored line. In...

  • Article
  • Open Access
33 Citations
6,236 Views
18 Pages

29 July 2020

Glucose concentration is an important parameter in biomedicine since glucose is involved in many metabolic pathways in organisms. Many methods for glucose detection have been developed for use in various applications, particularly in the field of hea...

  • Review
  • Open Access
134 Citations
15,125 Views
30 Pages

26 July 2020

In the field of rehabilitation, the electromyography (EMG) signal plays an important role in interpreting patients’ intentions and physical conditions. Nevertheless, utilizing merely the EMG signal suffers from difficulty in recognizing slight...

  • Review
  • Open Access
87 Citations
11,450 Views
21 Pages

Electronic Nose as a Novel Method for Diagnosing Cancer: A Systematic Review

  • Chiara Baldini,
  • Lucia Billeci,
  • Francesco Sansone,
  • Raffaele Conte,
  • Claudio Domenici and
  • Alessandro Tonacci

25 July 2020

Cancer is fast becoming the most important cause of death worldwide, its mortality being mostly caused by late or wrong diagnosis. Novel strategies have been developed to identify early signs of cancer in a minimally obtrusive way, including the Elec...

  • Article
  • Open Access
43 Citations
6,951 Views
15 Pages

Development of an Electrochemical Immunosensor for Specific Detection of Visceral Leishmaniasis Using Gold-Modified Screen-Printed Carbon Electrodes

  • Beatriz R. Martins,
  • Yanne O. Barbosa,
  • Cristhianne M. R. Andrade,
  • Loren Q. Pereira,
  • Guilherme F. Simão,
  • Carlo J. de Oliveira,
  • Dalmo Correia,
  • Robson T. S. Oliveira,
  • Marcos V. da Silva and
  • Renata P. Alves-Balvedi
  • + 4 authors

23 July 2020

Visceral leishmaniasis is a reemerging neglected tropical disease with limitations for its diagnosis, including low concentration of antibodies in the serum of asymptomatic patients and cross-reactions. In this context, this work proposes an electroc...

  • Article
  • Open Access
4 Citations
4,242 Views
15 Pages

Towards Bacteria Counting in DI Water of Several Microliters or Growing Suspension Using Impedance Biochips

  • Mahdi Kiani,
  • Astrid Tannert,
  • Nan Du,
  • Uwe Hübner,
  • Ilona Skorupa,
  • Danilo Bürger,
  • Xianyue Zhao,
  • Daniel Blaschke,
  • Lars Rebohle and
  • Heidemarie Schmidt
  • + 3 authors

23 July 2020

We counted bacterial cells of E. coli strain K12 in several-microliter DI water or in several-microliter PBS in the low optical density (OD) range (OD = 0.05–1.08) in contact with the surface of Si-based impedance biochips with ring electrodes...

  • Review
  • Open Access
34 Citations
15,774 Views
29 Pages

23 July 2020

Current available methods for the clinical diagnosis of urinary tract infection (UTI) rely on a urine dipstick test or culturing of pathogens. The dipstick test is rapid (available in 1–2 min), but has a low positive predictive value, while culturing...

  • Article
  • Open Access
29 Citations
7,221 Views
17 Pages

Carbon-Coated Superparamagnetic Nanoflowers for Biosensors Based on Lateral Flow Immunoassays

  • Amanda Moyano,
  • Esther Serrano-Pertierra,
  • María Salvador,
  • José Carlos Martínez-García,
  • Yolanda Piñeiro,
  • Susana Yañez-Vilar,
  • Manuel Gónzalez-Gómez,
  • José Rivas,
  • Montserrat Rivas and
  • M. Carmen Blanco-López

22 July 2020

Superparamagnetic iron oxide nanoflowers coated by a black carbon layer (Fe3O4@C) were studied as labels in lateral flow immunoassays. They were synthesized by a one-pot solvothermal route, and they were characterized (size, morphology, chemical comp...

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Biosensors - ISSN 2079-6374