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Biosensors, Volume 10, Issue 9

2020 September - 28 articles

Cover Story: Cytokine IL-6 plays a major role in several inflammatory diseases, from rheumatoid arthritis to cancer, and more recently, in COVID-19 pneumonia. In the aim of producing highly sensitive and selective biosensors, we performed a virtual comparison among different IL-6 receptors, two Fabs, an aptamer, a clinical antibody as well as the natural receptors of this protein. The procedure requires translating the biomolecules (the protein alone and complexed with its receptors) into complex elec-trical networks, then allowing a flow of electrons to cross them, in such a way that the electron flux works like a probe exploring the network topology. The selected receptors were ranked accounting for their topological complementarity with IL-6. Two of the analyzed receptors are endorsed in a would-be electrochemical biosensor. View this pa-per.
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Articles (28)

  • Article
  • Open Access
15 Citations
4,273 Views
11 Pages

22 September 2020

A new fluorescent chemosensor for copper (II) and subsequent anion sensing was designed and fully characterized. The sensor consisted of a 1,8-naphthalimide core, bearing two terminal dipicolylamine (DPA) receptor units for binding metal cations, and...

  • Article
  • Open Access
14 Citations
5,152 Views
10 Pages

20 September 2020

Wearable devices equipped with inertial sensors enable objective gait assessment for persons with multiple sclerosis (MS), with potential use in ambulatory care or home and community-based assessments. However, gait data collected in non-controlled s...

(This article belongs to the Section Biosensors and Healthcare)
  • Review
  • Open Access
126 Citations
14,085 Views
23 Pages

18 September 2020

A recent development in portable biosensors allows rapid, accurate, and on-site detection of biomarkers, which helps to prevent disease spread by the control of sources. Less invasive sample collection is necessary to use portable biosensors in remot...

(This article belongs to the Special Issue Smart, Connected, and Portable Biosensors and Bioelectronics for Advancing Human Healthcare, Disease Diagnosis, and Therapeutics)
  • Article
  • Open Access
12 Citations
4,054 Views
19 Pages

16 September 2020

Microfluidic separators based on Deterministic Lateral Displacement (DLD) constitute a promising technique for the label-free detection and separation of mesoscopic objects of biological interest, ranging from cells to exosomes. Owing to the simultan...

(This article belongs to the Collection Recent Developments in Microfluidics)
  • Article
  • Open Access
17 Citations
5,066 Views
13 Pages

Robust Single-Trial EEG-Based Authentication Achieved with a 2-Stage Classifier

  • Uladzislau Barayeu,
  • Nastassya Horlava,
  • Arno Libert and
  • Marc Van Hulle

13 September 2020

The risk of personal data exposure through unauthorized access has never been as imminent as today. To counter this, biometric authentication has been proposed: the use of distinctive physiological and behavioral characteristics as a form of identifi...

(This article belongs to the Section Intelligent Biosensors and Bio-Signal Processing)
  • Article
  • Open Access
44 Citations
6,771 Views
17 Pages

Screen-Printed Glucose Sensors Modified with Cellulose Nanocrystals (CNCs) for Cell Culture Monitoring

  • Ye Tang,
  • Konstantinos Petropoulos,
  • Felix Kurth,
  • Hui Gao,
  • Davide Migliorelli,
  • Olivier Guenat and
  • Silvia Generelli

13 September 2020

Glucose sensors are potentially useful tools for monitoring the glucose concentration in cell culture medium. Here, we present a new, low-cost, and reproducible sensor based on a cellulose-based material, 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)...

(This article belongs to the Section Biosensor Materials)
  • Article
  • Open Access
18 Citations
5,557 Views
12 Pages

11 September 2020

Adenine is an important molecule for biomedical and agricultural research and applications. The detection of low concentration adenine molecules is thus desirable. Surface-enhanced Raman scattering (SERS) is a promising label-free detection and finge...

(This article belongs to the Section Biosensor and Bioelectronic Devices)
  • Article
  • Open Access
27 Citations
6,449 Views
8 Pages

Screen-Printed Sensor for Low-Cost Chloride Analysis in Sweat for Rapid Diagnosis and Monitoring of Cystic Fibrosis

  • Alicia Hauke,
  • Susanne Oertel,
  • Leona Knoke,
  • Vanessa Fein,
  • Christoph Maier,
  • Folke Brinkmann and
  • Michael P. M. Jank

11 September 2020

Analysis of sweat chloride levels in cystic fibrosis (CF) patients is essential not only for diagnosis but also for the monitoring of therapeutic responses to new drugs, such as cystic fibrosis transmembrane conductance regulator (CFTR) modulators an...

(This article belongs to the Special Issue Dedication to Professor Agustín Costa-García: Screen-Printed Electrodes-Based (Bio)sensors: Development and New Challenges of the 21st Century)
  • Article
  • Open Access
11 Citations
5,459 Views
12 Pages

LipiSensors: Exploiting Lipid Nanoemulsions to Fabricate Ionophore-Based Nanosensors

  • Alexandra L. Dailey,
  • Meredith D. Greer,
  • Tyler Z. Sodia,
  • Megan P. Jewell,
  • Tabitha A. Kalin and
  • Kevin J. Cash

10 September 2020

Ionophore-based nanosensors (IBNS) are tools that enable quantification of analytes in complex chemical and biological systems. IBNS methodology is adopted from that of bulk optodes where an ion exchange event is converted to a change in optical outp...

(This article belongs to the Special Issue Fluorescence Biosensors 2020)
  • Review
  • Open Access
26 Citations
6,222 Views
47 Pages

Biomolecules and Electrochemical Tools in Chronic Non-Communicable Disease Surveillance: A Systematic Review

  • Ana Lúcia Morais,
  • Patrícia Rijo,
  • María Belén Batanero Hernán and
  • Marisa Nicolai

10 September 2020

Over recent three decades, the electrochemical techniques have become widely used in biological identification and detection, because it presents optimum features for efficient and sensitive molecular detection of organic compounds, being able to tra...

(This article belongs to the Special Issue Advanced Biosensing Technologies in Medical Applications)
  • Review
  • Open Access
67 Citations
13,273 Views
39 Pages

Electrochemiluminescence Biosensors Using Screen-Printed Electrodes

  • Emiliano Martínez-Periñán,
  • Cristina Gutiérrez-Sánchez,
  • Tania García-Mendiola and
  • Encarnación Lorenzo

9 September 2020

Electrogenerated chemiluminescence (also called electrochemiluminescence (ECL)) has become a great focus of attention in different fields of analysis, mainly as a consequence of the potential remarkably high sensitivity and wide dynamic range. In the...

(This article belongs to the Special Issue Dedication to Professor Agustín Costa-García: Screen-Printed Electrodes-Based (Bio)sensors: Development and New Challenges of the 21st Century)
  • Article
  • Open Access
2 Citations
3,475 Views
11 Pages

9 September 2020

The use of insoluble bismuth salts, typically BiPO4, is known to be a viable alternative to classical Bi3+ ion electrochemical reduction for the preparation of bismuth film electrodes (BiFE) on screen-printed electrodes. The freshly prepared electrod...

(This article belongs to the Special Issue Dedication to Professor Agustín Costa-García: Screen-Printed Electrodes-Based (Bio)sensors: Development and New Challenges of the 21st Century)
  • Article
  • Open Access
5 Citations
3,552 Views
12 Pages

Transient Effect at the Onset of Human Running

  • Christian Weich,
  • Manfred M. Vieten and
  • Randall L. Jensen

8 September 2020

While training and competing as a runner, athletes often sense an unsteady feeling during the first meters on the road. This sensation, termed as transient effect, disappears after a short period as the runners approach their individual running rhyth...

(This article belongs to the Section Biosensors and Healthcare)
  • Article
  • Open Access
7 Citations
4,415 Views
11 Pages

7 September 2020

A carbon nanofiber enriched 8-channel screen-printed electrochemical array was used for the impedimetric detection of SNP related to Factor V Leiden (FV Leiden) mutation, which is the most common inherited form of thrombophilia. FV Leiden mutation se...

(This article belongs to the Special Issue Dedication to Professor Agustín Costa-García: Screen-Printed Electrodes-Based (Bio)sensors: Development and New Challenges of the 21st Century)
  • Review
  • Open Access
32 Citations
9,533 Views
27 Pages

Printed Electrodes in Microfluidic Arrays for Cancer Biomarker Protein Detection

  • Lasangi Dhanapala,
  • Colleen E. Krause,
  • Abby L. Jones and
  • James F. Rusling

7 September 2020

Medical diagnostics is trending towards a more personalized future approach in which multiple tests can be digitized into patient records. In cancer diagnostics, patients can be tested for individual protein and genomic biomarkers that detect cancers...

(This article belongs to the Special Issue Dedication to Professor Agustín Costa-García: Screen-Printed Electrodes-Based (Bio)sensors: Development and New Challenges of the 21st Century)
  • Article
  • Open Access
23 Citations
6,573 Views
8 Pages

A Self-Powered Biosensor for the Detection of Glutathione

  • Brandon G. Roy,
  • Julia L. Rutherford,
  • Anna E. Weaver,
  • Kevin Beaver and
  • Michelle Rasmussen

3 September 2020

Glutathione is an important biological molecule which can be an indicator of numerous diseases. A method for self-powered detection of glutathione levels in solution has been developed using an enzymatic biofuel cell. The device consists of a glucose...

(This article belongs to the Section Biosensor and Bioelectronic Devices)
  • Review
  • Open Access
23 Citations
5,888 Views
19 Pages

Biosensors for Antioxidants Detection: Trends and Perspectives

  • Melinda David,
  • Monica Florescu and
  • Camelia Bala

1 September 2020

Herein we review the recent advances in biosensors for antioxidants detection underlying principles particularly emphasizing advantages along with limitations regarding the ability to discriminate between the specific antioxidant or total content. Re...

(This article belongs to the Special Issue Biosensors: 10th Anniversary Feature Papers)
  • Article
  • Open Access
16 Citations
6,635 Views
10 Pages

1 September 2020

A colorimetric assay was developed for the detection of biothiols, based on the peroxidase-like activity of iodine-capped gold nanoparticles (AuNPs). These AuNPs show a synergetic effect in the form of peroxidase-mimicking activity at the interface o...

(This article belongs to the Section Biosensor and Bioelectronic Devices)
  • Review
  • Open Access
141 Citations
13,575 Views
35 Pages

28 August 2020

Organs-on-chip (OoC), often referred to as microphysiological systems (MPS), are advanced in vitro tools able to replicate essential functions of human organs. Owing to their unprecedented ability to recapitulate key features of the native cellular e...

(This article belongs to the Section Biosensor and Bioelectronic Devices)
  • Article
  • Open Access
58 Citations
7,029 Views
10 Pages

28 August 2020

Lactic acid plays an important role as a biochemical indicator for sports medicine and clinical diagnosis. The detection of lactic acid in sweat is a promising technique without any intrusive inconvenience or risk of infection. In this study, we pres...

(This article belongs to the Section Biosensor and Bioelectronic Devices)
  • Article
  • Open Access
79 Citations
7,895 Views
18 Pages

27 August 2020

Gait phase recognition is of great importance in the development of assistance-as-needed robotic devices, such as exoskeletons. In order for a powered exoskeleton with phase-based control to determine and provide proper assistance to the wearer durin...

(This article belongs to the Section Biosensors and Healthcare)
  • Review
  • Open Access
24 Citations
7,683 Views
21 Pages

26 August 2020

Stroke is a widespread condition that causes 7 million deaths globally. Survivors suffer from a range of disabilities that affect their everyday life. It is a complex condition and there is a need to monitor the different signals that are associated...

(This article belongs to the Section Biosensors and Healthcare)
  • Review
  • Open Access
82 Citations
9,578 Views
19 Pages

Aptasensors for Point-of-Care Detection of Small Molecules

  • Marc Prante,
  • Ester Segal,
  • Thomas Scheper,
  • Janina Bahnemann and
  • Johanna Walter

26 August 2020

Aptamers, a group of nucleic acids which can specifically bind to a target molecule, have drawn extensive interest over the past few decades. For analytics, aptamers represent a viable alternative to gold-standard antibodies due to their oligonucleic...

(This article belongs to the Section Biosensors and Healthcare)
  • Feature Paper
  • Review
  • Open Access
57 Citations
10,689 Views
57 Pages

24 August 2020

Phenolic compounds are secondary metabolites frequently found in plants that exhibit many different effects on human health. Because of the relevant bioactivity, their identification and quantification in agro-food matrices as well as in biological s...

(This article belongs to the Section Biosensor and Bioelectronic Devices)
  • Article
  • Open Access
9 Citations
5,695 Views
19 Pages

Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors

  • Eleonora Alfinito,
  • Matteo Beccaria and
  • Mariangela Ciccarese

24 August 2020

Cytokines are a family of proteins which play a major role in the regulation of the immune system and the development of several diseases, from rheumatoid arthritis to cancer and, more recently, COVID-19. Therefore, many efforts are currently being d...

(This article belongs to the Section Biosensor and Bioelectronic Devices)
  • Article
  • Open Access
29 Citations
5,349 Views
15 Pages

23 August 2020

Organic semiconductors and conducting polymers are the most promising next-generation conducting materials for electrochemical biosensors as the greener and cheaper alternative for electrodes based on transition metals or their oxides. Therefore, pol...

(This article belongs to the Section Biosensor Materials)
  • Article
  • Open Access
8 Citations
4,442 Views
20 Pages

A French–Greek Cross-Site Comparison Study of the Use of Automatic Video Analyses for the Assessment of Autonomy in Dementia Patients

  • Anastasios Karakostas,
  • Alexandra König,
  • Carlos Fernando Crispim-Junior,
  • François Bremond,
  • Alexandre Derreumaux,
  • Ioulietta Lazarou,
  • Ioannis Kompatsiaris,
  • Magda Tsolaki and
  • Philippe Robert

21 August 2020

Background: At present, the assessment of autonomy in daily living activities, one of the key symptoms in Alzheimer’s disease (AD), involves clinical rating scales. Methods: In total, 109 participants were included. In particular, 11 participan...

(This article belongs to the Section Biosensors and Healthcare)
  • Article
  • Open Access
32 Citations
7,392 Views
12 Pages

Rapid Detection of Legionella pneumophila in Drinking Water, Based on Filter Immunoassay and Chronoamperometric Measurement

  • Josune J. Ezenarro,
  • Noemí Párraga-Niño,
  • Miquel Sabrià,
  • Fancisco Javier Del Campo,
  • Francesc-Xavier Muñoz-Pascual,
  • Jordi Mas and
  • Naroa Uria

20 August 2020

Legionella is a pathogenic bacterium, ubiquitous in freshwater environments and able to colonise man-made water systems from which it can be transmitted to humans during outbreaks. The prevention of such outbreaks requires a fast, low cost, automated...

(This article belongs to the Section Biosensor and Bioelectronic Devices)
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Biosensors - ISSN 2079-6374