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Biosensors, Volume 10, Issue 9

2020 September - 28 articles

Cover Story: Cytokine IL-6 plays a major role in several inflammatory diseases, from rheumatoid arthritis to cancer, and more recently, in COVID-19 pneumonia. In the aim of producing highly sensitive and selective biosensors, we performed a virtual comparison among different IL-6 receptors, two Fabs, an aptamer, a clinical antibody as well as the natural receptors of this protein. The procedure requires translating the biomolecules (the protein alone and complexed with its receptors) into complex elec-trical networks, then allowing a flow of electrons to cross them, in such a way that the electron flux works like a probe exploring the network topology. The selected receptors were ranked accounting for their topological complementarity with IL-6. Two of the analyzed receptors are endorsed in a would-be electrochemical biosensor. View this pa-per.
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Articles (28)

  • Article
  • Open Access
15 Citations
4,010 Views
11 Pages

22 September 2020

A new fluorescent chemosensor for copper (II) and subsequent anion sensing was designed and fully characterized. The sensor consisted of a 1,8-naphthalimide core, bearing two terminal dipicolylamine (DPA) receptor units for binding metal cations, and...

  • Article
  • Open Access
14 Citations
4,857 Views
10 Pages

20 September 2020

Wearable devices equipped with inertial sensors enable objective gait assessment for persons with multiple sclerosis (MS), with potential use in ambulatory care or home and community-based assessments. However, gait data collected in non-controlled s...

  • Review
  • Open Access
116 Citations
12,661 Views
23 Pages

18 September 2020

A recent development in portable biosensors allows rapid, accurate, and on-site detection of biomarkers, which helps to prevent disease spread by the control of sources. Less invasive sample collection is necessary to use portable biosensors in remot...

  • Article
  • Open Access
12 Citations
3,688 Views
19 Pages

16 September 2020

Microfluidic separators based on Deterministic Lateral Displacement (DLD) constitute a promising technique for the label-free detection and separation of mesoscopic objects of biological interest, ranging from cells to exosomes. Owing to the simultan...

  • Article
  • Open Access
16 Citations
4,719 Views
13 Pages

Robust Single-Trial EEG-Based Authentication Achieved with a 2-Stage Classifier

  • Uladzislau Barayeu,
  • Nastassya Horlava,
  • Arno Libert and
  • Marc Van Hulle

13 September 2020

The risk of personal data exposure through unauthorized access has never been as imminent as today. To counter this, biometric authentication has been proposed: the use of distinctive physiological and behavioral characteristics as a form of identifi...

  • Article
  • Open Access
38 Citations
6,259 Views
17 Pages

Screen-Printed Glucose Sensors Modified with Cellulose Nanocrystals (CNCs) for Cell Culture Monitoring

  • Ye Tang,
  • Konstantinos Petropoulos,
  • Felix Kurth,
  • Hui Gao,
  • Davide Migliorelli,
  • Olivier Guenat and
  • Silvia Generelli

13 September 2020

Glucose sensors are potentially useful tools for monitoring the glucose concentration in cell culture medium. Here, we present a new, low-cost, and reproducible sensor based on a cellulose-based material, 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)...

  • Article
  • Open Access
18 Citations
5,167 Views
12 Pages

11 September 2020

Adenine is an important molecule for biomedical and agricultural research and applications. The detection of low concentration adenine molecules is thus desirable. Surface-enhanced Raman scattering (SERS) is a promising label-free detection and finge...

  • Article
  • Open Access
24 Citations
6,038 Views
8 Pages

Screen-Printed Sensor for Low-Cost Chloride Analysis in Sweat for Rapid Diagnosis and Monitoring of Cystic Fibrosis

  • Alicia Hauke,
  • Susanne Oertel,
  • Leona Knoke,
  • Vanessa Fein,
  • Christoph Maier,
  • Folke Brinkmann and
  • Michael P. M. Jank

11 September 2020

Analysis of sweat chloride levels in cystic fibrosis (CF) patients is essential not only for diagnosis but also for the monitoring of therapeutic responses to new drugs, such as cystic fibrosis transmembrane conductance regulator (CFTR) modulators an...

  • Review
  • Open Access
23 Citations
5,718 Views
47 Pages

Biomolecules and Electrochemical Tools in Chronic Non-Communicable Disease Surveillance: A Systematic Review

  • Ana Lúcia Morais,
  • Patrícia Rijo,
  • María Belén Batanero Hernán and
  • Marisa Nicolai

10 September 2020

Over recent three decades, the electrochemical techniques have become widely used in biological identification and detection, because it presents optimum features for efficient and sensitive molecular detection of organic compounds, being able to tra...

  • Article
  • Open Access
9 Citations
5,121 Views
12 Pages

LipiSensors: Exploiting Lipid Nanoemulsions to Fabricate Ionophore-Based Nanosensors

  • Alexandra L. Dailey,
  • Meredith D. Greer,
  • Tyler Z. Sodia,
  • Megan P. Jewell,
  • Tabitha A. Kalin and
  • Kevin J. Cash

10 September 2020

Ionophore-based nanosensors (IBNS) are tools that enable quantification of analytes in complex chemical and biological systems. IBNS methodology is adopted from that of bulk optodes where an ion exchange event is converted to a change in optical outp...

  • Review
  • Open Access
58 Citations
12,328 Views
39 Pages

Electrochemiluminescence Biosensors Using Screen-Printed Electrodes

  • Emiliano Martínez-Periñán,
  • Cristina Gutiérrez-Sánchez,
  • Tania García-Mendiola and
  • Encarnación Lorenzo

9 September 2020

Electrogenerated chemiluminescence (also called electrochemiluminescence (ECL)) has become a great focus of attention in different fields of analysis, mainly as a consequence of the potential remarkably high sensitivity and wide dynamic range. In the...

  • Article
  • Open Access
2 Citations
3,244 Views
11 Pages

9 September 2020

The use of insoluble bismuth salts, typically BiPO4, is known to be a viable alternative to classical Bi3+ ion electrochemical reduction for the preparation of bismuth film electrodes (BiFE) on screen-printed electrodes. The freshly prepared electrod...

  • Article
  • Open Access
5 Citations
3,263 Views
12 Pages

Transient Effect at the Onset of Human Running

  • Christian Weich,
  • Manfred M. Vieten and
  • Randall L. Jensen

8 September 2020

While training and competing as a runner, athletes often sense an unsteady feeling during the first meters on the road. This sensation, termed as transient effect, disappears after a short period as the runners approach their individual running rhyth...

  • Article
  • Open Access
7 Citations
4,048 Views
11 Pages

7 September 2020

A carbon nanofiber enriched 8-channel screen-printed electrochemical array was used for the impedimetric detection of SNP related to Factor V Leiden (FV Leiden) mutation, which is the most common inherited form of thrombophilia. FV Leiden mutation se...

  • Review
  • Open Access
31 Citations
8,722 Views
27 Pages

Printed Electrodes in Microfluidic Arrays for Cancer Biomarker Protein Detection

  • Lasangi Dhanapala,
  • Colleen E. Krause,
  • Abby L. Jones and
  • James F. Rusling

7 September 2020

Medical diagnostics is trending towards a more personalized future approach in which multiple tests can be digitized into patient records. In cancer diagnostics, patients can be tested for individual protein and genomic biomarkers that detect cancers...

  • Article
  • Open Access
22 Citations
6,245 Views
8 Pages

A Self-Powered Biosensor for the Detection of Glutathione

  • Brandon G. Roy,
  • Julia L. Rutherford,
  • Anna E. Weaver,
  • Kevin Beaver and
  • Michelle Rasmussen

3 September 2020

Glutathione is an important biological molecule which can be an indicator of numerous diseases. A method for self-powered detection of glutathione levels in solution has been developed using an enzymatic biofuel cell. The device consists of a glucose...

  • Review
  • Open Access
22 Citations
5,382 Views
19 Pages

Biosensors for Antioxidants Detection: Trends and Perspectives

  • Melinda David,
  • Monica Florescu and
  • Camelia Bala

1 September 2020

Herein we review the recent advances in biosensors for antioxidants detection underlying principles particularly emphasizing advantages along with limitations regarding the ability to discriminate between the specific antioxidant or total content. Re...

  • Article
  • Open Access
16 Citations
6,214 Views
10 Pages

1 September 2020

A colorimetric assay was developed for the detection of biothiols, based on the peroxidase-like activity of iodine-capped gold nanoparticles (AuNPs). These AuNPs show a synergetic effect in the form of peroxidase-mimicking activity at the interface o...

  • Review
  • Open Access
119 Citations
12,468 Views
35 Pages

28 August 2020

Organs-on-chip (OoC), often referred to as microphysiological systems (MPS), are advanced in vitro tools able to replicate essential functions of human organs. Owing to their unprecedented ability to recapitulate key features of the native cellular e...

  • Article
  • Open Access
50 Citations
6,243 Views
10 Pages

28 August 2020

Lactic acid plays an important role as a biochemical indicator for sports medicine and clinical diagnosis. The detection of lactic acid in sweat is a promising technique without any intrusive inconvenience or risk of infection. In this study, we pres...

  • Article
  • Open Access
69 Citations
7,355 Views
18 Pages

27 August 2020

Gait phase recognition is of great importance in the development of assistance-as-needed robotic devices, such as exoskeletons. In order for a powered exoskeleton with phase-based control to determine and provide proper assistance to the wearer durin...

  • Review
  • Open Access
19 Citations
7,092 Views
21 Pages

26 August 2020

Stroke is a widespread condition that causes 7 million deaths globally. Survivors suffer from a range of disabilities that affect their everyday life. It is a complex condition and there is a need to monitor the different signals that are associated...

  • Review
  • Open Access
73 Citations
9,014 Views
19 Pages

Aptasensors for Point-of-Care Detection of Small Molecules

  • Marc Prante,
  • Ester Segal,
  • Thomas Scheper,
  • Janina Bahnemann and
  • Johanna Walter

26 August 2020

Aptamers, a group of nucleic acids which can specifically bind to a target molecule, have drawn extensive interest over the past few decades. For analytics, aptamers represent a viable alternative to gold-standard antibodies due to their oligonucleic...

  • Feature Paper
  • Review
  • Open Access
48 Citations
9,654 Views
57 Pages

24 August 2020

Phenolic compounds are secondary metabolites frequently found in plants that exhibit many different effects on human health. Because of the relevant bioactivity, their identification and quantification in agro-food matrices as well as in biological s...

  • Article
  • Open Access
8 Citations
5,292 Views
19 Pages

Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors

  • Eleonora Alfinito,
  • Matteo Beccaria and
  • Mariangela Ciccarese

24 August 2020

Cytokines are a family of proteins which play a major role in the regulation of the immune system and the development of several diseases, from rheumatoid arthritis to cancer and, more recently, COVID-19. Therefore, many efforts are currently being d...

  • Article
  • Open Access
28 Citations
5,069 Views
15 Pages

23 August 2020

Organic semiconductors and conducting polymers are the most promising next-generation conducting materials for electrochemical biosensors as the greener and cheaper alternative for electrodes based on transition metals or their oxides. Therefore, pol...

  • Article
  • Open Access
8 Citations
4,076 Views
20 Pages

A French–Greek Cross-Site Comparison Study of the Use of Automatic Video Analyses for the Assessment of Autonomy in Dementia Patients

  • Anastasios Karakostas,
  • Alexandra König,
  • Carlos Fernando Crispim-Junior,
  • François Bremond,
  • Alexandre Derreumaux,
  • Ioulietta Lazarou,
  • Ioannis Kompatsiaris,
  • Magda Tsolaki and
  • Philippe Robert

21 August 2020

Background: At present, the assessment of autonomy in daily living activities, one of the key symptoms in Alzheimer’s disease (AD), involves clinical rating scales. Methods: In total, 109 participants were included. In particular, 11 participan...

  • Article
  • Open Access
27 Citations
6,957 Views
12 Pages

Rapid Detection of Legionella pneumophila in Drinking Water, Based on Filter Immunoassay and Chronoamperometric Measurement

  • Josune J. Ezenarro,
  • Noemí Párraga-Niño,
  • Miquel Sabrià,
  • Fancisco Javier Del Campo,
  • Francesc-Xavier Muñoz-Pascual,
  • Jordi Mas and
  • Naroa Uria

20 August 2020

Legionella is a pathogenic bacterium, ubiquitous in freshwater environments and able to colonise man-made water systems from which it can be transmitted to humans during outbreaks. The prevention of such outbreaks requires a fast, low cost, automated...

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Biosensors - ISSN 2079-6374