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Review

The Current Trends of Biosensors in Tissue Engineering

by 1,* and 2,*
1
Department of Chemical Engineering, Feng Chia University, Taichung 40724, Taiwan
2
Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 300044, Taiwan
*
Authors to whom correspondence should be addressed.
Biosensors 2020, 10(8), 88; https://doi.org/10.3390/bios10080088
Received: 30 June 2020 / Revised: 25 July 2020 / Accepted: 27 July 2020 / Published: 3 August 2020
(This article belongs to the Special Issue Organ-on-a-Chip for Biosensing)
Biosensors constitute selective, sensitive, and rapid tools for disease diagnosis in tissue engineering applications. Compared to standard enzyme-linked immunosorbent assay (ELISA) analytical technology, biosensors provide a strategy to real-time and on-site monitor micro biophysiological signals via a combination of biological, chemical, and physical technologies. This review summarizes the recent and significant advances made in various biosensor technologies for different applications of biological and biomedical interest, especially on tissue engineering applications. Different fabrication techniques utilized for tissue engineering purposes, such as computer numeric control (CNC), photolithographic, casting, and 3D printing technologies are also discussed. Key developments in the cell/tissue-based biosensors, biomolecular sensing strategies, and the expansion of several biochip approaches such as organs-on-chips, paper based-biochips, and flexible biosensors are available. Cell polarity and cell behaviors such as proliferation, differentiation, stimulation response, and metabolism detection are included. Biosensors for diagnosing tissue disease modes such as brain, heart, lung, and liver systems and for bioimaging are discussed. Finally, we discuss the challenges faced by current biosensing techniques and highlight future prospects of biosensors for tissue engineering applications. View Full-Text
Keywords: biosensors; tissue engineering; organs-on-chips; label-free biosensors; cell-based biosensors; tissue/organ-based biosensors biosensors; tissue engineering; organs-on-chips; label-free biosensors; cell-based biosensors; tissue/organ-based biosensors
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MDPI and ACS Style

Li, Y.-C.E.; Lee, I.-C. The Current Trends of Biosensors in Tissue Engineering. Biosensors 2020, 10, 88. https://doi.org/10.3390/bios10080088

AMA Style

Li Y-CE, Lee I-C. The Current Trends of Biosensors in Tissue Engineering. Biosensors. 2020; 10(8):88. https://doi.org/10.3390/bios10080088

Chicago/Turabian Style

Li, Yi-Chen E., and I-Chi Lee. 2020. "The Current Trends of Biosensors in Tissue Engineering" Biosensors 10, no. 8: 88. https://doi.org/10.3390/bios10080088

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