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Journal of Functional Biomaterials, Volume 16, Issue 3

March 2025 - 42 articles

Cover Story: 3D hydrogel constructs are widely used in drug delivery, cell therapy, tissue engineering, and regenerative medicine. They mimic the native ECM, offering controlled microenvironments and shielding cells from shear stress and immune responses. In this research, electrospun PCL–gelatin composite nanofibers were fabricated and converted into nanofibrils using a cryogrinding method. These nanofibrils were then dispersed in an alginate solution. Next, electrostatic encapsulation was used to form microcapsules with embedded nanofibrils in a gelling bath. We conclude that embedding nanofibrils in alginate hydrogel microcapsules enhances their physicochemical properties and demonstrates strong biological potential for promoting cell growth, proliferation, and differentiation. View this paper
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Articles (42)

  • Article
  • Open Access
1,610 Views
22 Pages

Effect of Pixel Offset Adjustments for XY Plane Dimensional Compensation in Digital Light Processing 3D Printing on the Surface Trueness and Fit of Zirconia Crowns

  • KeunBaDa Son,
  • Ji-Min Lee,
  • Kyoung-Jun Jang,
  • Sang-Kyu Lee,
  • Jun Ho Hwang,
  • Jong Hoon Lee,
  • Hyun Deok Kim,
  • So-Yeun Kim and
  • Kyu-Bok Lee

This study aimed to evaluate the effect of pixel offset adjustments in digital light processing (DLP) three-dimensional (3D) printing on the marginal and internal fit and surface trueness of zirconia crowns. Zirconia crowns were designed using dental...

  • Communication
  • Open Access
1 Citations
3,186 Views
10 Pages

Preclinical Performance of a Novel Dental Implant Design Reducing Mechanical Stress in Cortical Bone

  • Carolin Erbel,
  • Matthias W. Laschke,
  • Tanja Grobecker-Karl and
  • Matthias Karl

This animal study compared the healing performance of a novel implant design characterized by a shift in thread geometry and core diameter with two different surfaces with that of an apically tapered implant. Test Bioactive (n = 9), Test Porous (n =...

  • Article
  • Open Access
1,275 Views
15 Pages

Although dental resin composite restoratives offer a widely used direct-placement treatment option aimed at replacing the form and function of a natural tooth, there are several clinically relevant performance aspects of these materials that can be i...

  • Article
  • Open Access
1 Citations
2,517 Views
22 Pages

Porous Hydrogels Prepared by Two-Step Gelation Method for Bone Regeneration

  • Yongzhi Li,
  • Jiangshan Liu,
  • Jiawei Wei,
  • Li Yuan,
  • Jiaxin Hu,
  • Siluo Dai,
  • Yubao Li and
  • Jidong Li

Hierarchical porous hydrogels possess advantageous characteristics that facilitate cell adhesion, promote tissue growth, and enhance angiogenesis and osteogenesis. In this study, porous composite hydrogels were successfully prepared by a two-step gel...

  • Article
  • Open Access
2,237 Views
14 Pages

Spatial Platform for Periodontal Ligament Angulation and Regeneration: In Vivo Pilot Study

  • Min Guk Kim,
  • Do-Yeon Kim,
  • Hyoung-Gon Ko,
  • Jin-Seok Byun,
  • Joong-Hyun Kim and
  • Chan Ho Park

The periodontal ligament (PDL) is a fibrous connective tissue that anchors the tooth-root surface to the alveolar bone with specific orientations. It plays a crucial role in functional restoration, optimal position stabilities, biomechanical stress t...

  • Article
  • Open Access
2 Citations
1,602 Views
15 Pages

Abnormal expression of miRNAs is associated with the occurrence and progression of cancer and other diseases, making miRNAs essential biomarkers for disease diagnosis and prognosis. However, the intrinsic properties of miRNAs, such as short length, l...

  • Review
  • Open Access
3,732 Views
14 Pages

Optimizing Flexor Digitorum Profundus Tendon Repair: A Narrative Review

  • Rishith R. Mereddy,
  • Emily E. Zona,
  • Camille J. LaLiberte and
  • Aaron M. Dingle

Zone II flexor digitorum profundus (FDP) tendon injuries are complex, and present significant challenges in hand surgery, due to the need to balance strength and flexibility during repair. Traditional suture techniques often lead to complications suc...

  • Article
  • Open Access
9 Citations
2,325 Views
20 Pages

This study assessed the changes in the mechanical and surface properties of the transition zone in multilayered translucent monolithic zirconia subjected to long-term hydrothermal aging. A total of 360 disk-shaped specimens (diameter: 15.0 mm; thickn...

  • Article
  • Open Access
3 Citations
3,198 Views
17 Pages

The aim of this study was to compare the efficacy of the guided tissue regeneration (GTR) of periodontal infrabony defects using the frozen radiation-sterilized allogenic bone graft (FRSABG) versus deproteinized bovine bone mineral (DBBM) 5 years aft...

  • Article
  • Open Access
4 Citations
1,833 Views
13 Pages

Effects of ECM Components on Periodontal Ligament Stem Cell Differentiation Under Conditions of Disruption of Wnt and TGF-β Signaling Pathways

  • Alla V. Kuznetsova,
  • Olga P. Popova,
  • Tamara I. Danilova,
  • Andrey V. Latyshev,
  • Oleg O. Yanushevich and
  • Alexey A. Ivanov

Periodontitis is accompanied by inflammation that causes dysregulation of the Wnt/β-catenin and TGF-β signaling pathways. This leads to a violation of the homeostasis of periodontal tissues. Components of the extracellular matrix (ECM) are...

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J. Funct. Biomater. - ISSN 2079-4983