Functionalized Polymeric Biomaterials: Design and Applications, 2nd Edition

Special Issue Editors


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Guest Editor
Neuro-Computing and Neuro-Robotics Research Group, Complutense University of Madrid, Madrid, Spain
Interests: silk; biomaterials; neural plasticity; neural interfaces
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Guest Editor
Escuela Técnica Superior de Ingenieros de Caminos Canales y Puertos, Madrid, Spain
Interests: silk; biomaterials; functionalization; cell therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The functionalization of biomaterials offers a promising strategy for improving the response of an organism to an implant. This approach is especially convenient when combined with polymeric materials that may be used in applications such as scaffolds for tissue regeneration and repair, vehicles for drugs and/or stem cell encapsulation and delivery (precision and personalized medicine), artificial tendons and ligament development, as structural elements of artificial extracellular matrices, etc. The synthesis of these functionalized biomaterials must consider the employment of biocompatible molecules, such as silk or collagen, that, in addition, should be produced in different formats (e.g., films, fibers, sponges, gels)  by using appropriate processing techniques. Since functionalization requires introduction at the surface of the material of reactive groups, it is possible to consider the different crosslinking chemistries compatible with each material and format. The need to bind the reactive moieties to the material also offers a nice opportunity to employ genetic engineering techniques to enhance the properties exhibited by the natural material. In this context, this Special Issue aims to provide an updated view of the main promises and challenges of using this type of material for biomedical applications.

Prof. Dr. Fivos Panetsos
Prof. Dr. Jose Perez-Rigueiro
Guest Editors

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Keywords

  • silk
  • functionalization
  • tissue engineering
  • regenerative medicine
  • stem cells
  • crosslinker

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Published Papers (1 paper)

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Research

23 pages, 9992 KiB  
Article
Electrospun Polycaprolactone–Gelatin Fibrils Enabled 3D Hydrogel Microcapsules for Biomedical Applications
by Felix Tettey-Engmann, Thakur Sapkota, Sita Shrestha, Narayan Bhattarai and Salil Desai
J. Funct. Biomater. 2025, 16(3), 85; https://doi.org/10.3390/jfb16030085 - 2 Mar 2025
Viewed by 704
Abstract
Microcapsules provide a microenvironment by improving the protection and delivery of cells and drugs to specific tissue areas, promoting cell integration and tissue regeneration. Effective microcapsules must not only be permeable for micronutrient diffusion but mechanically stable. Alginate hydrogel is one of the [...] Read more.
Microcapsules provide a microenvironment by improving the protection and delivery of cells and drugs to specific tissue areas, promoting cell integration and tissue regeneration. Effective microcapsules must not only be permeable for micronutrient diffusion but mechanically stable. Alginate hydrogel is one of the commonly used biomaterials for fabricating microcapsules due to its gel-forming ability and low toxicity. However, its mechanical instability, inertness, and excessive porosity have impeded its use. Embedding nanofibrils in the alginate hydrogel microcapsules improves their biological and mechanical properties. In this research, electrospun composite nanofibers of PCL–gelatin (PG) were first fabricated, characterized, and cryoground. The filtered and cryoground powder solution was mixed with the alginate solution and through electrospray, fabricated into microcapsules. Parameters such as flow rate, voltage, and hydrogel composition, which are critical in the electrostatic encapsulation process, were optimized. The microcapsules were further immersed in different solvent environments (DI water, complete media, and PBS), which were observed and compared for their morphology, size distribution, and mechanical stability properties. The average diameters of the PG nanofibers ranged between 0.2 and 2 μm, with an average porosity between 58 and 73%. The average size of the microcapsules varied between 300 and 900 μm, depending on the solvent environment. Overall, results showed an improved alginate 3D hydrogel network suitable for biomedical applications. Full article
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