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Nanobiomaterial Mechanistic Applications in Drug Delivery and Translational Research
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Nanobiomaterial Mechanistic Applications in Drug Delivery and Translational Research

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Drug Delivery".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 7931

Special Issue Editors

Dr. Suresh K. Verma

E-Mail Website
Guest Editor
1. Department of Physics and Astronomy (Materials Theory), Uppsala University, 75121 Uppsala, Sweden
2. School of Biotechnology, KIIT University, Bhubaneswar 751024, India
Interests: nanobiotechnology; drug delivery; nanomedicine; nanotoxicology; green nanotechnology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Mrutyunjay Suar

E-Mail Website
Guest Editor
School of Biotechnology, KIIT University, Bhubaneswar 751024, India
Interests: nanobiotechnology; nanovaccines; drug delivery; infection biology; nanomedicine

Special Issue Information

Dear Colleagues,

Recent advancements in nanobiotechnology have explored the immense potential of new nano-based biomaterials for different biomedical and environmental applications. The application of different types of inorganic and organic nanomaterials that are synthesized and form different processes (chemical, physical, biological) has spread to many scientific fields such as cancer biology, infection biology, and microbiology.

Researchers are trying to explore the biomedical usage of nanomaterials by investigating their role in drug delivery to solve the riddles of biomedical sciences in different diseases and the inhibition of microbial infections. However, detailed mechanistic investigations regarding nanobiocompatibility and nano–bio interactions are important to understand the nitty gritty of nanomaterial-based medicine fo their translation to further applications.

Moreover, a detailed understanding of the physical, biochemical, and biological properties of newly synthesized nanomaterials is required for the desired fabrication to implicate them for diagnosis and the treatment of different diseases through different modes of drug delivery. These properties can be proved as decisive factors to determine the role of nanomaterials in the cellular and molecular physiology of biological entities.

This Special Issue calls for a range of studies in the field of nanobiotechnology that are poised to carry out mechanistic research on nanomaterial applications in the lab and to analyze clinical aspects through basic and translation explorations in the field of drug delivery. The information will be beneficial for discovering new findings in the field of nanomaterial science for biotechnology applications, especially with regard to drug delivery for healthcare.

We invite manuscripts that entail a wide range of issues and concerns regarding nanomaterial properties, their scale in the lab, and translation applications including, but not limited to:

  • Newly synthesized functional nanobiomaterials for biomedical applications.
  • Mechanistic cellular and molecular investigations of nano–bio interactions for drug delivery applications.
  • Clinical and translational nanobiomaterials for diagnosis and treatment.
  • Infection-resisting nanobiomaterials.

We very much look forward to your valuable contribution.

Dr. Suresh K. Verma
Prof. Dr. Mrutyunjay Suar
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery
  • nano–bio interaction
  • nanomedicine
  • nanobiocompatibility
  • nanobiosensors
  • molecular and cellular analysis

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

15 pages, 81411 KiB  
Article
Long-Term Safety Evaluation of Fluorescent Gold Nanoclusters Conjugated with α-Lipoic Acid: Insights from a Six-Month In Vivo Study
by Yu-Wei Lai, Yi-Nan Lee, Hung-I Yeh, Yih-Jer Wu, Wen-Hsiung Chan, Shih-Wei Wang, Chao-Feng Lin, Chun-Hsuan Lin, Yun-Fang Chen and Ching-Hu Chung
J. Funct. Biomater. 2025, 16(3), 89; https://doi.org/10.3390/jfb16030089 - 5 Mar 2025
Viewed by 578
Abstract
Background: Fluorescent gold nanoclusters conjugated with α-lipoic acid (FANCs) have shown great promise for drug development. In a previous study, FANCs did not show any acute or subacute toxicity under 0.6–20 μM/100 μL/25 g body weight in male and female ICR mice. However, [...] Read more.
Background: Fluorescent gold nanoclusters conjugated with α-lipoic acid (FANCs) have shown great promise for drug development. In a previous study, FANCs did not show any acute or subacute toxicity under 0.6–20 μM/100 μL/25 g body weight in male and female ICR mice. However, the chronic toxicity of FANCs has not been studied. Aim of study: This study used oral administration of FANCs to determine the long-term safety profile and adverse effects in ICR mice. Methods: In vivo chronic toxicity was examined via oral administration of FANCs to male and female ICR mice. The daily food consumption, body weight, hematological profile, serum biochemical profile, organ coefficient, histopathological changes, and survival rate of the mice were calculated. Results: FANCs did not result in mortality due to chronic toxicity in both male and female mice. The animal behavior, body weight, hematological profile, serum biochemical profile, and organ coefficient showed no treatment-related malignant changes. This indicates that FANCs do not cause liver, renal, or other organ damage. Conclusions: These results indicate that the no-observed-adverse-effect level (NOAEL) is 20 μM/100 μL/25 g for 6 months of treatment in male and female ICR mice. Full article
(This article belongs to the Special Issue Nanobiomaterial Mechanistic Applications in Drug Delivery and Translational Research)
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12 pages, 3138 KiB  
Article
Hypochlorous Acid-Activated UCNPs-LMB/VQIVYK Multifunctional Nanosystem for Alzheimer’s Disease Treatment
by Luying Qiao, Yang Shen, Guangzhi Li, Guanglei Lv and Chunxia Li
J. Funct. Biomater. 2023, 14(4), 207; https://doi.org/10.3390/jfb14040207 - 8 Apr 2023
Cited by 2 | Viewed by 1899
Abstract
The development of nanosystems, which can photooxygenate amyloid-β (Aβ), detect the Tau protein, and inhibit effectively the Tau aggregation, is increasingly important in the diagnosis and therapy of Alzheimer’s disease (AD). Herein, UCNPs-LMB/VQIVYK (UCNPs: upconversion nanoparticles, LMB: Leucomethylene blue, and VQIVYK: Biocompatible peptide) [...] Read more.
The development of nanosystems, which can photooxygenate amyloid-β (Aβ), detect the Tau protein, and inhibit effectively the Tau aggregation, is increasingly important in the diagnosis and therapy of Alzheimer’s disease (AD). Herein, UCNPs-LMB/VQIVYK (UCNPs: upconversion nanoparticles, LMB: Leucomethylene blue, and VQIVYK: Biocompatible peptide) is designed as a HOCl-controlled released nanosystem for AD synergistic treatment. Under exposure to high levels of HOCl, the released MB from UCNPs-LMB/VQIVYK will produce singlet oxygen (1O2) under red light to depolymerize Aβ aggregation and reduce cytotoxicity. Meanwhile, UCNPs-LMB/VQIVYK can act as an inhibitor to decrease Tau-induced neurotoxicity. Besides, UCNPs-LMB/VQIVYK can be used for upconversion luminescence (UCL) due to its unexceptionable luminescence properties. This HOCl-responsive nanosystem offers a new therapy for AD treatment. Full article
(This article belongs to the Special Issue Nanobiomaterial Mechanistic Applications in Drug Delivery and Translational Research)
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12 pages, 4545 KiB  
Article
Characterization of Bioactive Compounds Having Antioxidant and Anti-Inflammatory Effects of Liliaceae Family Flower Petal Extracts
by Neha Kaushik, June-Hyun Kim, Linh Nhat Nguyen, Nagendra Kumar Kaushik and Kyung-A Choi
J. Funct. Biomater. 2022, 13(4), 284; https://doi.org/10.3390/jfb13040284 - 8 Dec 2022
Cited by 4 | Viewed by 4532
Abstract
Beneficial natural products utilized in cosmetics formulation and pharmaceutical applications are of enormous interest. Lily (Lilium) serves as an essential edible and medicinal plant species with wide classification. Here, we have performed the screening of various extracts that were prepared from flower petals [...] Read more.
Beneficial natural products utilized in cosmetics formulation and pharmaceutical applications are of enormous interest. Lily (Lilium) serves as an essential edible and medicinal plant species with wide classification. Here, we have performed the screening of various extracts that were prepared from flower petals grown from the bulbs of eight Lilium varieties, with a viewpoint to their applicability as a viable source of natural anti-inflammatory and antioxidants agent. Interestingly, our findings indicated that all ethanol and water extracts exhibited a substantially differential spectrum of antioxidant as well as anti-inflammatory properties. Specifically, Serrano showed a close similarity among ethanol and water extracts among all tested lily petal extracts. Therefore, to obtain a detailed analysis of chemical compounds, liquid chromatography–mass spectroscopy was performed in ethanolic and water extracts of Serrano petals. Together, our preliminary results indicated that lily petals extracts used in this study could serve as a basis to develop a potential new whitening agent with powerful antioxidant and anti-inflammatory properties for medicinal, functional food, and cosmetic applications. Full article
(This article belongs to the Special Issue Nanobiomaterial Mechanistic Applications in Drug Delivery and Translational Research)
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