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Osteoarthritis: Recent Advances in Biomaterials for Diagnosis and Treatment
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Osteoarthritis: Recent Advances in Biomaterials for Diagnosis and Treatment

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Bone Biomaterials".

Deadline for manuscript submissions: closed (20 August 2024) | Viewed by 4154

Special Issue Editors

Dr. Cristiana Gonçalves

E-Mail Website
Guest Editor
1. 3B’s Research Group, I3Bs—Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, Portugal
2. ICVS/3B’s–PT Government Associate Laboratory, Braga, 4805-017 Guimarães, Portugal
Interests: biomaterials; viscosupplementation; hydrogels; osteoarthritis; regenerative medicine; tissue engineering
Prof. Dr. Rui L. Reis

E-Mail Website
Guest Editor
1. 3B’s Research Group, I3Bs—Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, Portugal
2. ICVS/3B’s–PT Government Associate Laboratory, Braga, 4805-017 Guimarães, Portugal
Interests: tissue engineering; regenerative medicine; biomaterials; biomimetics; biodegradable materials; 3D in vitro models; cancer modelling
Special Issues, Collections and Topics in MDPI journals
Dr. Joaquim Miguel Oliveira

E-Mail Website
Guest Editor
1. 3B’s Research Group, I3Bs—Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimarães, Portugal
2. ICVS/3B’s–PT Government Associate Laboratory, Braga, 4805-017 Guimarães, Portugal
Interests: nanobiomaterials; nanomedicine; theranostics; tissue engineering; bio 3D printing; 3D in vitro tissue models of disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to introduce the Special Issue on "Osteoarthritis: Recent Advances in Biomaterials for Diagnosis and Treatment".

Osteoarthritis (OA) is a major health problem with increasing prevalence and incidence. Improving the diagnosis and treatment of OA is crucial to alleviate the burden of this debilitating condition. Recent research in this field has focused on developing new diagnostic tools, including imaging techniques and biomarkers, but significant advancements have also been made in developing novel biomaterials and therapeutic approaches for OA. Significant advances have been made in developing novel biomaterials and therapeutic approaches, such as injectable therapies such as hyaluronic acid, or other polymers with platelet-rich plasma, and regenerative medicine methodologies like stem cell therapy and tissue engineering. These biomaterials have shown promising results in reducing pain and inflammation, improving joint function, and promoting cartilage repair in OA patients. Biologics (monoclonal antibodies and cytokine inhibitors), small molecules (monoclonal antibodies and cytokine inhibitors), and gene therapy (gene editing techniques to modify genes involved in cartilage degeneration and inflammation) also hold promise for the future.

This Special Issue is a valuable resource for healthcare professionals and students interested in advancing their understanding of OA and developing new research methods and biomaterials-based solutions to enhance patient outcomes.

We welcome your contributions and look forward to receiving them.

Dr. Cristiana Gonçalves
Prof. Dr. Rui L. Reis
Dr. Joaquim Miguel Oliveira
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • osteoarthritis
  • gene therapy
  • diagnosis
  • treatment
  • biomaterials
  • regenerative medicine
  • cartilage repair
  • joint replacement
  • tissue engineering
  • stem cells
  • biomechanics
  • precision medicine

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Published Papers (2 papers)

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11 pages, 2074 KiB  
Article
In Vitro Biocompatibility of the Novel Ceramic Composite Baghdadite for Defect Augmentation in Revision Total Hip Arthroplasty
by Max Jaenisch, Christian Guder, Robert Ossendorff, Thomas M. Randau, Sascha Gravius, Dieter C. Wirtz, Andreas C. Strauss and Frank A. Schildberg
J. Funct. Biomater. 2023, 14(10), 517; https://doi.org/10.3390/jfb14100517 - 15 Oct 2023
Cited by 1 | Viewed by 2107
Abstract
Biological augmentation of bony defects in weight-bearing areas of both the acetabulum and the femur remains challenging. The calcium-silicate-based ceramic Baghdadite is a very interesting material to be used in the field of revision total hip arthroplasty for the treatment of bony defects [...] Read more.
Biological augmentation of bony defects in weight-bearing areas of both the acetabulum and the femur remains challenging. The calcium-silicate-based ceramic Baghdadite is a very interesting material to be used in the field of revision total hip arthroplasty for the treatment of bony defects in weight-bearing and non-weight-bearing areas alike. The aim of this study was to investigate the biocompatibility of Baghdadite utilizing an osteoblast-like, human osteosarcoma cell line (MG-63) and the human monocytic leukemia-derived cell line (THP-1). THP-1-derived macrophages and MG-63 were indirectly exposed to Baghdadite for 7 days using a transwell system. Viability was assessed with MTT assay and pH analysis. To investigate proliferation rate, both cell lines were labelled using CFSE and flow cytometrically analyzed. ELISA was used to measure the secretion of IL-1ß, IL-6 and TNFα. The investigation of viability, while showing a slight difference in optical density for the MTT assays in MG-63 cells, did not present a meaningful difference between groups for both cell lines. The comparison of pH and the proportion of living cells between groups did not present with a significant difference for both THP-1 and MG-63. Baghdadite did not have a relevant impact on the proliferation rate of the investigated cell lines. Mean fluorescence intensity was calculated between groups with no significant difference. Baghdadite exerted a proinflammatory effect, which could be seen in an upregulated production of TNFα in macrophages. Production of IL-1ß and IL-6 was not statistically significant, but the IL-6 ELISA showed a trend to an upregulated production as well. A similar effect on MG-63 was not observed. No relevant cytotoxicity of Baghdadite ceramics was encountered. Baghdadite ceramics exhibit a proinflammatory potential by significantly increasing the secretion of TNFα in THP-1-derived macrophages. Whether this proinflammatory potential results in a clinically relevant effect on osteointegration is unclear and requires further investigation. Baghdadite ceramics provide an interesting alternative to conventional bone substitutes and should be further investigated in a biomechanical and in vivo setting. Full article
(This article belongs to the Special Issue Osteoarthritis: Recent Advances in Biomaterials for Diagnosis and Treatment)
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11 pages, 664 KiB  
Systematic Review
Treatment of Knee Osteoarthritis and Chondral Injury with Umbilical Cord/Wharton’s Jelly-Derived Mesenchymal Stem Cells: A Systematic Review of Safety and Efficacy
by Mohd Ishak-Samrin, Isa Naina-Mohamed, Mohamed S. Zulfarina, S. Fadilah Abdul Wahid, Ahmad Farihan Mohd Don, Norlelawati Mohamad, Muhamad Karbela Reza Ramlan and Akmal Hisham Md Yusoff Badrul
J. Funct. Biomater. 2025, 16(3), 84; https://doi.org/10.3390/jfb16030084 - 1 Mar 2025
Viewed by 1061
Abstract
Knee osteoarthritis (KOA) is a major cause of pain and disability worldwide, with no current treatment modality able to prevent the progressive destruction of articular cartilage. Mesenchymal stem cells (MSCs) have attracted interest in treating KOA and cartilage injury due to their self-renewal [...] Read more.
Knee osteoarthritis (KOA) is a major cause of pain and disability worldwide, with no current treatment modality able to prevent the progressive destruction of articular cartilage. Mesenchymal stem cells (MSCs) have attracted interest in treating KOA and cartilage injury due to their self-renewal and multidirectional differentiation potential, as well as local bioactive factors with immunomodulatory and regenerative potential. This study aimed to evaluate the currently available studies using the intra-articular injection of Wharton’s jelly MSCs for KOA and cartilage injury. We analyzed all clinical trials published from inception to 31 December 2023. Six studies met the inclusion criteria, for a total of 97 patients and 134 knees. The follow-up period ranged from 3 to 48 months. There were no serious adverse effects noted. There was significant improvement in functional outcomes in the form of VAS, WOMAC, KOOS, and IKDC parameters, though radiological outcomes demonstrated mixed results. In conclusion, patients with KOA treated with intra-articular injections of Wharton’s jelly MSCs showed improvements in functional outcomes with no severe adverse effects. Multiple injections of Wharton’s jelly MSCs showed better outcomes compared to single-injection techniques. Wharton’s jelly MSCs may have potential as a cornerstone in the future treatment of KOA. Full article
(This article belongs to the Special Issue Osteoarthritis: Recent Advances in Biomaterials for Diagnosis and Treatment)
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