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Journal of Functional Biomaterials, Volume 14, Issue 5

May 2023 - 51 articles

Cover Story: Ion-substituted calcium phosphate (CP) coatings have been extensively studied as promising materials for biomedical implants, due to their ability to enhance biocompatibility, osteoconductivity, and bone formation. This systematic review aims to provide a comprehensive analysis of the current state of the art in ion-doped CP-based coatings for orthopaedic and dental implant applications. Specifically, the effects of ion addition on the physicochemical, mechanical, and biological properties of CP coatings was evaluated, along with the contribution and additional effects (in a separate or a synergistic way) of different components used together with ion-doped CP for advanced composite coatings. In the final part, the effects of antibacterial coatings on specific bacteria strains are reported. View this paper
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Articles (51)

  • Review
  • Open Access
23 Citations
4,875 Views
32 Pages

Recent Advancements in Electrospun Chitin and Chitosan Nanofibers for Bone Tissue Engineering Applications

  • S Shree Ganesh,
  • Ramprasad Anushikaa,
  • Venkadesan Sri Swetha Victoria,
  • Krishnaraj Lavanya,
  • Abinaya Shanmugavadivu and
  • Nagarajan Selvamurugan

Treatment of large segmental bone loss caused by fractures, osteomyelitis, and non-union results in expenses of around USD 300,000 per case. Moreover, the worst-case scenario results in amputation in 10% to 14.5% of cases. Biomaterials, cells, and re...

  • Review
  • Open Access
48 Citations
8,469 Views
18 Pages

Surface Coatings of Dental Implants: A Review

  • Angelo Michele Inchingolo,
  • Giuseppina Malcangi,
  • Laura Ferrante,
  • Gaetano Del Vecchio,
  • Fabio Viapiano,
  • Alessio Danilo Inchingolo,
  • Antonio Mancini,
  • Ciro Annicchiarico,
  • Francesco Inchingolo and
  • Gianna Dipalma
  • + 3 authors

Replacement of missing teeth is possible using biocompatible devices such as endosseous implants. This study aims to analyze and recognize the best characteristics of different implant surfaces that ensure good peri-implant tissue healing and thus cl...

  • Review
  • Open Access
6 Citations
4,055 Views
18 Pages

The Use of Warm Air for Solvent Evaporation in Adhesive Dentistry: A Meta-Analysis of In Vitro Studies

  • Rim Bourgi,
  • Louis Hardan,
  • Carlos Enrique Cuevas-Suárez,
  • Francesco Scavello,
  • Davide Mancino,
  • Naji Kharouf and
  • Youssef Haikel

Any excess solvent from dental adhesive systems must be eliminated prior to material photopolymerization. For this purpose, numerous approaches have been proposed, including the use of a warm air stream. This study aimed to investigate the effect of...

  • Review
  • Open Access
60 Citations
8,058 Views
27 Pages

A Review of the Application of Natural and Synthetic Scaffolds in Bone Regeneration

  • Sok Kuan Wong,
  • Michelle Min Fang Yee,
  • Kok-Yong Chin and
  • Soelaiman Ima-Nirwana

The management of bone defects is complicated by the presence of clinical conditions, such as critical-sized defects created by high-energy trauma, tumour resection, infection, and skeletal abnormalities, whereby the bone regeneration capacity is com...

  • Article
  • Open Access
10 Citations
2,624 Views
16 Pages

Cytotoxicity Induced by Black Phosphorus Nanosheets in Vascular Endothelial Cells via Oxidative Stress and Apoptosis Activation

  • Hao Dong,
  • Yin Wen,
  • Jiating Lin,
  • Xianxian Zhuang,
  • Ruoting Xian,
  • Ping Li and
  • Shaobing Li

Black phosphorus (BP), an emerging two-dimensional material with unique optical, thermoelectric, and mechanical properties, has been proposed as bioactive material for tissue engineering. However, its toxic effects on physiological systems remain obs...

  • Article
  • Open Access
1 Citations
2,102 Views
15 Pages

Addition of Resolvins D1 or E1 to Collagen Membranes Mitigates Their Resorption in Diabetic Rats

  • Michal Almogy,
  • Ofer Moses,
  • Nathan Schiffmann,
  • Evgeny Weinberg,
  • Carlos E. Nemcovsky and
  • Miron Weinreb

Uncontrolled diabetes is characterized by aberrant inflammatory reactions and increased collagenolysis. We have reported that it accelerates the degradation of implanted collagen membranes (CM), thus compromising their function in regenerative proced...

  • Article
  • Open Access
8 Citations
2,205 Views
13 Pages

Photobiomodulation and Inorganic Bovine Bone in Guided Bone Regeneration: Histomorphometric Analysis in Rats

  • Nicole Rosa de Freitas,
  • Luísa Belluco Guerrini,
  • Luis Augusto Esper,
  • Michyele Cristhiane Sbrana,
  • Caroline Chepernate Vieira dos Santos and
  • Ana Lúcia Pompéia Fraga de Almeida

The objective of this study was to evaluate the efficacy of photobiomodulation in the bone regeneration of critical-sized defects (CSD) filled with inorganic bovine bone associated or not with collagen membranes. The study has been conducted on 40 cr...

  • Systematic Review
  • Open Access
11 Citations
2,657 Views
13 Pages

Objective: Socket preservation techniques have been used to maintain the ridge dimension following tooth extraction. The materials used influence the quality and quantity of newly formed bone. Therefore, the aim of this article was to systematically...

  • Article
  • Open Access
6 Citations
3,996 Views
11 Pages

Development of Salmon Sperm DNA/Regenerated Silk Bio-Based Films for Biomedical Studies on Human Keratinocyte HaCaT Cells under Solar Spectrum

  • Maria Rachele Ceccarini,
  • Francesca Ripanti,
  • Veronica Raggi,
  • Alessandro Paciaroni,
  • Caterina Petrillo,
  • Lucia Comez,
  • Kevin Donato,
  • Matteo Bertelli,
  • Tommaso Beccari and
  • Luca Valentini

In this study, we fabricated adhesive patches from silkworm-regenerated silk and DNA to safeguard human skin from the sun’s rays. The patches are realized by exploiting the dissolution of silk fibers (e.g., silk fibroin (SF)) and salmon sperm D...

  • Article
  • Open Access
10 Citations
2,754 Views
13 Pages

An Eco-Friendly Process to Extract Hydroxyapatite from Sheep Bones for Regenerative Medicine: Structural, Morphologic and Electrical Studies

  • Sílvia Rodrigues Gavinho,
  • Mehmet Bozdag,
  • Cevriye Kalkandelen,
  • Joana Soares Regadas,
  • Suresh Kumar Jakka,
  • Oguzhan Gunduz,
  • Faik Nuzhet Oktar and
  • Manuel Pedro Fernandes Graça

Hydroxyapatite (HA) promotes excellent bone regeneration in bone-tissue engineering, due to its similarity to bone mineral and its ability to connect to living tissues. These factors promote the osteointegration process. This process can be enhanced...

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J. Funct. Biomater. - ISSN 2079-4983