J. Clin. Med., Volume 9, Issue 11 (November 2020) – 409 articles
Cover Story (view full-size image): Perturbations in mitochondrial dysfunction play significant role in the pathogenesis of HF. Pathophysiological mechanisms leading to mitochondrial dysfunction in HF are numerous and range from changes in morphology and dynamics; to altered endoplasmic reticulum (ER)-mitochondrial (mt) tethering due to altered signaling and calcium cycling at the ER-mt interphase; enhanced mt-calcium uptake and overload; increased reactive oxygen species and apoptosis; and decreased mt-biogenesis, and oxidative capacity. Investigational drugs targeting specific areas of mt-dysfunction are being investigated. There remain an unmet need to explore molecular mechanisms modulating the multiplicity of mt-dysfunction in HF for better effective therapeutic interventions. View this paper
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