- 3.4Impact Factor
- 9.9CiteScore
- 20 daysTime to First Decision
Vaccines, Volume 9, Issue 7
July 2021 - 122 articles
Cover Story: The aim of the present study was to identify mRNA expression profiles and to assess the impact of gut microbiome composition for predicting viral load control after antiretroviral therapy interruption upon vaccination. Patients with a decrease in their viral load of >0.5 log10 copies/mL by 12 weeks after antiretroviral therapy interruption were considered to be responders. In total, 66 genes were differentially expressed between the responders and non-responders; they were involved in the host defense response to a virus. Regarding the gut microbiota, we found important differences at the genus level, and it was associated with the metabolic production of short-chain fatty acids. The evidence now consistently shows that short-chain fatty acid depletion occurs in HIV-infected individuals receiving antiretroviral treatment. View this paper
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Vaccines - ISSN 2076-393X