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Vaccines, Volume 8, Issue 4

December 2020 - 228 articles

Cover Story: A human or nonhuman adenoviral (Ad) vector-based vaccine platform is a versatile egg-independent and cost-effective approach for generating large numbers of influenza vaccine doses in a short timeframe. The activation of innate immunity by the Ad vector induces broad, durable, and protective influenza-specific humoral and cell-mediated immune responses. Due to the availability of less-prevalent human Ad vectors and nonhuman Ad vectors as vaccine platforms, there will be a minimal impact of preexisting Ad vector immunity on vaccine efficacy. An Ad vector-based vaccine platform is well suited for designing effective vaccines not only for seasonal and pandemic influenza but also for other infectious diseases. View this paper.
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Vaccines - ISSN 2076-393XCreative Common CC BY license