Vaccines, Volume 7, Issue 2
2019 June - 23 articles
Cover Story: A novel rod-shaped nanoparticle, made of the coat protein of papaya mosaic virus (PapMV) self-assembled around an ssRNA, was used as a vaccine platform. The PapMV nanoparticle is a strong inducer of the toll like receptor 7/8. Consequently, the attachment of an antigen to the nanoparticle enhances its immunogenicity. Using a bacterial transpeptidase (sortase A), two different full-length viral protein antigens (FLVPAs), the simian immunodeficiency virus (SIV) GAG and the influenza A nucleoprotein (NP), were covalently attached to each extremity of PapMV nanoparticles. The resulting coupled nanoparticles showed a significant increase of the cellular and humoral immune responses to the FLVPAs. This approach allows rapidly developing a vaccine formulation with large viral protein antigens that contain several protective B and T cell epitopes. View this paper
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Vaccines - ISSN 2076-393X