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Vaccines, Volume 7, Issue 1
March 2019 - 33 articles
Cover Story: African swine fever virus (ASFV) causes high morbidity and mortality in swine and its recent spread into Western Europe and China highlights the urgent need to find a vaccine. Efficacy of vaccination with a DNA-protein cocktail of immunogenic ASFV antigens against virulent ASFV challenge with the Armenia 2007 strain in pigs was evaluated. Vaccinated animals had earlier onset of disease and death, and pathology tended to be more severe in vaccinees. A: Hemorrhagic lymphadenopathy, gastrohepatic lymph nodes (GHLN) with edema of the mesentery, common bile duct and gall bladder. B, C: Marked hemorrhage, edema and severe necrosis of lymphocytes (GHLN). These results indicate that a better understanding of detrimental immunopathological responses leading to ASFV pathology is important for the development of a safe and efficacious ASFV vaccine. View this paper
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Vaccines - ISSN 2076-393X