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Vaccines 2019, 7(1), 4; https://doi.org/10.3390/vaccines7010004

Should Pneumococcal Serotype 3 Be Included in Serotype-Specific Immunoassays?

1
Vaccine Evaluation Unit, Public Health England, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
2
UK Experimental Arthritis Treatment Centre for Children, Department of Women’s and Children’s Health, Institute of Translational Medicine (Child Health), University of Liverpool, Institute in the Park, Alder Hey Children’s NHS Foundation Trust Hospital, Eaton Road, Liverpool L12 2AP, UK
*
Author to whom correspondence should be addressed.
Received: 31 October 2018 / Revised: 21 December 2018 / Accepted: 2 January 2019 / Published: 3 January 2019
(This article belongs to the Special Issue Vaccines for Pneumococcal Infections)
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Abstract

Since the introduction of the 13-valent pneumococcal conjugate vaccine, a number of studies have demonstrated the limited efficacy of the pneumococcal serotype 3 component of this vaccine. Evidence from seven countries (Denmark, France, Greece, Portugal, Sweden, UK, US) shows limited or no effectiveness of the 13-valent pneumococcal conjugate vaccine against serotype 3 invasive pneumococcal disease and carriage. The serotype 3 capsule has some unique characteristics that may serve to explain this lack of efficacy—capsular polysaccharide is abundantly expressed, leading to a greater thickness of capsule, and free capsular polysaccharide may be released during growth. The serotype 3 component of the Luminex multiplex assay demonstrates inferior inter-laboratory reproducibility than other components and results may not be reliable. This communication outlines this evidence and discusses whether it is necessary to include serotype 3 in the assay in the future. View Full-Text
Keywords: Streptococcus pneumoniae; serotype 3; conjugate vaccine; multiplex; immunoassay Streptococcus pneumoniae; serotype 3; conjugate vaccine; multiplex; immunoassay
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Linley, E.; Bell, A.; Gritzfeld, J.F.; Borrow, R. Should Pneumococcal Serotype 3 Be Included in Serotype-Specific Immunoassays? Vaccines 2019, 7, 4.

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