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Vaccines 2019, 7(1), 22; https://doi.org/10.3390/vaccines7010022

Role of Type I Interferons on Filovirus Pathogenesis

1
Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
2
German Center for Infection Research, Partner Site, 20359 Hamburg, Germany
*
Author to whom correspondence should be addressed.
Received: 17 December 2018 / Revised: 6 February 2019 / Accepted: 15 February 2019 / Published: 20 February 2019
(This article belongs to the Special Issue Pathogen-Host Interactions: Implications for Vaccine Design)
Full-Text   |   PDF [252 KB, uploaded 20 February 2019]

Abstract

Filoviruses, such as Ebola and Marburg virus, encode viral proteins with the ability to counteract the type I interferon (IFN-I) response. These IFN-I antagonist proteins are crucial to ensure virus replication, prevent an antiviral state in infected and bystander cells, and impair the ability of antigen-presenting cells to initiate adaptive immune responses. However, in recent years, a number of studies have underscored the conflicting data between in vitro studies and in vivo data obtained in animal models and clinical studies during outbreaks. This review aims to summarize these data and to discuss the relative contributions of IFN-α and IFN-β to filovirus pathogenesis in animal models and humans. Finally, we evaluate the putative utilization of IFN-I in post-exposure therapy and its implications as a biomarker of vaccine efficacy. View Full-Text
Keywords: Interferon; filovirus; immune responses; pathogenicity Interferon; filovirus; immune responses; pathogenicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Escudero-Pérez, B.; Muñoz-Fontela, C. Role of Type I Interferons on Filovirus Pathogenesis. Vaccines 2019, 7, 22.

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