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Vaccines, Volume 13, Issue 4

April 2025 - 98 articles

Cover Story: This review provides a comprehensive overview of adenoviral (Ad) vector-based COVID-19 vaccines, exploring their biology, structure, immune responses, and clinical applications. It highlights the advantages of Ad vectors, such as strong immunity and scalable production, while addressing challenges like preexisting vector immunity and reduced efficacy against emerging variants. The review sheds light on innovative strategies, including vector redesign, alternative delivery methods, and multivalent approaches to enhance immune coverage and durability. It also emphasizes the need for next-generation Ad vaccines to ensure global preparedness against emerging SARS-CoV-2 variants. View this paper
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Vaccines - ISSN 2076-393XCreative Common CC BY license