Vaccines, Volume 10, Issue 7
2022 July - 183 articles
Cover Story: The many intricacies of Pseudomonas aeruginosa infections and their pathogenesis have rendered over 50 years of vaccine research unsuccessful. Complex opportunistic and nosocomial infections cause significant disease burden for patients and healthcare systems. With the increasingly frequent acquisition of resistant infections, and the gradual ineffectiveness of current treatments, the development of a preventative vaccine is becoming increasingly vital. Here, we provide an up-to-date review of the extensive history of vaccine development against P. aeruginosa. We discuss important progress in the preclinical research on novel antigen discovery, adjuvant use, and, furthermore, vaccine delivery systems that aims to develop a more efficacious vaccine. View this paper
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Vaccines - ISSN 2076-393X