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Vaccines, Volume 7, Issue 1

March 2019 - 33 articles

Cover Story: African swine fever virus (ASFV) causes high morbidity and mortality in swine and its recent spread into Western Europe and China highlights the urgent need to find a vaccine. Efficacy of vaccination with a DNA-protein cocktail of immunogenic ASFV antigens against virulent ASFV challenge with the Armenia 2007 strain in pigs was evaluated. Vaccinated animals had earlier onset of disease and death, and pathology tended to be more severe in vaccinees. A: Hemorrhagic lymphadenopathy, gastrohepatic lymph nodes (GHLN) with edema of the mesentery, common bile duct and gall bladder. B, C: Marked hemorrhage, edema and severe necrosis of lymphocytes (GHLN). These results indicate that a better understanding of detrimental immunopathological responses leading to ASFV pathology is important for the development of a safe and efficacious ASFV vaccine. View this paper
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Articles (33)

  • Review
  • Open Access
37 Citations
9,796 Views
15 Pages

29 January 2019

Streptococcus pneumoniae (S. pneumoniae, pneumococcus) is a major cause of morbidity and mortality worldwide. Achieving long-term immunity against S. pneumoniae through immunization is an important public health priority. Long-term protection after i...

  • Article
  • Open Access
112 Citations
9,009 Views
18 Pages

DNA-Protein Vaccination Strategy Does Not Protect from Challenge with African Swine Fever Virus Armenia 2007 Strain

  • Sun-Young Sunwoo,
  • Daniel Pérez-Núñez,
  • Igor Morozov,
  • Elena G. Sánchez,
  • Natasha N. Gaudreault,
  • Jessie D. Trujillo,
  • Lina Mur,
  • Marisa Nogal,
  • Daniel Madden and
  • Kinga Urbaniak
  • + 4 authors

28 January 2019

African swine fever virus (ASFV) causes high morbidity and mortality in swine (Sus scrofa), for which there is no commercially available vaccine. Recent outbreaks of the virus in Trans-Caucasus countries, Eastern Europe, Belgium and China highlight t...

  • Review
  • Open Access
30 Citations
12,336 Views
29 Pages

T-Cell Response to Viral Hemorrhagic Fevers

  • Federico Perdomo-Celis,
  • Maria S. Salvato,
  • Sandra Medina-Moreno and
  • Juan C. Zapata

22 January 2019

Viral hemorrhagic fevers (VHF) are a group of clinically similar diseases that can be caused by enveloped RNA viruses primarily from the families Arenaviridae, Filoviridae, Hantaviridae, and Flaviviridae. Clinically, this group of diseases has in com...

  • Review
  • Open Access
20 Citations
8,350 Views
20 Pages

21 January 2019

The current increase in vector-borne disease worldwide necessitates novel approaches to vaccine development targeted to pathogens delivered by blood-feeding arthropod vectors into the host skin. A concept that is gaining traction in recent years is t...

  • Review
  • Open Access
59 Citations
7,034 Views
18 Pages

19 January 2019

Non-serotype-specific protein-based pneumococcal vaccines have received extensive research focus due to the limitations of polysaccharide-based vaccines. Pneumococcal proteins (PnPs), universally expressed among serotypes, may induce broader immune r...

  • Communication
  • Open Access
3 Citations
3,376 Views
6 Pages

Measles at Work: Status of Measles Vaccination at a Multinational Company

  • Nora Moussli,
  • Emmanuel Kabengele and
  • Emilien Jeannot

16 January 2019

Background: This study aims to evaluate the status of measles vaccination among employees working for a multinational company. It also assesses the effectiveness of an on-site prevention campaign. In keeping with the guidelines of the World Health Or...

  • Review
  • Open Access
22 Citations
6,876 Views
28 Pages

Respiratory syncytial virus (RSV) is a significant cause of pediatric respiratory tract infections. It is estimated that two-thirds of infants are infected with RSV during the first year of life and it is one of the leading causes of death in this ag...

  • Article
  • Open Access
69 Citations
6,999 Views
11 Pages

Gonorrhea is a major global public health problem with emergence of multiple drug-resistant strains with no effective vaccine. This retrospective cohort study aimed to estimate the effectiveness of the New Zealand meningococcal B vaccine against gono...

  • Communication
  • Open Access
34 Citations
5,300 Views
10 Pages

Should Pneumococcal Serotype 3 Be Included in Serotype-Specific Immunoassays?

  • Ezra Linley,
  • Abigail Bell,
  • Jenna F. Gritzfeld and
  • Ray Borrow

Since the introduction of the 13-valent pneumococcal conjugate vaccine, a number of studies have demonstrated the limited efficacy of the pneumococcal serotype 3 component of this vaccine. Evidence from seven countries (Denmark, France, Greece, Portu...

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Vaccines - ISSN 2076-393X