Animal Vaccines: 2nd Edition

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Veterinary Vaccines".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 658

Special Issue Editors


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Guest Editor
International Program in Animal Vaccine Technology, International College, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan
Interests: cell-culture-based vaccine manufacturing process; bioreactor; oral DNA vaccine vector; animal vaccine
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Guest Editor
Department of Animal Sciences, The Ohio State University, Wooster Campus, 1680 Madison Avenue, Wooster, OH 44691, USA
Interests: virology, immunology and pathogenesis of diseases in large and companion animals; emerging viruses; RNA viruses; diagnostic virology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Scientists have attempted to use different kinds of novel technologies in animal vaccine development. Since the regulatory requirements of clinical trials for animal products are shorter than those in human vaccines, novel technologies are easier to commercialize in animal vaccine products. Many bacterial and eukaryotic cell-expressed recombinant proteins and viral vectors have been used for decades, and many kinds of immune potentiating materials, such as peptides, proteins, polymers, and emulsified oils, have been used in adjuvants. Biosafety and high immunization efficacy are the basic requirements of a vaccine. However, easily immunizing operations and low manufacturing costs are also essential for a successful animal vaccine product. This Special Issue will not only include novel antigen or adjuvant design but also cover large-scale production and manufacturing improvement technologies.

Dr. Hsian-Yu Wang
Prof. Dr. David Benfield
Guest Editors

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Keywords

  • animal vaccines
  • novel antigen or adjuvant design
  • vaccine technologies

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Published Papers (1 paper)

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Research

21 pages, 4108 KB  
Article
Respiratory Efficacy of a Multivalent Marker Vaccine Against Bovine Viral Diarrhoea Virus Types 1 and 2, Infectious Bovine Rhinotracheitis Virus, Bovine Respiratory Syncytial Virus, and Bovine Parainfluenza-3 Virus in Young Calves
by Carlos Montbrau, Marta Gibert, Marina Solé, Isabel Barril, Mercè Roca, Lucia Acal, Berta Vázquez, Joaquim Mallorqui and Ricard March
Vaccines 2025, 13(10), 999; https://doi.org/10.3390/vaccines13100999 - 24 Sep 2025
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Abstract
Background/Objectives: A new multivalent vaccine (DIVENCE® PENTA), containing Bovine viral diarrhoea virus (BVDV) types 1 and 2 recombinant proteins, live gE/tk double gene deleted Bovine Herpesvirus type 1 (BoHV-1 or IBR), live attenuated Bovine respiratory syncytial virus (BRSV) and inactivated parainfluenza-3 [...] Read more.
Background/Objectives: A new multivalent vaccine (DIVENCE® PENTA), containing Bovine viral diarrhoea virus (BVDV) types 1 and 2 recombinant proteins, live gE/tk double gene deleted Bovine Herpesvirus type 1 (BoHV-1 or IBR), live attenuated Bovine respiratory syncytial virus (BRSV) and inactivated parainfluenza-3 virus (PI-3) has been designed to protect cattle against the main viral pathogens associated with Bovine respiratory disease (BRD). The aim of this study was to demonstrate the efficacy of DIVENCE® PENTA against experimental infections with BVDV-1, BVDV-2, IBR, BRSV and PI-3 in young calves. Methods: Ten-week-old calves were given two intramuscular doses three weeks apart. The efficacy was evaluated by means of an experimental challenge three weeks after vaccination. Serology, clinical signs, rectal temperature, white blood cell count, viral shedding and lung lesions were monitored after the challenge. Results/Conclusions: The results demonstrated a significant sparing of BRD in calves vaccinated with DIVENCE® PENTA, as evidenced by fewer clinical signs, lower rectal temperatures, reduced viral shedding and less severe pulmonary lesions compared to control animals. A significant reduction in hyperthermia, leukopenia and viraemia post-challenge was also observed, highlighting the efficacy of the multivalent vaccine against BVDV types 1 and 2, IBR, BRSV and PI-3 in young calves. Full article
(This article belongs to the Special Issue Animal Vaccines: 2nd Edition)
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