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Vaccines, Volume 11, Issue 9

September 2023 - 117 articles

Cover Story: Group B streptococcus (GBS) is a leading cause of life-threatening neonatal infections and adverse pregnancy outcomes. It is classified into 10 different serotypes based on the capsular polysaccharide (CPS). No effective vaccine is clinically available. In this study by Wang et al., six conserved virulence factors involved in GBS pathogenesis at different stages were formulated as the GBSV6 vaccine. Intranasal GBSV6 immunization (i.n.) induced systemic and vaginal antibodies and T cell responses in mice. The immunity reduced mouse mortality and vaginal colonization by various GBS serotypes and protected newborns of immunized dams against the GBS challenge. The findings indicate that i.n. immunization targeting multiple conserved GBS virulence factors induces serotype-independent immunity, which protects against GBS infection systemically and vaginally in dams and prevents newborn deaths. View this paper
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Articles (117)

  • Article
  • Open Access
4 Citations
2,758 Views
12 Pages

Cemiplimab in Ultra-Octogenarian Patients with Cutaneous Squamous Cell Carcinoma: The Real-Life Experience of a Tertiary Referral Center

  • Nerina Denaro,
  • Emanuela Passoni,
  • Alice Indini,
  • Gianluca Nazzaro,
  • Giada Anna Beltramini,
  • Valentina Benzecry,
  • Giuseppe Colombo,
  • Carolina Cauchi,
  • Cinzia Solinas and
  • Mario Scartozzi
  • + 2 authors

18 September 2023

Background: The incidence of cutaneous squamous cell carcinoma (cSCC) is rapidly increasing, paralleling the aging of the population. cSCC predominantly affects chronically sun-exposed areas, such as the head and neck region. At our tertiary center,...

  • Article
  • Open Access
10 Citations
9,121 Views
14 Pages

18 September 2023

Many highly effective vaccines have been developed to protect dogs against disease caused by canine parvovirus, but despite this vaccine interference by maternally derived antibodies continues to cause immunisation failure. To help overcome this limi...

  • Article
  • Open Access
4 Citations
3,918 Views
14 Pages

Efficiency of NHEJ-CRISPR/Cas9 and Cre-LoxP Engineered Recombinant Turkey Herpesvirus Expressing Pasteurella multocida OmpH Protein for Fowl Cholera Prevention in Ducks

  • Nisachon Apinda,
  • Yongxiu Yao,
  • Yaoyao Zhang,
  • Anucha Muenthaisong,
  • Kanokwan Sangkakam,
  • Boondarika Nambooppha,
  • Amarin Rittipornlertrak,
  • Pongpisid Koonyosying,
  • Venugopal Nair and
  • Nattawooti Sthitmatee

18 September 2023

Fowl cholera is caused by the bacterium Pasteurella multocida, a highly transmissible avian ailment with significant global implications, leading to substantial economic repercussions. The control of fowl cholera outbreaks primarily relies on vaccina...

  • Article
  • Open Access
2 Citations
2,838 Views
12 Pages

A Field Efficacy Trial of Recombinant Porcine Circovirus Type 2d Vaccine in Three Herds

  • Lanjeong Ju,
  • Usharani Jayaramaiah,
  • Min-A Lee,
  • Young-Ju Jeong,
  • Su-Hwa You,
  • Hyang-Sim Lee,
  • Bang-Hun Hyun,
  • Nakhyung Lee and
  • Seok-Jin Kang

16 September 2023

This study aimed to evaluate the efficacy of a virus-like particle (VLP) vaccine containing the open reading frame 2 of porcine circovirus type 2d (PCV2d) in a farm environment where natural infections associated with porcine circovirus-associated di...

  • Article
  • Open Access
2 Citations
2,920 Views
13 Pages

Strategies and Trends in COVID-19 Vaccination Delivery: What We Learn and What We May Use for the Future

  • Giuseppe Tradigo,
  • Jayanta Kumar Das,
  • Patrizia Vizza,
  • Swarup Roy,
  • Pietro Hiram Guzzi and
  • Pierangelo Veltri

16 September 2023

Vaccination has been the most effective way to control the outbreak of the COVID-19 pandemic. The numbers and types of vaccines have reached considerable proportions, even if the question of vaccine procedures and frequency still needs to be resolved...

  • Systematic Review
  • Open Access
5 Citations
2,459 Views
24 Pages

Vaccinating Welders against Pneumococcus: Evidence from a Systematic Review and Meta-Analysis

  • Matteo Riccò,
  • Pietro Ferraro,
  • Salvatore Zaffina,
  • Vincenzo Camisa,
  • Federico Marchesi and
  • Davide Gori

15 September 2023

Workers occupationally exposed to welding dusts and fumes have been suspected to be at increased risk of invasive pneumococcal disease (IPD). Since the 2010s, the United Kingdom Department of Health and the German Ständige Impfkommission (STIKO)...

  • Article
  • Open Access
7 Citations
2,079 Views
15 Pages

15 September 2023

The S-protein is the major antigen of the SARS-CoV-2 virus, against which protective antibodies are generated. The S-protein gene was used in adenoviral vectors and mRNA vaccines against COVID-19. While the primary function of antibodies is to bind t...

  • Article
  • Open Access
1 Citations
4,397 Views
9 Pages

The Effectiveness of Paracetamol to Reduce the Post-Vaccination SARS-CoV-2 Adverse Effects in an Italian Vaccination Center

  • Eleonora Ricci,
  • Anamaria Glavasc,
  • Barbara Morandini,
  • Maria Caterina Grassi and
  • Giuseppe La Torre

15 September 2023

The arrival of specific vaccines was crucial for the eradication of COVID-19. Despite the security of the vaccination, the administration of COVID-19 mRNA vaccines often causes systemic side effects for a short time after the injection, such as heada...

  • Article
  • Open Access
4 Citations
6,104 Views
14 Pages

Stimulation of Potent Humoral and Cellular Immunity via Synthetic Dual-Antigen MVA-Based COVID-19 Vaccine COH04S1 in Cancer Patients Post Hematopoietic Cell Transplantation and Cellular Therapy

  • Flavia Chiuppesi,
  • Sandra Ortega-Francisco,
  • Miguel-Angel Gutierrez,
  • Jing Li,
  • Minh Ly,
  • Katelyn Faircloth,
  • Jada Mack-Onyeike,
  • Corinna La Rosa,
  • Sandra Thomas and
  • Qiao Zhou
  • + 27 authors

15 September 2023

Hematopoietic cell transplantation (HCT) and chimeric antigen receptor (CAR)-T cell patients are immunocompromised, remain at high risk following SARS-CoV-2 infection, and are less likely than immunocompetent individuals to respond to vaccination. As...

  • Article
  • Open Access
13 Citations
3,722 Views
9 Pages

HPV Vaccination in Immunosuppressed Patients with Established Skin Warts and Non-Melanoma Skin Cancer: A Single-Institutional Cohort Study

  • Simon Bossart,
  • Cloé Daneluzzi,
  • Matthias B. Moor,
  • Cédric Hirzel,
  • Kristine Heidemeyer,
  • S. Morteza Seyed Jafari,
  • Robert E. Hunger and
  • Daniel Sidler

15 September 2023

cSCC (cutaneous squamous cell carcinoma) and its precursors are a major cause of morbidity, especially in immunosuppressed patients, and are frequently associated with human papillomavirus (HPV) infections. The purpose of this study is to investigate...

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Vaccines - ISSN 2076-393X