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Antioxidants, Volume 13, Issue 10

October 2024 - 123 articles

Cover Story: Alzheimer’s disease (AD) is a neurodegenerative process caused by the aggregation of amyloid β-peptide (Aβ) into oligomers and fibrils, leading to synaptic toxicity and neuronal death. This review explores the link between oxidative stress, inflammation, and AD progression. Oxidative stress involving free radicals and redox metals induces mitochondrial dysfunction and damages biomolecules through oxidation and nitration. Astroglia and microglia, being sources of proinflammatory factors and oxidative stress, cause inflammation. These pathological mechanisms also affect the blood–brain barrier, compromising its integrity and function, and damage oligodendrocytes, impairing physiological–electrical transmission. Therapies targeting oxidative stress and inflammation are also reviewed. View this paper
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Articles (123)

  • Article
  • Open Access
3 Citations
2,576 Views
26 Pages

Integrative Human Genetic and Cellular Analysis of the Pathophysiological Roles of AnxA2 in Alzheimer’s Disease

  • Lianmeng Ye,
  • Jiazheng Zhao,
  • Zhengpan Xiao,
  • Wenyu Gu,
  • Xiaoxuan Liu,
  • Nuela Manka’a Che Ajuyo,
  • Yi Min,
  • Yechun Pei and
  • Dayong Wang

21 October 2024

Alzheimer’s disease (AD) is an intractable and progressive neurodegenerative disease. Amyloid beta (Aβ) aggregation is the hallmark of AD. Aβ induces neurotoxicity through a variety of mechanisms, including interacting with membrane r...

  • Article
  • Open Access
2 Citations
1,389 Views
16 Pages

Effect of Different Salinities on the Biochemical Properties and Meat Quality of Adult Freshwater Drum (Aplodinotus grunniens) During Temporary Rearing

  • Wanwen Chen,
  • Sharifa Mohamed Miraji,
  • Yu Tian,
  • Xueyan Ma,
  • Wu Jin,
  • Haibo Wen,
  • Gangchun Xu,
  • Pao Xu and
  • Hao Cheng

21 October 2024

Salinity is a significant environmental component that affects the physiological state of aquatic species. This study aimed to investigate whether water salinity had an impact on the biochemical properties and meat quality of adult Aplodinotus grunni...

  • Article
  • Open Access
5 Citations
2,343 Views
15 Pages

21 October 2024

Background: T-006, a novel neuroprotective derivative of tetramethylpyrazine (TMP), exhibits multifunctional neuroprotective properties. T-006 has been shown to improve neurological and behavioral functions in animal models of ischemic stroke and neu...

  • Article
  • Open Access
2 Citations
2,189 Views
18 Pages

19 October 2024

Massa Medicata Fermentata (MMF) is a naturally fermented product used to treat indigestion and increase stomach activity in traditional medicine. This study examined the ability of the hydrothermal extract of MMF to scavenge free radicals correspondi...

  • Review
  • Open Access
41 Citations
3,509 Views
21 Pages

Modulation of NRF2/KEAP1 Signaling by Phytotherapeutics in Periodontitis

  • Giovanni Tossetta,
  • Sonia Fantone,
  • Lucrezia Togni,
  • Andrea Santarelli,
  • Fabiola Olivieri,
  • Daniela Marzioni and
  • Maria Rita Rippo

18 October 2024

Periodontitis affects up to 40% of adults over 60 years old and is a consequence of gingivitis. Periodontitis is characterized by a chronic inflammation, periodontal damage, and alveolar bone resorption. The nuclear factor erythroid 2-related factor...

  • Article
  • Open Access
4 Citations
2,504 Views
17 Pages

Astaxanthin Supplementation Effects in Right Ventricle of Rats Exposed to Chronic Intermittent Hypobaric Hypoxia

  • Eduardo Pena,
  • Samia El Alam,
  • Constanza Gonzalez,
  • Isaac Cortés,
  • Diego Aguilera,
  • Karen Flores and
  • Karem Arriaza

18 October 2024

In Chile, individuals are commonly exposed to high altitude due to the work shift system, involving days of exposure to high altitude followed by days at sea level over the long term, which can result in chronic intermittent hypobaric hypoxia (CIHH)....

  • Article
  • Open Access
2 Citations
3,247 Views
18 Pages

Microplastic-Enhanced Cadmium Toxicity: A Growing Threat to the Sea Grape, Caulerpa lentillifera

  • Weilong Zhou,
  • Haolong Zheng,
  • Yingyin Wu,
  • Junyi Lin,
  • Xiaofei Ma,
  • Yixuan Xing,
  • Huilong Ou,
  • Hebert Ely Vasquez,
  • Xing Zheng and
  • Feng Yu
  • + 1 author

18 October 2024

The escalating impact of human activities has led to the accumulation of microplastics (MPs) and heavy metals in marine environments, posing serious threats to marine ecosystems. As essential components of oceanic ecosystems, large seaweeds such as C...

  • Article
  • Open Access
4 Citations
2,450 Views
32 Pages

Deciphering the Landscape of GATA-Mediated Transcriptional Regulation in Gastric Cancer

  • Rodiola Begolli,
  • Anastasia Patouna,
  • Periklis Vardakas,
  • Anastasia Xagara,
  • Kleanthi Apostolou,
  • Demetrios Kouretas and
  • Antonis Giakountis

18 October 2024

Gastric cancer (GC) is an asymptomatic malignancy in early stages, with an invasive and cost-ineffective diagnostic toolbox that contributes to severe global mortality rates on an annual basis. Ectopic expression of the lineage survival transcription...

  • Article
  • Open Access
1,175 Views
15 Pages

Radical Scavenging Capacity and In Vitro Cytoprotective Effects of Great Salt Lake-Derived Processed Mineral Water

  • Takayuki Mokudai,
  • Seiko Nakagawa,
  • Hiroyasu Kanetaka,
  • Kazuo Oda,
  • Hiroya Abe and
  • Yoshimi Niwano

18 October 2024

The Great Salt Lake, located in Utah, USA, is a saltwater lake with no outlet and is surrounded by vast mountains and salt deserts. We aimed to use Great Salt Lake-derived processed mineral water (hereafter termed as GSL-MW) for maintaining oral heal...

  • Article
  • Open Access
6 Citations
2,278 Views
24 Pages

Rosmarinic Acid Attenuates Salmonella enteritidis-Induced Inflammation via Regulating TLR9/NF-κB Signaling Pathway and Intestinal Microbiota

  • Dandan Yi,
  • Menghui Wang,
  • Xia Liu,
  • Lanqian Qin,
  • Yu Liu,
  • Linyi Zhao,
  • Ying Peng,
  • Zhengmin Liang and
  • Jiakang He

18 October 2024

Salmonella enteritidis (SE) infection disrupts the homeostasis of the intestinal microbiota, causing an intestinal inflammatory response and posing a great threat to human and animal health. The unreasonable use of antibiotics has led to an increase...

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Antioxidants - ISSN 2076-3921