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Antioxidants, Volume 11, Issue 2

February 2022 - 259 articles

Cover Story: Průchová et al. used mitochondria isolated from wild-type and phospholipase A (iPLA) ablated mice to demonstrate that tert-butylhydroperoxide (TBHP) activates iPLA, with consequent liberation of fatty acids (FAs) and lysophospholipids. The released FAs interact with the adenine nucleotide translocase, leading to increased proton transport across the inner mitochondrial membrane and consequent attenuation of mitochondrial superoxide production. Detailed lipidomic analysis reveals a typical glycerophospholipid cleavage pattern for TBHP-activated iPLA and clarifies the role of iPLA in cardiolipin remodeling in the brain. Moreover, iPLA-KO mice were more sensitive to stimulation by pro-inflammatory lipopolysaccharide, supporting the antioxidant and anti-inflammatory role of iPLA in vivo. View this paper

Articles (259)

  • Article
  • Open Access
25 Citations
5,116 Views
21 Pages

21 February 2022

Red clover is the subject of numerous studies because of its antioxidant properties, the positive influence of isoflavones on the health, and its potential use in the prevention and treatment of chronic diseases. The right excipients, such as cyclode...

  • Article
  • Open Access
13 Citations
4,750 Views
17 Pages

Reactive Oxygen Species Differentially Modulate the Metabolic and Transcriptomic Response of Endothelial Cells

  • Niklas Müller,
  • Timothy Warwick,
  • Kurt Noack,
  • Pedro Felipe Malacarne,
  • Arthur J. L. Cooper,
  • Norbert Weissmann,
  • Katrin Schröder,
  • Ralf P. Brandes and
  • Flávia Rezende

21 February 2022

Reactive oxygen species (ROS) are important mediators of both physiological and pathophysiological signal transduction in the cardiovascular system. The effects of ROS on cellular processes depend on the concentration, localization, and duration of e...

  • Article
  • Open Access
21 Citations
4,150 Views
21 Pages

21 February 2022

Honeysuckles are frost tolerant plants providing early-ripening fruits with health-promoting properties which have been used in traditional medicine in China. This study evaluates the impact of the climatic conditions of two areas on the chemical com...

  • Article
  • Open Access
25 Citations
6,347 Views
17 Pages

Supplementation with a Cocoa–Carob Blend, Alone or in Combination with Metformin, Attenuates Diabetic Cardiomyopathy, Cardiac Oxidative Stress and Inflammation in Zucker Diabetic Rats

  • Esther García-Díez,
  • María Elvira López-Oliva,
  • Alicia Caro-Vadillo,
  • Francisco Pérez-Vizcaíno,
  • Jara Pérez-Jiménez,
  • Sonia Ramos and
  • María Ángeles Martín

21 February 2022

Diabetic cardiomyopathy (DCM) is one of the main causes of mortality among diabetic patients, with oxidative stress and inflammation major contributors to its development. Dietary flavonoids show strong antioxidant and anti-inflammatory activities, a...

  • Review
  • Open Access
14 Citations
6,018 Views
14 Pages

Phytochemical Contents and Pharmacological Potential of Parkia speciosa Hassk. for Diabetic Vasculopathy: A Review

  • Ahmad Khusairi Azemi,
  • Muhammad Luqman Nordin,
  • Kamarul Ariffin Hambali,
  • Nur Amalina Noralidin,
  • Siti Safiah Mokhtar and
  • Aida Hanum Ghulam Rasool

21 February 2022

Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and is considered a major health problem in the world. It is associated with endothelial dysfunction which causes progressive vascular damage. DM is a known risk factor for...

  • Review
  • Open Access
37 Citations
8,139 Views
23 Pages

21 February 2022

Oxidative stress, resulting from an imbalance between the formation of damaging free radicals and availability of protective antioxidants, can contribute to peripheral neuropathic pain conditions. Reactive oxygen and nitrogen species, as well as prod...

  • Review
  • Open Access
30 Citations
4,861 Views
14 Pages

Metabolism, Mitochondrial Dysfunction, and Redox Homeostasis in Pulmonary Hypertension

  • Daniel Colon Hidalgo,
  • Hanan Elajaili,
  • Hagir Suliman,
  • Marjorie Patricia George,
  • Cassidy Delaney and
  • Eva Nozik

21 February 2022

Pulmonary hypertension (PH) represents a group of disorders characterized by elevated mean pulmonary artery (PA) pressure, progressive right ventricular failure, and often death. Some of the hallmarks of pulmonary hypertension include endothelial dys...

  • Review
  • Open Access
48 Citations
12,652 Views
10 Pages

21 February 2022

SOD1 is the major superoxide dismutase responsible for catalyzing dismutation of superoxide to hydrogen peroxide and molecular oxygen. It is well known as an essential antioxidant enzyme for maintaining cellular redox homeostasis. SOD1 dysregulation...

  • Article
  • Open Access
20 Citations
3,532 Views
17 Pages

Vasoactive Properties of a Cocoa Shell Extract: Mechanism of Action and Effect on Endothelial Dysfunction in Aged Rats

  • Pilar Rodríguez-Rodríguez,
  • Kendal Ragusky,
  • Sophida Phuthong,
  • Santiago Ruvira,
  • David Ramiro-Cortijo,
  • Silvia Cañas,
  • Miguel Rebollo-Hernanz,
  • María Dolores Morales,
  • Ángel L. López de Pablo and
  • María A. Martín-Cabrejas
  • + 1 author

21 February 2022

Cocoa has cardiovascular beneficial effects related to its content of antioxidant phytochemicals. Cocoa manufacturing produces large amounts of waste, but some by-products may be used as ingredients with health-promoting potential. We aimed to invest...

  • Article
  • Open Access
26 Citations
4,273 Views
13 Pages

21 February 2022

Ursolic acid (UA) is a bioactive molecule widely distributed in various fruits and vegetables, which was reported to play a therapeutic role in ulcerative colitis (UC) induced by toxic chemicals. However, the underlying mechanism has not been well cl...

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Antioxidants - ISSN 2076-3921