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Antioxidants, Volume 11, Issue 2

February 2022 - 259 articles

Cover Story: Průchová et al. used mitochondria isolated from wild-type and phospholipase A (iPLA) ablated mice to demonstrate that tert-butylhydroperoxide (TBHP) activates iPLA, with consequent liberation of fatty acids (FAs) and lysophospholipids. The released FAs interact with the adenine nucleotide translocase, leading to increased proton transport across the inner mitochondrial membrane and consequent attenuation of mitochondrial superoxide production. Detailed lipidomic analysis reveals a typical glycerophospholipid cleavage pattern for TBHP-activated iPLA and clarifies the role of iPLA in cardiolipin remodeling in the brain. Moreover, iPLA-KO mice were more sensitive to stimulation by pro-inflammatory lipopolysaccharide, supporting the antioxidant and anti-inflammatory role of iPLA in vivo. View this paper

Articles (259)

  • Article
  • Open Access
24 Citations
5,991 Views
19 Pages

19 February 2022

Reactive oxygen species (ROS) are generated during intrinsic (chronological aging) and extrinsic (photoaging) skin aging. Therefore, antioxidants that inhibit ROS production may be involved in delaying skin aging. In this study, we investigated the p...

  • Article
  • Open Access
11 Citations
6,225 Views
17 Pages

Effect of Crushing Peanuts on Fatty Acid and Phenolic Bioaccessibility: A Long-Term Study

  • Isabella Parilli-Moser,
  • Inés Domínguez-López,
  • Camila Arancibia-Riveros,
  • María Marhuenda-Muñoz,
  • Anna Vallverdú-Queralt,
  • Sara Hurtado-Barroso and
  • Rosa M. Lamuela-Raventós

19 February 2022

Background: Peanuts are consumed worldwide and have been linked to multiple health benefits. Processing may affect the bioavailability of peanut bioactive compounds. Therefore, we aim to evaluate the effects of crushing peanuts on the bioavailability...

  • Article
  • Open Access
9 Citations
3,907 Views
11 Pages

Measurement of Redox Biomarkers in the Whole Blood and Red Blood Cell Lysates of Dogs

  • Luis G. González-Arostegui,
  • Alberto Muñoz-Prieto,
  • Asta Tvarijonaviciute,
  • José Joaquín Cerón and
  • Camila Peres Rubio

19 February 2022

The evaluation of the biomarkers of oxidative status is usually performed in serum, however, other samples, such as red blood cells (RBCs) lysates or whole blood (WB), can be used. The objective of this study was to evaluate if a comprehensive panel...

  • Article
  • Open Access
14 Citations
3,520 Views
13 Pages

19 February 2022

Lipophilic grape seed proanthocyanidin (LGSP) synthesized from GSP and lauric acid exhibits an excellent antioxidant and anti-inflammatory effect. However, its anti-cervical cancer activity is still unknown. In this study, the in vitro anti-cervical...

  • Article
  • Open Access
24 Citations
3,498 Views
10 Pages

Medicarpin Increases Antioxidant Genes by Inducing NRF2 Transcriptional Level in HeLa Cells

  • Jung-Hwan Kim,
  • Dong-Min Kang,
  • Young-Jin Cho,
  • Jin-Won Hyun and
  • Mi-Jeong Ahn

18 February 2022

The nuclear factor erythroid-derived 2-related factor 2 (NRF2) plays a pivotal role in the regulation of genes involved in oxidative stress and drug detoxification. Therefore, it is important to find NRF2 inducers to protect cells from excessive oxid...

  • Article
  • Open Access
5 Citations
3,006 Views
15 Pages

Neurolocomotor Behavior and Oxidative Stress Markers of Thiazole and Thiazolidinedione Derivatives against Nauphoeta cinerea

  • Pedro Silvino Pereira,
  • Adrielle Rodrigues Costa,
  • Thalyta Julyanne Silva de Oliveira,
  • Carlos Vinícius Barros Oliveira,
  • Maria do Carmo Alves de Lima,
  • Jamerson Ferreira de Oliveira,
  • Bonglee Kim,
  • Henrique D. M. Coutinho,
  • Antonia Eliene Duarte and
  • Jean Paul Kamdem
  • + 1 author

18 February 2022

Thiazolidine compounds NJ20 {(E)-2-(2-(5-bromo-2-methoxybenzylidene)hydrazinyl)-4-(4-nitrophenyl)thiazole} and NW05 [(2-(benzo (d) (1,3) dioxol-4-ylmethylene)-N-(4-bromophenyl)-thiosemicarbazone] potentiated the effect of norfloxacin in resistant bac...

  • Article
  • Open Access
9 Citations
2,698 Views
15 Pages

CoenzymeQ10 and Ischemic Preconditioning Potentially Prevent Tourniquet-Induced Ischemia/Reperfusion in Knee Arthroplasty, but Combined Pretreatment Possibly Neutralizes Their Beneficial Effects

  • Prangmalee Leurcharusmee,
  • Passakorn Sawaddiruk,
  • Yodying Punjasawadwong,
  • Nantawit Sugundhavesa,
  • Kasisin Klunklin,
  • Siam Tongprasert,
  • Patraporn Sitilertpisan,
  • Thidarat Jaiwongkam,
  • Nattayaporn Apaijai and
  • Nipon Chattipakorn
  • + 1 author

18 February 2022

Tourniquet (TQ) use during total knee arthroplasty (TKA) induces ischemia/reperfusion (I/R) injury, resulting in mitochondrial dysfunction. This study aims to determine the effects of coenzyme Q10 (CoQ10) and ischemic preconditioning (IPC), either al...

  • Article
  • Open Access
6 Citations
3,759 Views
17 Pages

Stabilization of PE with Pomegranate Extract: Contradictions and Possible Mechanisms

  • Dóra Tátraaljai,
  • Yun Tang,
  • Emese Pregi,
  • Erika Vági,
  • Viola Horváth and
  • Béla Pukánszky

18 February 2022

Dry pomegranate peel was extracted with acetone and the extract was added to a Phillips type polyethylene. The concentration of the extract was changed from 0 to 1000 ppm in six steps and stabilization efficiency was checked by the multiple extrusion...

  • Article
  • Open Access
19 Citations
4,415 Views
22 Pages

Impact of Seminal Plasma Antioxidants on Donkey Sperm Cryotolerance

  • Jaime Catalán,
  • Iván Yánez-Ortiz,
  • Asta Tvarijonaviciute,
  • Luis Guillermo González-Arostegui,
  • Camila P. Rubio,
  • Marc Yeste,
  • Jordi Miró and
  • Isabel Barranco

18 February 2022

This study investigated whether the activities of the antioxidant components of donkey seminal plasma (SP)—both enzymatic (superoxide dismutase (SOD), catalase-like (CAT), glutathione peroxidase-like (GPX), and paraoxonase type 1 (PON1)) and no...

  • Review
  • Open Access
29 Citations
8,070 Views
50 Pages

18 February 2022

In the last twenty years, significant progress in understanding the pathophysiology of age-associated neurodegenerative diseases has been made. However, the prevention and treatment of these diseases remain without clinically significant therapeutic...

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Antioxidants - ISSN 2076-3921