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Brain Sciences, Volume 10, Issue 5

May 2020 - 68 articles

Cover Story: We aimed to clarify the effect of the type and number of adverse childhood experiences (ACE) and the timing of adverse experiences on clinical outcomes in 2,675 patients with bipolar disorders. We found that ACE have robust negative effects on clinical outcomes, including earlier age at onset, presence of psychotic episodes, suicide attempts, mixed symptoms, substance misuse comorbidity, and worse life functioning. Specifically, the number of ACE had the most significant effect on clinical outcomes; however, specific ACE, such as physical abuse, had a considerable influence. Moreover, post-childhood adverse experiences had a weaker effect on clinical outcomes than ACE.View this paper.
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Articles (68)

  • Article
  • Open Access
34 Citations
7,480 Views
16 Pages

Background: Non-Hispanic Black (NHB) youth are at a higher risk of high-risk behaviors compared to non-Hispanic White (NHW) youth. Some of this racial gap is shown to be due to weaker effects of parental educational attainment on reducing the prevale...

  • Review
  • Open Access
13 Citations
5,641 Views
20 Pages

Update on Atypicalities of Central Nervous System in Autism Spectrum Disorder

  • Ahmad Naqib Shuid,
  • Putri Ayu Jayusman,
  • Nazrun Shuid,
  • Juriza Ismail,
  • Norazlin Kamal Nor and
  • Isa Naina Mohamed

Autism spectrum disorder (ASD) is a heterogeneous, behaviorally defined, neurodevelopmental disorder that has been modeled as a brain-based disease. The behavioral and cognitive features of ASD are associated with pervasive atypicalities in the centr...

  • Review
  • Open Access
45 Citations
5,158 Views
12 Pages

In the Russian Federation, multiple sclerosis prevalence rates vary from 10 to 80 cases per 100,000, depending on region and the nationality of the population. The main characteristics of multiple sclerosis epidemiology in the XX century in this big...

  • Article
  • Open Access
35 Citations
6,695 Views
14 Pages

Anhedonia to Gentle Touch in Fibromyalgia: Normal Sensory Processing but Abnormal Evaluation

  • Rebecca Boehme,
  • Helene van Ettinger-Veenstra,
  • Håkan Olausson,
  • Björn Gerdle and
  • Saad S. Nagi

Social touch is important for interpersonal interaction. Gentle touch and slow brushing are typically perceived as pleasant, the degree of pleasantness is linked to the activity of the C-tactile (CT) fibers, a class of unmyelinated nerves in the skin...

  • Article
  • Open Access
17 Citations
6,984 Views
24 Pages

Auditory and Visual Response Inhibition in Children with Bilateral Hearing Aids and Children with ADHD

  • Laura Bell,
  • Wolfgang Scharke,
  • Vanessa Reindl,
  • Janina Fels,
  • Christiane Neuschaefer-Rube and
  • Kerstin Konrad

Children fitted with hearing aids (HAs) and children with attention deficit/hyperactivity disorder (ADHD) often have marked difficulties concentrating in noisy environments. However, little is known about the underlying neural mechanism of auditory a...

  • Article
  • Open Access
12 Citations
4,821 Views
13 Pages

Disentangling Restrictive and Repetitive Behaviors and Social Impairments in Children and Adolescents with Gilles de la Tourette Syndrome and Autism Spectrum Disorder

  • Mariangela Gulisano,
  • Rita Barone,
  • Salvatore Alaimo,
  • Alfredo Ferro,
  • Alfredo Pulvirenti,
  • Lara Cirnigliaro,
  • Selena Di Silvestre,
  • Serena Martellino,
  • Nicoletta Maugeri and
  • Maria Chiara Milana
  • + 2 authors

Gilles de la Tourette syndrome (GTS) and autism spectrum disorder (ASD) are two neurodevelopmental disorders with male predominance, frequently comorbid, that share clinical and behavioral features. The incidence of ASD in patients affected by GTS wa...

  • Article
  • Open Access
12 Citations
5,169 Views
11 Pages

Transcranial direct current stimulation (tDCS) has been shown to support cognition and brain function in older adults. However, there is an absence of research specifically designed to determine optimal stimulation protocols, and much of what is know...

  • Article
  • Open Access
3 Citations
3,391 Views
10 Pages

Milnacipran is a reuptake inhibitor of both serotonin and noradrenaline, used in the treatment of fibromyalgia with severe depression. However, few studies have been conducted on the efficacies of milnacipran drug on the functional connectivity of th...

  • Case Report
  • Open Access
12 Citations
5,667 Views
11 Pages

Post-stroke sensorimotor deficits impair voluntary movements. This impairment may alter a person’s sense of agency, which is the awareness of controlling one’s actions. A previous study showed that post-stroke patients incorrectly aligned...

  • Case Report
  • Open Access
45 Citations
10,577 Views
13 Pages

Stroke is a neurologic disorder considered the first cause of disability worldwide due to motor, cognitive, and sensorial sequels. Balance dysfunctions in stroke survivors increase the risk of falls and physiotherapeutic rehabilitation is essential t...

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Brain Sci. - ISSN 2076-3425Creative Common CC BY license