Anhedonia to Gentle Touch in Fibromyalgia: Normal Sensory Processing but Abnormal Evaluation
Depression and Anxiety: The Significance of Touch in Psychiatry—Clinical and Neuroscientific Approaches
)
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Background Data
2.2.1. Pain Intensity Aspects
2.2.2. Psychological Distress
2.2.3. Sleeping Problems
2.2.4. Pain Catastrophizing Scale (PCS)
2.2.5. Impact of the Pain Aspects
2.2.6. The European Quality of Life Instrument (EQ-5D)
2.2.7. Pharmacological Treatments
2.3. Stimuli and Procedures
2.3.1. Task
2.3.2. MRI
2.3.3. Analysis
2.3.4. VBM
3. Results
3.1. Clinical Characteristics
3.2. Behavior
3.3. Functional Imaging
3.4. Voxel-Based Morphometry
4. Discussion
4.1. Behavior
4.2. Functional Imaging
4.3. VBM
4.4. Limitations and Future Direction
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Group | HC | n = 29 | FM | n = 31 | Statistics |
---|---|---|---|---|---|
Variables | Mean | SD | Mean | SD | p-Value |
Age (years) | 42.7 | 10.1 | 39.2 | 11.4 | 0.219 |
Systolic BP (mm Hg) | 113.2 | 8.8 | 121.5 | 12.9 | 0.006 |
Diastolic BP (mm Hg) | 75.3 | 8.5 | 80.6 | 10.6 | 0.040 |
Number of tender points | 0.3 | 0.9 | 16.7 | 1.5 | <0.001 |
FM duration (years) | 4.4 | 5.0 | NA | ||
Height (m) | 1.69 | 0.06 | 1.66 | 0.06 | 0.090 |
Weight (kg) | 68.4 | 10.9 | 81.4 | 19.2 | 0.002 |
BMI (kg/m2) | 23.8 | 3.1 | 29.3 | 6.3 | <0.001 |
Pain intensity current | 0.0 | 0.0 | 5.7 | 1.8 | <0.001 |
Pain intensity 4w | 0.0 | 0.0 | 5.9 | 1.8 | <0.001 |
HADS-Depression | 1.4 | 1.7 | 6.0 | 3.6 | <0.001 |
HADS-Anxiety | 2.6 | 2.3 | 7.8 | 4.0 | <0.001 |
PCS | 11.8 | 9.2 | 20.3 | 10.5 | 0.001 |
ISI | 4.5 | 4.5 | 13.4 | 5.9 | <0.001 |
Pain hindrance ADL | 5.7 | 2.3 | NA | ||
Pain hindrance leisure | 5.7 | 2.5 | NA | ||
Pain hindrance work | 4.9 | 2.7 | NA | ||
EQ-VAS | 86.8 | 7.8 | 53.3 | 19.5 | <0.001 |
Region | x | y | z | Hemi-Sphere | Cluster Size | t | p |
---|---|---|---|---|---|---|---|
Hippocampus | 36 | −22.5 | −18 | Right | 469 | 4.98 | >0.0001 |
Parahippocampal Gyrus | 37.5 | −31.5 | −12 | Right | 4.68 | >0.0001 | |
24 | −19.5 | −9 | 3.91 | 0.0001 | |||
−24 | −19.5 | −16.5 | Left | 146 | 3.94 | 0.0002 | |
Middle Frontal Gyrus | 31.5 | 45 | 22.5 | Right | 233 | 4.69 | >0.0001 |
Rectal Gyrus | 3 | 37.5 | −28.5 | Right | 339 | 4.51 | >0.0001 |
Uncus | 34.5 | 0 | −34.5 | Right | 505 | 4.43 | >0.0001 |
−34.5 | 1.5 | −28.5 | Left | 215 | 3.69 | 0.0003 | |
Superior Temporal Gyrus | 46.5 | 0 | −16.5 | Right | 3.91 | 0.0001 | |
−40.5 | 6 | −18 | Left | 3.49 | 0.0005 | ||
Subcallosal Gyrus | 13.5 | 6 | −19.5 | Right | 288 | 4.29 | >0.0001 |
Anterior Cingulate | 9 | 18 | −12 | Right | 3.51 | 0.0004 | |
Anterior Insula | −28.5 | 21 | 1.5 | Left | 764 | 4.20 | >0.0001 |
27 | 25.5 | 0 | Right | 430 | 4.13 | 0.0001 | |
Middle Occipital Gyrus | −22.5 | −88.5 | 4.5 | Left | 175 | 4.18 | 0.0001 |
Inferior Frontal Gyrus | 37.5 | 24 | −1.5 | Right | 3.77 | 0.0002 | |
Cingulate Gyrus | −6 | −10.5 | 43.5 | Left | 131 | 4.07 | 0.0001 |
−9 | −10.5 | 36 | 3.72 | 0.0001 | |||
Cerebellum | −22.5 | −31.5 | −33 | Left | 72 | 3.69 | 0.0003 |
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Boehme, R.; van Ettinger-Veenstra, H.; Olausson, H.; Gerdle, B.; Nagi, S.S. Anhedonia to Gentle Touch in Fibromyalgia: Normal Sensory Processing but Abnormal Evaluation. Brain Sci. 2020, 10, 306. https://doi.org/10.3390/brainsci10050306
Boehme R, van Ettinger-Veenstra H, Olausson H, Gerdle B, Nagi SS. Anhedonia to Gentle Touch in Fibromyalgia: Normal Sensory Processing but Abnormal Evaluation. Brain Sciences. 2020; 10(5):306. https://doi.org/10.3390/brainsci10050306
Chicago/Turabian StyleBoehme, Rebecca, Helene van Ettinger-Veenstra, Håkan Olausson, Björn Gerdle, and Saad S. Nagi. 2020. "Anhedonia to Gentle Touch in Fibromyalgia: Normal Sensory Processing but Abnormal Evaluation" Brain Sciences 10, no. 5: 306. https://doi.org/10.3390/brainsci10050306
APA StyleBoehme, R., van Ettinger-Veenstra, H., Olausson, H., Gerdle, B., & Nagi, S. S. (2020). Anhedonia to Gentle Touch in Fibromyalgia: Normal Sensory Processing but Abnormal Evaluation. Brain Sciences, 10(5), 306. https://doi.org/10.3390/brainsci10050306