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Microorganisms, Volume 8, Issue 2

2020 February - 169 articles

Cover Story: The reduction of antimicrobial resistance is a major challenge. The withdrawal of antibiotics for growth promotion and prevention of disease in animals is essential avoiding resistances, but this may decrease productivity and affect poultry health due to an increase of gut inflammation. Probiotics are promising products for addressing this challenge due to their beneficial effects on microbiota, mucosal barrier, and immune system to control inflammation. The specific effects that a probiotic should induce on the host to maximize productivity and health have not yet been identified. Firstly, it may be necessary to define the optimal innate immune response in the gut that optimizes productivity and health and to then investigate probiotic strain able to induce these specific responses. Understanding the gaps in host–microbiota–pathogen interaction and related mechanisms involved in the inflammatory response is the cornerstone selecting probiotics by their mode of action.
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  • Articles (169)

    • Article
    • Open Access
    12 Citations
    4,910 Views
    9 Pages

    Polyphasic Characterisation of Cedecea colo sp. nov., a New Enteric Bacterium Isolated from the Koala Hindgut

    • Jarryd M. Boath,
    • Sudip Dakhal,
    • Thi Thu Hao Van,
    • Robert J. Moore,
    • Chaitali Dekiwadia and
    • Ian G. Macreadie

    The Cedecea genus is comprised of six rarely isolated species within the Enterobacteriaceae family. Representatives are Gram-negative motile bacilli, and are typically oxidase-negative, lipase-positive and resistant to colistin and cephalothin. In th...

    • Article
    • Open Access
    30 Citations
    4,391 Views
    15 Pages

    Calonectria pseudonaviculata (Cps) poses an increasing threat to boxwood, a major nursery crop and iconic landscape plant worldwide. Here, we report on a potent biocontrol agent that produces small sage green (SSG) colonies on potato dextrose agar. S...

    • Article
    • Open Access
    29 Citations
    4,951 Views
    17 Pages

    Pollution Gradients Altered the Bacterial Community Composition and Stochastic Process of Rural Polluted Ponds

    • Xin Tai,
    • Rui Li,
    • Bao Zhang,
    • Hao Yu,
    • Xiao Kong,
    • Zhihui Bai,
    • Ye Deng,
    • Lan Jia and
    • Decai Jin

    Understanding the effects of pollution on ecological communities and the underlying mechanisms that drive them will helpful for selecting a method to mediate polluted ecosystems. Quantifying the relative importance of deterministic and stochastic pro...

    • Article
    • Open Access
    11 Citations
    5,884 Views
    17 Pages

    Reconstructing and visualizing phylogenetic relationships among living organisms is a fundamental challenge because not all organisms share the same genes. As a result, the first phylogenetic visualizations employed a single gene, e.g., rRNA genes, s...

    • Article
    • Open Access
    29 Citations
    4,383 Views
    16 Pages

    Pine wilt disease (PWD) caused by the nematode Bursaphelenchus xylophilus is a devastating disease in conifer forests in Eurasia. However, information on the effect of PWD on the host microbial community is limited. In this study, the bacterial commu...

    • Review
    • Open Access
    351 Citations
    54,605 Views
    28 Pages

    The human oral cavity is home to an abundant and diverse microbial community (i.e., the oral microbiome), whose composition and roles in health and disease have been the focus of intense research in recent years. Thanks to developments in sequencing-...

    • Article
    • Open Access
    32 Citations
    6,085 Views
    17 Pages

    Daily Intake of Paraprobiotic Lactobacillus amylovorus CP1563 Improves Pre-Obese Conditions and Affects the Gut Microbial Community in Healthy Pre-Obese Subjects: A Double-Blind, Randomized, Placebo-Controlled Study

    • Tomonori Sugawara,
    • Daisuke Sawada,
    • Sae Yanagihara,
    • Yumeko Aoki,
    • Isao Takehara,
    • Hirosuke Sugahara,
    • Tatsuhiko Hirota,
    • Yasunori Nakamura and
    • Susumu Ishikawa

    Despite the fact that gut microbiota is closely associated with obesity, few studies have focused on the influences of paraprobiotics as food ingredients on both obesity prevention and the gut microbial community. In this study, we evaluated the effe...

    • Opinion
    • Open Access
    60 Citations
    6,321 Views
    9 Pages

    Current social and environmental trends explain the rising popularity of artisanal fermented foods and beverages. In contrast with their marketing success, several studies underline a lack of regulations necessary to claim differences occurred from t...

    • Review
    • Open Access
    57 Citations
    10,553 Views
    29 Pages

    Pathogenicity and Virulence Factors of Fusarium graminearum Including Factors Discovered Using Next Generation Sequencing Technologies and Proteomics

    • Molemi E. Rauwane,
    • Udoka V. Ogugua,
    • Chimdi M. Kalu,
    • Lesiba K. Ledwaba,
    • Adugna A. Woldesemayat and
    • Khayalethu Ntushelo

    Fusarium graminearum is a devasting mycotoxin-producing pathogen of grain crops. F. graminearum has been extensively studied to understand its pathogenicity and virulence factors. These studies gained momentum with the advent of next-generation seque...

    • Review
    • Open Access
    123 Citations
    14,310 Views
    21 Pages

    Lactic acid bacteria (LAB) have a long history of use in the food industry. Some species are part of the normal human microbiota and have beneficial properties for human health. Their long-standing use and considerable biotechnological potential have...

    • Article
    • Open Access
    10 Citations
    4,440 Views
    18 Pages

    The emergence of drug resistance to Candida albicans is problematic in the clinical setting. Therefore, developing new antifungal drugs is in high demand. Our previous work indicated that the antimicrobial peptide P-113Tri exhibited higher antifungal...

    • Article
    • Open Access
    5 Citations
    5,193 Views
    7 Pages

    A Rare Glimpse into the Past of the Anthrax Pathogen Bacillus anthracis

    • Peter Braun,
    • Mandy Knüpfer,
    • Markus Antwerpen,
    • Dagmar Triebel and
    • Gregor Grass

    The bacterium Bacillus anthracis is the causative agent of the zoonotic disease anthrax. While genomics of extant B. anthracis isolates established in-depth phylogenomic relationships, there is scarce information on the historic genomics of the patho...

    • Article
    • Open Access
    32 Citations
    5,781 Views
    17 Pages

    The polyketide synthase (PKS) cluster genes are supposed to synthesize polyunsaturated fatty acids (PUFAs) in S. limacinum. In this study, two enyolreductase (ER) genes located on PKS cluster were knocked out through homologous recombination to explo...

    • Communication
    • Open Access
    10 Citations
    3,392 Views
    11 Pages

    Preliminary Survey of Alternaria Toxins Reduction during Fermentation of Whole Wheat Dough

    • Elizabet Janić Hajnal,
    • Lato Pezo,
    • Dejan Orčić,
    • Ljubiša Šarić,
    • Dragana Plavšić,
    • Jovana Kos and
    • Jasna Mastilović

    The aim of this study was to investigate the fate of the most common Alternaria toxins found in wheat—tenuazonic acid (TeA), alternariol (AOH), and alternariol monomethyl ether (AME) during sourdough processing. For this purpose, spiked whole w...

    • Article
    • Open Access
    33 Citations
    5,828 Views
    19 Pages

    Identification of Species and Subspecies of Lactic Acid Bacteria Present in Spanish Cheeses Type “Torta” by MALDI-TOF MS and pheS gene Analyses

    • Fernando Sánchez-Juanes,
    • Vanessa Teixeira-Martín,
    • José Manuel González-Buitrago,
    • Encarna Velázquez and
    • José David Flores-Félix

    Several artisanal cheeses are elaborated in European countries, being commonly curdled with rennets of animal origin. However, in some Spanish regions some cheeses of type “Torta” are elaborated using Cynara cardunculus L. rennets. Two of...

    • Article
    • Open Access
    75 Citations
    7,234 Views
    19 Pages

    In this study, five cyanobacteria strains (Alkalinema aff. pantanalense LEGE15481, Cyanobium gracile LEGE12431, Nodosilinea (Leptolyngbya) antarctica LEGE13457, Cuspidothrix issatschenkoi LEGE03282 and Leptolyngbya-like sp. LEGE13412) from the Blue B...

    • Article
    • Open Access
    28 Citations
    5,333 Views
    22 Pages

    pH is a central environmental factor influencing CH4 production from organic substrates, as every member of the complex microbial community has specific pH requirements. Here, we show how varying pH conditions (5.0–8.5, phosphate buffered) and...

    • Article
    • Open Access
    53 Citations
    6,622 Views
    12 Pages

    Colistin-Resistant Acinetobacter Baumannii Bacteremia: A Serious Threat for Critically Ill Patients

    • Georgios Papathanakos,
    • Ioannis Andrianopoulos,
    • Athanasios Papathanasiou,
    • Efthalia Priavali,
    • Despoina Koulenti and
    • Vasilios Koulouras

    The prevalence of acinetobacter baumannii (AB) as a cause of hospital infections has been rising. Unfortunately, emerging colistin resistance limits therapeutic options and affects the outcome. The aim of the study was to confirm our clinically-drive...

    • Article
    • Open Access
    23 Citations
    5,645 Views
    11 Pages

    Human Cytomegalovirus (HCMV) Reactivation in the Mammary Gland Induces a Proinflammatory Cytokine Shift in Breast Milk

    • Tabea Rabe,
    • Katrin Lazar,
    • Christoffer Cambronero,
    • Rangmar Goelz and
    • Klaus Hamprecht

    A locally restricted human cytomegalovirus (HCMV) reactivation in the mammary gland commonly occurs in nearly every IgG-seropositive breastfeeding mother. This unique phenomenon can therefore be used to study the reactivation process in an immunocomp...

    • Article
    • Open Access
    48 Citations
    5,589 Views
    21 Pages

    Over a two-year period, Mannheimia haemolytica (MH; n = 113), Pasteurella multocida (PM; n = 47), Histophilus somni (HS; n = 41) and Mycoplasma bovis (MB; n = 227) were isolated from bovine lung tissue at necropsy from cattle raised conventionally (C...

    • Review
    • Open Access
    37 Citations
    13,880 Views
    15 Pages

    Scientific Prospects for Cannabis-Microbiome Research to Ensure Quality and Safety of Products

    • Vladimir Vujanovic,
    • Darren R. Korber,
    • Silva Vujanovic,
    • Josko Vujanovic and
    • Suha Jabaji

    Cannabis legalization has occurred in several countries worldwide. Along with steadily growing research in Cannabis healthcare science, there is an increasing interest for scientific-based knowledge in plant microbiology and food science, with work c...

    • Article
    • Open Access
    8 Citations
    4,066 Views
    11 Pages

    An effective bioaugmentation system for oil-contaminated soil under low-temperature conditions was developed with a rotational slurry bioreactor. Mixtures of two Rhodococcus oil-degraders, strain A and C, which are officially permitted to be used in...

    • Article
    • Open Access
    43 Citations
    5,528 Views
    18 Pages

    Construction of a Tetracycline Degrading Bacterial Consortium and Its Application Evaluation in Laboratory-Scale Soil Remediation

    • Xueling Wu,
    • Yichao Gu,
    • Xiaoyan Wu,
    • Xiangyu Zhou,
    • Han Zhou,
    • Charles Amanze,
    • Li Shen and
    • Weimin Zeng

    As an environmental pollutant, tetracycline (TC) can persist in the soil for years and damage the ecosystem. So far, many methods have been developed to handle the TC contamination. Microbial remediation, which involves the use of microbes to biodegr...

    • Article
    • Open Access
    40 Citations
    5,481 Views
    14 Pages

    Discovery of Two Brominated Oxindole Alkaloids as Staphylococcal DNA Gyrase and Pyruvate Kinase Inhibitors via Inverse Virtual Screening

    • Ahmed M. Sayed,
    • Hani A. Alhadrami,
    • Seham S. El-Hawary,
    • Rabab Mohammed,
    • Hossam M. Hassan,
    • Mostafa E. Rateb,
    • Usama Ramadan Abdelmohsen and
    • Walid Bakeer

    In the present study, a small marine-derived natural products library was assessed for antibacterial potential. Among 36 isolated compounds, a number of bis-indole derivatives exhibited growth-inhibitory activity towards Gram-positive strains (Bacill...

    • Article
    • Open Access
    11 Citations
    4,658 Views
    14 Pages

    Proteomic and Transcriptional Profiles of Human Stem Cell-Derived β Cells Following Enteroviral Challenge

    • Julius O. Nyalwidhe,
    • Agata Jurczyk,
    • Basanthi Satish,
    • Sambra Redick,
    • Natasha Qaisar,
    • Melanie I. Trombly,
    • Pranitha Vangala,
    • Riccardo Racicot,
    • Rita Bortell and
    • Jennifer P. Wang
    • + 4 authors

    Enteroviral infections are implicated in islet autoimmunity and type 1 diabetes (T1D) pathogenesis. Significant β-cell stress and damage occur with viral infection, leading to cells that are dysfunctional and vulnerable to destruction. Human ste...

    • Article
    • Open Access
    9 Citations
    3,876 Views
    10 Pages

    Occurrence, Diversity of Listeria spp. Isolates from Food and Food-Contact Surfaces and the Presence of Virulence Genes

    • Franca Rossi,
    • Carmela Amadoro,
    • Daniele Conficoni,
    • Valerio Giaccone and
    • Giampaolo Colavita

    This study evaluates the hazards posed by foodborne bacteria of the Listeria genus by analyzing the occurrence, diversity and virulence of Listeria spp.in food and food-manufacturing plants. Seventy-five isolates obtained from the routine analysis of...

    • Article
    • Open Access
    13 Citations
    4,675 Views
    16 Pages

    DNA Methylation Changes Induced by Cold in Psychrophilic and Psychrotolerant Naganishia Yeast Species

    • Benedetta Turchetti,
    • Gianpiero Marconi,
    • Ciro Sannino,
    • Pietro Buzzini and
    • Emidio Albertini

    The involvement of DNA methylation in the response to cold stress of two different yeast species (Naganishia antarctica, psychrophilic, and Naganishia albida, psychrotolerant), exhibiting different temperature aptitudes, has been studied. Consecutive...

    • Review
    • Open Access
    45 Citations
    4,999 Views
    12 Pages

    Growing resistance to antibiotics is one of the biggest threats to human health. One of the possibilities to overcome this resistance is to use and develop alternative molecules such as antimicrobial peptides (AMPs). However, an increasing number of...

    • Article
    • Open Access
    116 Citations
    7,667 Views
    15 Pages

    An eight-week feeding trial was conducted to evaluate the effects of different dietary probiotic supplements in juvenile whiteleg shrimp, Litopenaeus vannamei. A basal control diet without probiotics (CON), and five other diets by supplementing Bacil...

    • Article
    • Open Access
    27 Citations
    6,333 Views
    13 Pages

    Development of a Lyophilization Process for Campylobacter Bacteriophage Storage and Transport

    • Lu Liang,
    • Nicholas B. Carrigy,
    • Samuel Kariuki,
    • Peter Muturi,
    • Robert Onsare,
    • Tobi Nagel,
    • Reinhard Vehring,
    • Phillippa L. Connerton and
    • Ian F. Connerton

    Bacteriophages are a sustainable alternative to control pathogenic bacteria in the post-antibiotic era. Despite promising reports, there are still obstacles to phage use, notably titer stability and transport-associated expenses for applications in f...

    • Article
    • Open Access
    23 Citations
    5,625 Views
    22 Pages

    Adaptation to Photooxidative Stress: Common and Special Strategies of the Alphaproteobacteria Rhodobacter sphaeroides and Rhodobacter capsulatus

    • Mathieu K. Licht,
    • Aaron M. Nuss,
    • Marcel Volk,
    • Anne Konzer,
    • Michael Beckstette,
    • Bork A. Berghoff and
    • Gabriele Klug

    Photosynthetic bacteria have to deal with the risk of photooxidative stress that occurs in presence of light and oxygen due to the photosensitizing activity of (bacterio-) chlorophylls. Facultative phototrophs of the genus Rhodobacter adapt the forma...

    • Article
    • Open Access
    30 Citations
    4,893 Views
    13 Pages

    The nonylphenol-degrading bacterium Sphingomonas sp. strain NP5 has a very unique monooxygenase that can attack a wide range of 4-alkylphenols with a branched side chain. Due to the structural similarity, it can also attack bisphenolic compounds, whi...

    • Article
    • Open Access
    4 Citations
    3,874 Views
    17 Pages

    The Effect of Posaconazole, Itraconazole and Voriconazole in the Culture Medium on Aspergillus fumigatus Triazole Resistance

    • Martyna Mroczyńska,
    • Ewelina Kurzyk,
    • Magdalena Śliwka-Kaszyńska,
    • Urszula Nawrot,
    • Marta Adamik and
    • Anna Brillowska-Dąbrowska

    Triazoles are the only compounds used as antibiotics in both medicine and agriculture. The presence of triazoles in the environment can contribute to the acquisition of azole resistance among isolates of Aspergillus fumigatus. The objective of this s...

    • Erratum
    • Open Access
    1 Citations
    1,976 Views
    1 Page
    • Meeting Report
    • Open Access
    3,222 Views
    18 Pages

    International Conference and Expo on Microbiology (Microbiology 2019) organized by Coalesce Research Group was held on November 18–19, 2019 at Hotel Novotel Barcelona Sant Joan Despi, Barcelona, Spain. The conference highlighted the theme, &ldq...

    • Review
    • Open Access
    44 Citations
    16,713 Views
    13 Pages

    Anti-Contamination Strategies for Yeast Fermentations

    • Seung-Oh Seo,
    • Sung-Kyun Park,
    • Suk-Chae Jung,
    • Choong-Min Ryu and
    • Jun-Seob Kim

    Yeasts are very useful microorganisms that are used in many industrial fermentation processes such as food and alcohol production. Microbial contamination of such processes is inevitable, since most of the fermentation substrates are not sterile. Con...

    • Article
    • Open Access
    15 Citations
    4,429 Views
    22 Pages

    USA300 is a predominant community-associated methicillin-resistant Staphylococcus aureus strain which carries an arginine catabolic mobile element (ACME). ACME contains potential virulence factors including an arginine deiminase (arc) pathway and an...

    • Review
    • Open Access
    57 Citations
    39,510 Views
    16 Pages

    Measles: An Overview of a Re-Emerging Disease in Children and Immunocompromised Patients

    • Andrea Misin,
    • Roberta Maria Antonello,
    • Stefano Di Bella,
    • Giuseppina Campisciano,
    • Nunzia Zanotta,
    • Daniele Roberto Giacobbe,
    • Manola Comar and
    • Roberto Luzzati

    Despite the availability of a safe and effective vaccine, in 2018, around 350,000 measles cases were reported worldwide, which resulted in an estimate of 142,300 deaths from measles. Additionally, in 2017, global measles cases spiked, causing the dea...

    • Article
    • Open Access
    27 Citations
    5,254 Views
    14 Pages

    Diverse Microbial Community Profiles of Propionate-Degrading Cultures Derived from Different Sludge Sources of Anaerobic Wastewater Treatment Plants

    • Pantakan Puengrang,
    • Benjaphon Suraraksa,
    • Peerada Prommeenate,
    • Nimaradee Boonapatcharoen,
    • Supapon Cheevadhanarak,
    • Morakot Tanticharoen and
    • Kanthida Kusonmano

    Anaerobic digestion (AD) has been used for wastewater treatment and production of renewable energy or biogas. Propionate accumulation is one of the important problems leading to an unstable system and low methane production. Revealing propionate-degr...

    • Article
    • Open Access
    34 Citations
    5,978 Views
    17 Pages

    Metalaxyl is one of the main fungicides used to control pepper blight caused by Phytophthora capsici. Metalaxyl resistance of P. capsici, caused by the long-term intense use of this fungicide, has become one of the most serious challenges facing pest...

    • Article
    • Open Access
    14 Citations
    6,014 Views
    20 Pages

    Diversity of Bacterial Biosynthetic Genes in Maritime Antarctica

    • Adriana Rego,
    • António G. G. Sousa,
    • João P. Santos,
    • Francisco Pascoal,
    • João Canário,
    • Pedro N. Leão and
    • Catarina Magalhães

    Bacterial natural products (NPs) are still a major source of new drug leads. Polyketides (PKs) and non-ribosomal peptides (NRP) are two pharmaceutically important families of NPs and recent studies have revealed Antarctica to harbor endemic polyketid...

    • Article
    • Open Access
    57 Citations
    7,291 Views
    20 Pages

    Organic fertilizer is a major carrier that stores and transmits antibiotic resistance genes (ARGs). In the environment, due to the application of organic fertilizers in agriculture, the increasing diversity and abundance of ARGs poses a potential thr...

    • Review
    • Open Access
    98 Citations
    13,752 Views
    17 Pages

    Antimicrobial resistance is a major concern. Epidemiological studies have demonstrated direct relationships between antibiotic consumption and emergence/dissemination of resistant strains. Within the last decade, authors confounded spectrum activity...

    • Review
    • Open Access
    14 Citations
    5,774 Views
    13 Pages

    In Vitro Zika Virus Infection of Human Neural Progenitor Cells: Meta-Analysis of RNA-Seq Assays

    • Rossella Gratton,
    • Paola Maura Tricarico,
    • Almerinda Agrelli,
    • Heverton Valentim Colaço da Silva,
    • Lucas Coêlho Bernardo,
    • Sergio Crovella,
    • Antonio Victor Campos Coelho,
    • Ronald Rodrigues de Moura and
    • Lucas André Cavalcanti Brandão

    The Zika virus (ZIKV) is an emergent arthropod-borne virus (arbovirus) responsible for congenital Zika syndrome (CZS) and a range of other congenital malformations. Evidence shows that ZIKV infects human neural progenitor cells (hNPCs) in the fetal b...

    • Article
    • Open Access
    13 Citations
    3,971 Views
    14 Pages

    Regulatory Patterns of Crp on Monensin Biosynthesis in Streptomyces cinnamonensis

    • Chun-Yan Lin,
    • Yue Zhang,
    • Ji-Hua Wu,
    • Rong-Hui Xie,
    • Jianjun Qiao and
    • Guang-Rong Zhao

    Monensin, produced by Streptomyces cinnamonensis, is a polyether ionophore antibiotic widely used as a coccidiostat and a growth-promoting agent in agricultural industry. In this study, cyclic AMP receptor protein (Crp), the global transcription fact...

    • Communication
    • Open Access
    18 Citations
    4,066 Views
    9 Pages

    As a novel and safe sanitizer, polyhexamethylene guanidine hydrochloride (PHMG) has been used to inhibit the spoilage of agricultural products caused by fungi. However, little is known about its antibacterial effects on vegetables. In this study, we...

    • Review
    • Open Access
    82 Citations
    9,292 Views
    20 Pages

    Functional and Structural Roles of the Major Facilitator Superfamily Bacterial Multidrug Efflux Pumps

    • Sanath Kumar,
    • Manjusha Lekshmi,
    • Ammini Parvathi,
    • Manisha Ojha,
    • Nicholas Wenzel and
    • Manuel F. Varela

    Pathogenic microorganisms that are multidrug-resistant can pose severe clinical and public health concerns. In particular, bacterial multidrug efflux transporters of the major facilitator superfamily constitute a notable group of drug resistance mech...

    • Article
    • Open Access
    19 Citations
    4,009 Views
    17 Pages

    Epstein-Barr virus (EBV) infects more than 90% of the global population and is associated with a variety of tumors including nasopharyngeal carcinoma, Hodgkin lymphoma, natural killer/T lymphoma, and gastric carcinoma. In EBV-associated gastric cance...

    • Article
    • Open Access
    22 Citations
    5,693 Views
    19 Pages

    Managed and Unmanaged Pinus sylvestris Forest Stands Harbour Similar Diversity and Composition of the Phyllosphere and Soil Fungi

    • Jūratė Lynikienė,
    • Diana Marčiulynienė,
    • Adas Marčiulynas,
    • Artūras Gedminas,
    • Miglė Vaičiukynė and
    • Audrius Menkis

    The aim was to assess fungal communities associated with living needles and soil of Pinus sylvestris in managed and unmanaged forest stands to get a better understanding of whether and how different intensities of forest management affects fungal div...

    • Article
    • Open Access
    35 Citations
    4,794 Views
    14 Pages

    Characterization of Ocular Clinical Isolates of Pseudomonas aeruginosa from Non-Contact Lens Related Keratitis Patients from South India

    • Alpana Dave,
    • Apurwa Samarth,
    • Roshni Karolia,
    • Savitri Sharma,
    • Esther Karunakaran,
    • Lynda Partridge,
    • Sheila MacNeil,
    • Peter N. Monk,
    • Prashant Garg and
    • Sanhita Roy

    P. aeruginosa is the most common Gram-negative organism causing bacterial keratitis. Pseudomonas utilizes various virulence mechanisms to adhere and colonize in the host tissue. In the present study, we examined virulence factors associated with thir...

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    Microorganisms - ISSN 2076-2607