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Special Issue "Cytomegalovirus: Biology and Infection"
Deadline for manuscript submissions: 31 March 2020.
Interests: viral infections; innate immunity; viral restriction factors; inflammation; antiviral drug discovery; post-translational modifications; viral genome variability; viral effects on metabolism
Human cytomegalovirus (HCMV) is a β-herpesvirus with the largest dsDNA genome of all known human viruses (~235,000 bp). Although initial HCMV infection is usually associated with mild symptoms in healthy individuals, it can cause severe and sometimes fatal diseases in immunocompromised individuals (e.g., transplant recipients and AIDS patients) and neonates upon congenital or acquired infection. Even though a vaccine is not yet available, different compounds are currently licensed to treat established HCMV infections. However, despite encouraging clinical outcomes, their use has been hampered by major associated adverse effects and the emergence of antiviral-resistant HCMV strains, especially in immunocompromised patients. One aspect of HCMV biology that has recently emerged is the high level of intra-host genetic variability, comparable to that of RNA viruses. Throughout evolution, this variability helped the virus to acquire a sophisticated repertoire of immune escape mechanisms, enabling infected cells to subvert immune recognition and thereby maintain the progression of infection.
The aim of this Special Issue is to give an overall picture of all aspects of HCMV biology, with particular emphasis on virus–host interaction. For this purpose, we welcome the submission of research articles, review articles, and short communications related to the various aspects of HCMV infection: virus–host interactions (pathogenesis and related diseases, immunity, tropism, and metabolism), therapy and prevention, and virus biology (replication, genome variability, and evolution).
We believe that this Special Issue will give an updated insight into the exciting field of HCMV biology and hope that it will inspire new research activities.
As Guest Editor of this Special Issue, I look forward to reviewing your submissions and, together, defining the present state of the science.
Dr. Valentina Dell’Oste
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- human cytomegalovirus (HCMV)
- pathogenesis and related diseases
- innate/adaptative immunity
- genome variability/evolution
- antiviral treatments/vaccines