Special Issue "Cytomegalovirus: Biology and Infection"

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 31 March 2020.

Special Issue Editor

Dr. Valentina Dell'Oste
E-Mail Website1 Website2
Guest Editor
Laboratory of Pathogenesis of Viral Infections, Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy
Interests: viral infections; innate immunity; viral restriction factors; inflammation; antiviral drug discovery; post-translational modifications; viral genome variability; viral effects on metabolism

Special Issue Information

Dear Colleagues,

Human cytomegalovirus (HCMV) is a β-herpesvirus with the largest dsDNA genome of all known human viruses (~235,000 bp). Although initial HCMV infection is usually associated with mild symptoms in healthy individuals, it can cause severe and sometimes fatal diseases in immunocompromised individuals (e.g., transplant recipients and AIDS patients) and neonates upon congenital or acquired infection. Even though a vaccine is not yet available, different compounds are currently licensed to treat established HCMV infections. However, despite encouraging clinical outcomes, their use has been hampered by major associated adverse effects and the emergence of antiviral-resistant HCMV strains, especially in immunocompromised patients. One aspect of HCMV biology that has recently emerged is the high level of intra-host genetic variability, comparable to that of RNA viruses. Throughout evolution, this variability helped the virus to acquire a sophisticated repertoire of immune escape mechanisms, enabling infected cells to subvert immune recognition and thereby maintain the progression of infection.

The aim of this Special Issue is to give an overall picture of all aspects of HCMV biology, with particular emphasis on virus–host interaction. For this purpose, we welcome the submission of research articles, review articles, and short communications related to the various aspects of HCMV infection: virus–host interactions (pathogenesis and related diseases, immunity, tropism, and metabolism), therapy and prevention, and virus biology (replication, genome variability, and evolution).  

We believe that this Special Issue will give an updated insight into the exciting field of HCMV biology and hope that it will inspire new research activities.

As Guest Editor of this Special Issue, I look forward to reviewing your submissions and, together, defining the present state of the science.

Dr. Valentina Dell’Oste
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • human cytomegalovirus (HCMV)
  • pathogenesis and related diseases
  • innate/adaptative immunity
  • genome variability/evolution
  • antiviral treatments/vaccines
  • tropism
  • metabolism

Published Papers (1 paper)

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Research

Open AccessArticle
NK Cells from RAG- or DCLRE1C-Deficient Patients Inhibit HCMV
Microorganisms 2019, 7(11), 546; https://doi.org/10.3390/microorganisms7110546 - 10 Nov 2019
Abstract
The recombination-activating genes (RAGs) and the DNA cross-link repair 1C gene (DCLRE1C) encode the enzymes RAG1, RAG2 and Artemis. They are critical components of the V(D)J recombination machinery. V(D)J recombination is well known as a prerequisite for the development and antigen diversity of [...] Read more.
The recombination-activating genes (RAGs) and the DNA cross-link repair 1C gene (DCLRE1C) encode the enzymes RAG1, RAG2 and Artemis. They are critical components of the V(D)J recombination machinery. V(D)J recombination is well known as a prerequisite for the development and antigen diversity of T and B cells. New findings suggested that RAG deficiency impacts the cellular fitness and function of murine NK cells. It is not known whether NK cells from severe combined immunodeficiency (SCID) patients with defective RAGs or DCLRE1C (RAGs/DCLRE1C-NK) are active against virus infections. Here, we evaluated the anti-HCMV activity of RAGs/DCLRE1C-NK cells. NK cells from six SCID patients were functional in inhibiting HCMV transmission between cells in vitro. We also investigated the expansion of HCMV-induced NK cell subset in the RAG- or DCLRE1C-deficient patients. A dynamic expansion of NKG2C+ NK cells in one RAG-2-deficient patient was observed post HCMV acute infection. Our study firstly reveals the antiviral activity of human RAGs/ DCLRE1C-NK cells. Full article
(This article belongs to the Special Issue Cytomegalovirus: Biology and Infection)
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