Special Issue "Natural Antimicrobial Compounds"

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".

Deadline for manuscript submissions: 31 August 2020.

Special Issue Editors

Dr. Andreana Marino
E-Mail Website
Guest Editor
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy
Interests: antimicrobials; biofilm; plant extracts; natural antimicrobial compounds; ocular infection
Dr. Giovanna Simonetti
E-Mail Website
Guest Editor
Department of Environmental Biology, “Sapienza” University of Rome, Italy
Interests: antimicrobials; molds; yeasts; antimicrobial resistance; biofilm
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Special Issue Information

Dear Colleagues,

In recent years, the emergence of microbial and viral infections associated with multidrug-resistant and biofilm-forming microorganisms has become one of the biggest challenges to fight in the medical field. Moreover, of particular concern is that some preservative-resistant bacterial strains isolated from cosmetic products show a degree of cross-resistance with antibiotics.

In addition to resistance, with the growing immunocompromised population due to organ transplant, chemotherapy, and AIDS, the frequency of microbial and viral infections has sharply increased. All the above-mentioned situations together with a limited arsenal of antimicrobial and antiviral drugs and agents encourage the development of new therapeutic approaches to combat microbial and viral infections. Various strategies have been suggested, and one of these involves natural products with antimicrobial properties or that have the ability to enhance the activity of an antibiotic in combination with them. Novel or long-known natural products alone or combined with nanoformulations have consistently offered good prospects for the development and discovery of therapeutics or preservatives over the past decades, and still play an important role in innovation in pharmaceutical and other industries. This Special Issue aims to highlight the latest advances and developments associated with nanotechnology and therapeutic benefits related to the use of natural products and/or isolated compounds alone or in association with conventional drugs for microbial infections.

Both in vitro and in vivo studies are encouraged. A detailed chemical analysis of the natural compounds should be presented, as well as their toxicity.

We invite authors who are leading experts in this field to contribute original articles that are not yet published or that are not currently under review by other journals. Review articles which describe the current state of the research on this topic are also welcome. The publication of articles in this Special Issue will provide a forum for researchers to share their recent findings and offer exposure of the published articles to the scientific community, and we will work to promote, integrate, and disseminate them. We hope that this Special Issue will advance knowledge and stimulate new collaborations and new research directions.

We will consider works on topics including but not limited to:

  • Natural products and/or isolated compounds active against microorganisms and viruses.
  • Natural products and/or isolated compounds active against microbial biofilms.
  • Chemical characterization of antimicrobial natural products and/or isolated compounds active against microorganisms.
  • Toxicity studies in vitro and/or in vivo.
  • Natural products and/or isolated compounds active against microorganisms in association with conventional drugs.
  • Elucidation of the mechanism of action of natural products and/or isolated compounds active against microorganisms alone or in combination with conventional drugs.
  • Novel nanoformulations for the delivery of natural products and/or isolated compounds active against microorganisms.

Dr. Andreana Marino
Dr. Giovanna Simonetti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial natural products
  • natural isolated compounds active against microorganisms
  • biofilms
  • antimicrobial natural products in combination with drugs or preservatives
  • chemical characterization
  • toxicity
  • mechanism of action
  • nanoformulations

Published Papers (1 paper)

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Research

Open AccessArticle
Reuterin Demonstrates Potent Antimicrobial Activity Against a Broad Panel of Human and Poultry Meat Campylobacter spp. Isolates
Microorganisms 2020, 8(1), 78; https://doi.org/10.3390/microorganisms8010078 - 06 Jan 2020
Abstract
Reuterin is a broad-spectrum antimicrobial system produced by specific strains of Lactobacillus reuteri during anaerobic metabolism of glycerol. Acrolein is the main component responsible for its antimicrobial activity. Here, the sensitivity of Campylobacter jejuni (n = 51) and Campylobacter coli (n [...] Read more.
Reuterin is a broad-spectrum antimicrobial system produced by specific strains of Lactobacillus reuteri during anaerobic metabolism of glycerol. Acrolein is the main component responsible for its antimicrobial activity. Here, the sensitivity of Campylobacter jejuni (n = 51) and Campylobacter coli (n = 20) isolates from chicken meat and human stool samples to reuterin was investigated. The minimum inhibitory concentration (MIC) of C. jejuni and C. coli strains was measured between 1.5 and 3.0 µM of acrolein, below the MIC of the sensitive indicator strain Escherichia coli K12 (16.5 µM acrolein). The interaction of C. jejuni N16-1419 and the reuterin-producing L. reuteri PTA5_F13 was studied during 24 h co-cultures with or without glycerol. A high C. jejuni growth was observed in cultures without glycerol. In contrast, C. jejuni growth decreased from 7.3 ± 0.1 log CFU/mL to below detection limit (1 log CFU/mL) during co-cultures added with 28 mM glycerol. This bactericidal effect could be attributed to in situ reuterin production. The low MIC observed and the high sensitivity towards in situ produced reuterin suggests L. reuteri combined with glycerol, as a possible intervention option to reduce Campylobacter in the food chain. Full article
(This article belongs to the Special Issue Natural Antimicrobial Compounds)
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