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Microorganisms, Volume 7, Issue 11

2019 November - 105 articles

Cover Story: Environmental scanning electron microscopy (ESEM-LFD) image representing bifidobacterial cells (violet). Bifidobacteria were held on an aluminum stub with a silicon wafer (gray). The picture was performed under the supervision of Prof. Marco Ventura and Prof. Francesca Turroni (Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy) by Prof. Marta Marmiroli (Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy) and edited by Dr. Lugli Gabriele Andrea (Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy).View this paper.
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Articles (105)

  • Article
  • Open Access
39 Citations
6,954 Views
18 Pages

Photosynthesis is a key process for the establishment and maintenance of life on earth, and it is manifested in several major lineages of the prokaryote tree of life. The evolution of photosynthesis in anoxygenic photosynthetic bacteria is of major i...

  • Article
  • Open Access
12 Citations
6,143 Views
18 Pages

Life in salt pans with varying chemical compositions require special adaptation strategies at both the physiological and molecular level. The Marakkanam salt pan in South India is characterized with a high fluctuation in salinity (19–490 ppt),...

  • Article
  • Open Access
42 Citations
6,302 Views
28 Pages

Study of Metabolic Adaptation of Red Yeasts to Waste Animal Fat Substrate

  • Martin Szotkowski,
  • Dana Byrtusova,
  • Andrea Haronikova,
  • Marie Vysoka,
  • Marek Rapta,
  • Volha Shapaval and
  • Ivana Marova

Carotenogenic yeasts are non-conventional oleaginous microorganisms capable of utilizing various waste substrates. In this work, four red yeast strains (Rhodotorula, Cystofilobasidium, and Sporobolomyces sp.) were cultivated in media containing crude...

  • Article
  • Open Access
15 Citations
5,120 Views
16 Pages

Hyper-Aerotolerant Campylobacter coli from Duck Sources and Its Potential Threat to Public Health: Virulence, Antimicrobial Resistance, and Genetic Relatedness

  • Jae-Ho Guk,
  • Junhyung Kim,
  • Hyokeun Song,
  • Jinshil Kim,
  • Jae-Uk An,
  • Jonghyun Kim,
  • Sangryeol Ryu,
  • Byeonghwa Jeon and
  • Seongbeom Cho

Campylobacter, a common foodborne human pathogen, is considered sensitive to oxygen. Recently, aerotolerant (AT) Campylobacter jejuni with the ability to survive under aerobic stress has been reported. Here, we investigated the prevalence of hyper-ae...

  • Article
  • Open Access
18 Citations
7,136 Views
14 Pages

Staphylococcus arlettae Genomics: Novel Insights on Candidate Antibiotic Resistance and Virulence Genes in an Emerging Opportunistic Pathogen

  • Anna Lavecchia,
  • Matteo Chiara,
  • Caterina De Virgilio,
  • Caterina Manzari,
  • Rosa Monno,
  • Armando De Carlo,
  • Carlo Pazzani,
  • David Horner,
  • Graziano Pesole and
  • Antonio Placido

Coagulase Negative Staphylococci (CoNS) are becoming increasingly recognized as an important cause of human and animal infections. Notwithstanding their clinical relevance, annotation of genes potentially involved in pathogenicity and/or antibiotic r...

  • Review
  • Open Access
244 Citations
13,581 Views
29 Pages

Surfactants are a broad category of tensio-active biomolecules with multifunctional properties applications in diverse industrial sectors and processes. Surfactants are produced synthetically and biologically. The biologically derived surfactants (bi...

  • Article
  • Open Access
9 Citations
4,120 Views
25 Pages

Structural Insights into Escherichia coli Shiga Toxin (Stx) Glycosphingolipid Receptors of Porcine Renal Epithelial Cells and Inhibition of Stx-Mediated Cellular Injury Using Neoglycolipid-Spiked Glycovesicles

  • Johanna Detzner,
  • Caroline Gloerfeld,
  • Gottfried Pohlentz,
  • Nadine Legros,
  • Hans-Ulrich Humpf,
  • Alexander Mellmann,
  • Helge Karch and
  • Johannes Müthing

Shiga toxin (Stx) producing Escherichia coli (STEC) cause the edema disease in pigs by releasing the swine-pathogenic Stx2e subtype as the key virulence factor. Stx2e targets endothelial cells of animal organs including the kidney harboring the Stx r...

  • Article
  • Open Access
58 Citations
5,031 Views
21 Pages

Mycotoxins in Flanders’ Fields: Occurrence and Correlations with Fusarium Species in Whole-Plant Harvested Maize

  • Jonas Vandicke,
  • Katrien De Visschere,
  • Siska Croubels,
  • Sarah De Saeger,
  • Kris Audenaert and
  • Geert Haesaert

Mycotoxins are well-known contaminants of several food- and feedstuffs, including silage maize for dairy cattle. Climate change and year-to-year variations in climatic conditions may cause a shift in the fungal populations infecting maize, and theref...

  • Article
  • Open Access
10 Citations
5,531 Views
17 Pages

The Type III Accessory Protein HrpE of Xanthomonas oryzae pv. oryzae Surpasses the Secretion Role, and Enhances Plant Resistance and Photosynthesis

  • Taha Majid Mahmood Sheikh,
  • Liyuan Zhang,
  • Muhammad Zubair,
  • Alvina Hanif,
  • Ping Li,
  • Ayaz Farzand,
  • Haider Ali,
  • Muhammad Saqib Bilal,
  • Yiqun Hu and
  • Meixiang Zhang
  • + 3 authors

Many species of plant-pathogenic gram-negative bacteria deploy the type III (T3) secretion system to secrete virulence components, which are mostly characteristic of protein effectors targeting the cytosol of the plant cell following secretion. Xanth...

  • Article
  • Open Access
12 Citations
4,815 Views
16 Pages

Kinematic Locomotion Changes in C57BL/6 Mice Infected with Toxoplasma Strain ME49

  • María de la Luz Galván-Ramírez,
  • Angel Gustavo Salas-Lais,
  • Sergio Horacio Dueñas-Jiménez,
  • Gerardo Mendizabal-Ruiz,
  • Ramón Franco Topete,
  • Sofía Citlalli Berumen-Solís,
  • Laura Roció Rodríguez Pérez and
  • Karina Franco Topete

Chronic infection with the intracellular parasite Toxoplasma gondii produces an accumulation of cysts in the brain and muscle, causing tissue damage. The cysts in the brain motor regions affect some kinematic locomotion parameters in the host. To loc...

  • Article
  • Open Access
24 Citations
4,047 Views
17 Pages

The composition of the bacterial community affects the intestinal health and growth performance of broiler chickens. The main purpose of this study was to explore the effects of flavomycin and colistin sulfate on the resistance to Salmonella typhimur...

  • Article
  • Open Access
10 Citations
3,355 Views
12 Pages

Industrial production of bioethanol from lignocellulosic materials (LCM′s) is reliant on a microorganism being tolerant to the stresses inherent to fermentation. Previous work has highlighted the importance of a cytochrome oxidase chaperone gen...

  • Review
  • Open Access
38 Citations
13,047 Views
22 Pages

Bacteriophages as Potential Tools for Detection and Control of Salmonella spp. in Food Systems

  • Shuai Wei,
  • Ramachandran Chelliah,
  • Momna Rubab,
  • Deog-Hwan Oh,
  • Md Jalal Uddin and
  • Juhee Ahn

The global problem of antibiotic resistance in bacteria is quickly developing in most antibiotics used in hospitals and livestock. Recently, the infections with multi-drug resistant (MDR) bacteria become a major cause of death worldwide. Current anti...

  • Article
  • Open Access
8 Citations
3,699 Views
11 Pages

Identification of A Novel Arsenic Resistance Transposon Nested in A Mercury Resistance Transposon of Bacillus sp. MB24

  • Mei-Fang Chien,
  • Ying-Ning Ho,
  • Hui-Erh Yang,
  • Masaru Narita,
  • Keisuke Miyauchi,
  • Ginro Endo and
  • Chieh-Chen Huang

A novel TnMERI1-like transposon designated as TnMARS1 was identified from mercury resistant Bacilli isolated from Minamata Bay sediment. Two adjacent ars operon-like gene clusters, ars1 and ars2, flanked by a pair of 78-bp inverted repeat sequences,...

  • Article
  • Open Access
8 Citations
4,360 Views
25 Pages

Many cool-season grasses have symbiotic relationships with Epichloë (Ascomycota, Clavicipitaceae) fungal endophytes that inhabit the intercellular spaces of the above-ground parts of the host plants. The presence of the Epichloë endophytes...

  • Article
  • Open Access
32 Citations
5,068 Views
13 Pages

Multiple Lineages of Usutu Virus (Flaviviridae, Flavivirus) in Blackbirds (Turdus merula) and Mosquitoes (Culex pipiens, Cx. modestus) in the Czech Republic (2016–2019)

  • Vaclav Hönig,
  • Martin Palus,
  • Tomas Kaspar,
  • Marta Zemanova,
  • Karolina Majerova,
  • Lada Hofmannova,
  • Petr Papezik,
  • Silvie Sikutova,
  • Frantisek Rettich and
  • Daniel Ruzek
  • + 4 authors

Usutu virus (USUV) is a flavivirus (Flaviviridae: Flavivirus) of an African origin transmitted among its natural hosts (diverse species of birds) by mosquitoes. The virus was introduced multiple times to Europe where it caused mortality of blackbirds...

  • Review
  • Open Access
339 Citations
22,792 Views
18 Pages

Fish immunization has been carried out for over 50 years and is generally accepted as an effective method for preventing a wide range of bacterial and viral diseases. Vaccination efforts contribute to environmental, social, and economic sustainabilit...

  • Article
  • Open Access
4 Citations
4,572 Views
19 Pages

As more microbiological data for indigenous fermented milk (IFM) becomes available, concern about their microbial safety becomes eminent. Nonetheless, these data are highly fragmented, and a tool is required to integrate existing data and to provide...

  • Article
  • Open Access
5 Citations
3,620 Views
9 Pages

Allelopathic interactions mediated by bacteriocins production serve microorganisms in the never-ending battle for resources and living space. Competition between the bacteriocin producer and sensitive populations results in the exclusion of one or th...

  • Article
  • Open Access
5 Citations
3,720 Views
17 Pages

Mapping Epitopes of a Novel Peptidoglycan Cross-Linking Enzyme Cwp22 Recognized by Human Sera Obtained from Patients with Clostridioides difficile Infection and Cord Blood

  • Agnieszka Razim,
  • Katarzyna Pacyga,
  • Gajane Martirosian,
  • Andrzej Szuba,
  • Andrzej Gamian,
  • Andrzej Myc and
  • Sabina Górska

Clostridioides difficile (CD) cause a severe diarrhea which can lead to pseudomembranous colitis and even patient death. CD infection (CDI) is connected mainly with changes in intestinal microbiota as a consequence of antibiotic treatment. The growin...

  • Article
  • Open Access
24 Citations
5,143 Views
22 Pages

Analysis of the Indole Diterpene Gene Cluster for Biosynthesis of the Epoxy-Janthitrems in Epichloë Endophytes

  • Emma J. Ludlow,
  • Simone Vassiliadis,
  • Piyumi N. Ekanayake,
  • Inoka K. Hettiarachchige,
  • Priyanka Reddy,
  • Tim I. Sawbridge,
  • Simone J. Rochfort,
  • German C. Spangenberg and
  • Kathryn M. Guthridge

Epoxy-janthitrems are a class of indole diterpenes with structural similarity to lolitrem B. Two taxa of asexual Epichloë endophytes have been reported to produce epoxy-janthitrems, LpTG-3 (Lolium perenne Taxonomic Group 3; e.g., NEA12) and LpTG...

  • Review
  • Open Access
32 Citations
7,238 Views
34 Pages

Gut Bacteria and their Metabolites: Which One Is the Defendant for Colorectal Cancer?

  • Samira Tarashi,
  • Seyed Davar Siadat,
  • Sara Ahmadi Badi,
  • Mohammadreza Zali,
  • Roberto Biassoni,
  • Mirco Ponzoni and
  • Arfa Moshiri

Colorectal cancer (CRC) is a worldwide health concern which requires efficient therapeutic strategies. The mechanisms underlying CRC remain an essential subject of investigations in the cancer biology field. The evaluation of human microbiota can be...

  • Article
  • Open Access
50 Citations
5,246 Views
14 Pages

Perilla frutescens (L.) Britt., an annual herbaceous plant, has antibacterial, anti-inflammation, and antioxidant properties. To understand the effects of P. frutescens leaf on the ruminal microbial ecology of cattle, Illumina MiSeq 16S rRNA sequenci...

  • Review
  • Open Access
37 Citations
7,865 Views
20 Pages

Asymmetrical flow field-flow fractionation (AF4) separates sample components based on their sizes in the absence of a stationary phase. It is well suited for high molecular weight samples such as virus-sized particles. The AF4 experiment can potentia...

  • Article
  • Open Access
11 Citations
4,008 Views
18 Pages

Prevalence, Distribution, and Phylogeny of Type Two Toxin-Antitoxin Genes Possessed by Cronobacter Species where C. sakazakii Homologs Follow Sequence Type Lineages

  • Samantha Finkelstein,
  • Flavia Negrete,
  • Hyein Jang,
  • Jayanthi Gangiredla,
  • Mark Mammel,
  • Isha R. Patel,
  • Hannah R. Chase,
  • JungHa Woo,
  • YouYoung Lee and
  • Gopal R. Gopinath
  • + 3 authors

Cronobacter species are a group of foodborne pathogenic bacteria that cause both intestinal and systemic human disease in individuals of all age groups. Little is known about the mechanisms that Cronobacter employ to survive and persist in foods and...

  • Article
  • Open Access
48 Citations
7,511 Views
14 Pages

Combined Use of the Ab105-2φΔCI Lytic Mutant Phage and Different Antibiotics in Clinical Isolates of Multi-Resistant Acinetobacter baumannii

  • Lucia Blasco,
  • Anton Ambroa,
  • Maria Lopez,
  • Laura Fernandez-Garcia,
  • Ines Bleriot,
  • Rocio Trastoy,
  • Jose Ramos-Vivas,
  • Tom Coenye,
  • Felipe Fernandez-Cuenca and
  • Maria Tomas
  • + 7 authors

Phage therapy is an abandoned antimicrobial therapy that has been resumed in recent years. In this study, we mutated a lysogenic phage from Acinetobacter baumannii into a lytic phage (Ab105-2phiΔCI) that displayed antimicrobial activity against...

  • Article
  • Open Access
5 Citations
4,715 Views
12 Pages

Sexually Transmitted Infections and Behavioral Determinants of Sexual and Reproductive Health in the Allahabad District (India) Based on Data from the ChlamIndia Study

  • Pierre P. M. Thomas,
  • Jay Yadav,
  • Rajiv Kant,
  • Elena Ambrosino,
  • Smita Srivastava,
  • Gurpreet Batra,
  • Arvind Dayal,
  • Nidhi Masih,
  • Akash Pandey and
  • Servaas A. Morré
  • + 3 authors

Background: Sexually transmitted infections (STIs), like Chlamydia trachomatis and Neisseria gonorrhoeae (CT and NG, respectively) are linked to an important sexual and reproductive health (SRH) burden worldwide. Behavior is an important predictor fo...

  • Article
  • Open Access
16 Citations
5,248 Views
13 Pages

Characteristics of a Colistin-Resistant Escherichia coli ST695 Harboring the Chromosomally-Encoded mcr-1 Gene

  • Zhong Peng,
  • Zizhe Hu,
  • Zugang Li,
  • Xiaosong Li,
  • Chaoying Jia,
  • Xiaoxue Zhang,
  • Bin Wu,
  • Huanchun Chen and
  • Xiangru Wang

Enterobacteriaceae having chromosomally-encoded mcr-1 is rarely reported. In this study, we recovered a chromosomal mcr-1 carrying Escherichia coli, designated HeN100, from the feces of a diarrheal pig in China. Antimicrobial susceptibility testing s...

  • Article
  • Open Access
16 Citations
4,451 Views
15 Pages

Cell-Wall Hydrolases as Antimicrobials against Staphylococcus Species: Focus on Sle1

  • Aurore Vermassen,
  • Régine Talon,
  • Carine Andant,
  • Christian Provot,
  • Mickaël Desvaux and
  • Sabine Leroy

Some staphylococcal species are opportunistic pathogens of humans and/or animals with Staphylococcus epidermidis as one of the most important. It causes a broad spectrum of diseases in humans and animals. This species is able to form biofilms and has...

  • Review
  • Open Access
142 Citations
26,548 Views
19 Pages

The Skin and Gut Microbiome and Its Role in Common Dermatologic Conditions

  • Samantha R. Ellis,
  • Mimi Nguyen,
  • Alexandra R. Vaughn,
  • Manisha Notay,
  • Waqas A. Burney,
  • Simran Sandhu and
  • Raja K. Sivamani

Microorganisms inhabit various areas of the body, including the gut and skin, and are important in maintaining homeostasis. Changes to the normal microflora due to genetic or environmental factors can contribute to the development of various disease...

  • Article
  • Open Access
15 Citations
5,968 Views
15 Pages

Numerous ecological studies on myxobacteria have been conducted, but their true diversity remains largely unknown. To bridge this gap, we implemented a comprehensive survey of diversity and distribution of myxobacteria by using 4997 publicly availabl...

  • Communication
  • Open Access
17 Citations
4,737 Views
7 Pages

Enhanced Production of Fatty Acid Ethyl Ester with Engineered fabHDG Operon in Escherichia coli

  • Ziaur Rahman,
  • Bong Hyun Sung,
  • Javed Nawab,
  • Muhammad Faisal Siddiqui,
  • Abid Ali,
  • Almando Geraldi and
  • Sun Chang Kim

Biodiesel, or fatty acid ethyl ester (FAEE), is an environmentally safe, next-generation biofuel. Conventionally, FAEE is produced by the conversion of oil/fats, obtained from plants, animals, and microorganisms, by transesterification. Recently, met...

  • Article
  • Open Access
11 Citations
5,234 Views
29 Pages

Computational Modelling of Metabolic Burden and Substrate Toxicity in Escherichia coli Carrying a Synthetic Metabolic Pathway

  • Martin Demko,
  • Lukáš Chrást,
  • Pavel Dvořák,
  • Jiří Damborský and
  • David Šafránek

In our previous work, we designed and implemented a synthetic metabolic pathway for 1,2,3-trichloropropane (TCP) biodegradation in Escherichia coli. Significant effects of metabolic burden and toxicity exacerbation were observed on single cell and po...

  • Article
  • Open Access
12 Citations
4,295 Views
19 Pages

Linking Soil Fungal Generality to Tree Richness in Young Subtropical Chinese Forests

  • Christina Weißbecker,
  • Anna Heintz-Buschart,
  • Helge Bruelheide,
  • François Buscot and
  • Tesfaye Wubet

Soil fungi are a highly diverse group of microorganisms that provide many ecosystem services. The mechanisms of soil fungal community assembly must therefore be understood to reliably predict how global changes such as climate warming and biodiversit...

  • Article
  • Open Access
5 Citations
3,056 Views
11 Pages

NK Cells from RAG- or DCLRE1C-Deficient Patients Inhibit HCMV

  • Zeguang Wu,
  • Narmadha Subramanian,
  • Eva-Maria Jacobsen,
  • Kerstin Laib Sampaio,
  • Johannes van der Merwe,
  • Manfred Hönig and
  • Thomas Mertens

The recombination-activating genes (RAGs) and the DNA cross-link repair 1C gene (DCLRE1C) encode the enzymes RAG1, RAG2 and Artemis. They are critical components of the V(D)J recombination machinery. V(D)J recombination is well known as a prerequisit...

  • Review
  • Open Access
31 Citations
5,157 Views
13 Pages

Urobiome: In Sickness and in Health

  • Bartosz Wojciuk,
  • Agata Salabura,
  • Bartłomiej Grygorcewicz,
  • Karolina Kędzierska,
  • Kazimierz Ciechanowski and
  • Barbara Dołęgowska

The human microbiome has been proven to contribute to the human condition, both in health and in disease. The metagenomic approach based on next-generation sequencing has challenged the dogma of urine sterility. The human urobiome consists of bacteri...

  • Article
  • Open Access
32 Citations
8,033 Views
24 Pages

The bacterial strain KU011TH was isolated from the skin mucus of healthy bighead catfish. The strain is a Gram-negative coccobacillus that is nonmotile, aerobic, catalase positive, oxidase negative, and nonhemolytic. Sequence analyses of the housekee...

  • Review
  • Open Access
112 Citations
16,114 Views
13 Pages

Bifidobacterium bifidum: A Key Member of the Early Human Gut Microbiota

  • Francesca Turroni,
  • Sabrina Duranti,
  • Christian Milani,
  • Gabriele Andrea Lugli,
  • Douwe van Sinderen and
  • Marco Ventura

Bifidobacteria typically represent the most abundant bacteria of the human gut microbiota in healthy breast-fed infants. Members of the Bifidobacterium bifidum species constitute one of the dominant taxa amongst these bifidobacterial communities and...

  • Article
  • Open Access
14 Citations
4,577 Views
16 Pages

Dairy industries have a high environmental impact, with very high energy and water consumption and polluting effluents. To increase the sustainability of these industries it is urgent to implement technologies for wastewater treatment allowing water...

  • Article
  • Open Access
5 Citations
3,460 Views
8 Pages

Listeria monocytogenes is a foodborne pathogen that is widely distributed in nature, having been isolated from a variety of sources such as soil, water, plant matter, and animals. In addition, L. monocytogenes is often detected in the regular samplin...

  • Article
  • Open Access
31 Citations
4,502 Views
20 Pages

Comparison of Six Commercial Meat Starter Cultures for the Fermentation of Yellow Mealworm (Tenebrio molitor) Paste

  • Borremans An,
  • Crauwels Sam,
  • Vandeweyer Dries,
  • Smets Ruben,
  • Verreth Christel,
  • Van Der Borght Mik,
  • Lievens Bart and
  • Van Campenhout Leen

In this study, six commercial meat starters, each consisting of a pure strain of a lactic acid-fermenting bacterium (including Lactococcus lactis, Lactobacillus curvatus, L. farciminis, L. plantarum, L. sakei, and Pediococcus acidilactici), were test...

  • Article
  • Open Access
36 Citations
5,778 Views
18 Pages

Isolation, Screening, and Characterization of Plant-Growth-Promoting Bacteria from Durum Wheat Rhizosphere to Improve N and P Nutrient Use Efficiency

  • Nilde Antonella Di Benedetto,
  • Daniela Campaniello,
  • Antonio Bevilacqua,
  • Mariagrazia Pia Cataldi,
  • Milena Sinigaglia,
  • Zina Flagella and
  • Maria Rosaria Corbo

The main goal of this paper was to select promising microorganisms which could potentially act as plant-growth-promoting bacteria (PGPB) for durum wheat of Foggia County. At this scope, a new statistical framework, based on multivariate analyses and...

  • Article
  • Open Access
12 Citations
3,836 Views
20 Pages

First Proteomic Approach to Identify Cell Death Biomarkers in Wine Yeasts during Sparkling Wine Production

  • Juan Antonio Porras-Agüera,
  • Jaime Moreno-García,
  • Juan Carlos Mauricio,
  • Juan Moreno and
  • Teresa García-Martínez

Apoptosis and later autolysis are biological processes which take place in Saccharomyces cerevisiae during industrial fermentation processes, which involve costly and time-consuming aging periods. Therefore, the identification of potential cell death...

  • Article
  • Open Access
7 Citations
3,329 Views
15 Pages

The Effect of Nitrogen Content on Archaeal Diversity in an Arctic Lake Region

  • Jinjiang Lv,
  • Feng Liu,
  • Wenbing Han,
  • Yu Wang,
  • Qian Zhu,
  • Jiaye Zang,
  • Shuang Wang,
  • Botao Zhang and
  • Nengfei Wang

The function of Arctic soil ecosystems is crucially important for the global climate, and nitrogen (N) is the major limiting nutrient in these environments. This study assessed the effects of changes in nitrogen content on archaeal community diversit...

  • Article
  • Open Access
14 Citations
5,393 Views
13 Pages

We investigated the ability of biofilm formation, survival, and behavior of diarrheal and emetic Bacillus cereus vegetative cells and spores in tofu. Both diarrheal and emetic B. cereus did not proliferate at a temperature below 9 °C in tofu. How...

  • Review
  • Open Access
32 Citations
6,755 Views
35 Pages

A Pyrrhic Victory: The PMN Response to Ocular Bacterial Infections

  • Erin T. Livingston,
  • Md Huzzatul Mursalin and
  • Michelle C. Callegan

Some tissues of the eye are susceptible to damage due to their exposure to the outside environment and inability to regenerate. Immune privilege, although beneficial to the eye in terms of homeostasis and protection, can be harmful when breached or w...

  • Article
  • Open Access
3 Citations
3,957 Views
17 Pages

In this work, using Saccharomyces cerevisiae as a model, we showed that BetA could inhibit cell proliferation and lead to lethal cytotoxicity accompanying programmed cell death (PCD). Interestingly, it was found that vacuolar protease Pep4p played a...

  • Article
  • Open Access
15 Citations
2,680 Views
7 Pages

Screening of Various Metabolites in Six Barley Varieties Grown under Natural Climatic Conditions (2016–2018)

  • Kristina Habschied,
  • Rudolf Krska,
  • Michael Sulyok,
  • Bojan Šarkanj,
  • Vinko Krstanović,
  • Alojzije Lalić,
  • Gordana Šimić and
  • Krešimir Mastanjević

Climatic changes influence considerably the distribution and occurrence of different secondary metabolites in cereals. The aim of this investigation was to assess the changes in metabolite prevalence observed in six different winter barley varieties...

  • Article
  • Open Access
17 Citations
5,313 Views
16 Pages

Replenishment of Hepatitis B Virus cccDNA Pool Is Restricted by Baseline Expression of Host Restriction Factors In Vitro

  • Sergey Brezgin,
  • Anastasiia Kostyusheva,
  • Ekaterina Bayurova,
  • Ilya Gordeychuk,
  • Maria Isaguliants,
  • Irina Goptar,
  • Anastasiia Nikiforova,
  • Valery Smirnov,
  • Elena Volchkova and
  • Vladimir Chulanov
  • + 2 authors

Background: Covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV) is the major cause of viral persistence in patients with chronic HBV infection. Understanding the mechanisms underlying stability and persistence of HBV cccDNA in hepatocy...

  • Article
  • Open Access
8 Citations
4,468 Views
15 Pages

Determining the Virulence Properties of Escherichia coli ST131 Containing Bacteriocin-Encoding Plasmids Using Short- and Long-Read Sequencing and Comparing Them with Those of Other E. coli Lineages

  • Ana Carolina da Cruz Campos,
  • Francis M. Cavallo,
  • Nathália L. Andrade,
  • Jan Maarten van Dijl,
  • Natacha Couto,
  • Jan Zrimec,
  • Jerome R. Lo Ten Foe,
  • Ana C. P. Rosa,
  • Paulo V. Damasco and
  • John W. A. Rossen
  • + 2 authors

Escherichia coli ST131 is a clinical challenge due to its multidrug resistant profile and successful global spread. They are often associated with complicated infections, particularly urinary tract infections (UTIs). Bacteriocins play an important ro...

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Microorganisms - ISSN 2076-2607