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Journal of Personalized Medicine, Volume 15, Issue 7

July 2025 - 64 articles

Cover Story: Genetic variants in cytochrome P450 (CYP) enzymes, particularly CYP2C9 and CYP2C19, have significant impacts on drug metabolism, influencing therapeutic efficacy and adverse drug reactions. While allele frequency studies commonly group diverse populations under broad categories such as “Asian” or “European”, such grouping masks critical intra-regional and ethnic variation. The lumping of diverse regional and cultural groups into a major racial categorization can perpetuate gaps in pharmacogenetic knowledge and widen existing health disparities. Herein, we present a case study that disaggregates major allele frequencies of CYP2C9 and CYP2C19 into multiple Asian and European cohorts. By highlighting population-specific genetic diversity, our work aims to refine pharmacogenomic dosing guidelines and support truly individualized medicine strategies. View this paper
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Articles (64)

  • Article
  • Open Access
643 Views
16 Pages

Long-Term Outcome of Unprotected Left Main Percutaneous Coronary Interventions—An 8-Year Single-Tertiary-Care-Center Experience

  • Orsolya Nemeth,
  • Tamas Ferenci,
  • Tibor Szonyi,
  • Sandor Szoke,
  • Gabor Fulop,
  • Tunde Pinter,
  • Geza Fontos,
  • Peter Andreka and
  • Zsolt Piroth

15 July 2025

Background/Objectives: Randomized studies of patients with unprotected left main coronary artery (ULMCA) disease involve highly selected populations. Therefore, we sought to investigate the 60-month event-free survival of consecutive patients undergo...

  • Systematic Review
  • Open Access
1 Citations
1,712 Views
46 Pages

Key Determinants Influencing Treatment Decision-Making for and Adherence to Active Surveillance for Prostate Cancer: A Systematic Review

  • Pani Nasseri,
  • Jorien Veldwijk,
  • Christa Niehot,
  • Esmee F. H. Mulder,
  • Esther W. de Bekker-Grob,
  • Monique J. Roobol and
  • Lionne D. F. Venderbos

15 July 2025

Background/Objectives: Men choosing active surveillance (AS) for low- and intermediate risk prostate cancer (PCa) must weigh its harms and benefits against those of active treatment (AT). To understand factors influencing treatment decision-making (T...

  • Article
  • Open Access
790 Views
20 Pages

14 July 2025

Background/Objectives: This study aimed to evaluate a regional implementation project for rural emergency care (RuralRescue) and to examine how its components and outcomes may support personalized approaches in emergency medicine. While not originall...

  • Article
  • Open Access
569 Views
10 Pages

Psychiatric Comorbidities Associated with Food Addiction in Post-Bariatric Patients: Toward Personalized Mental Health Screening and Postoperative Care

  • Ligia Florio,
  • Maria Olivia Pozzolo Pedro,
  • Kae Leopoldo,
  • Maria Amalia Accari Pedrosa and
  • João Mauricio Castaldelli-Maia

14 July 2025

Background: Food addiction (FA) is an emerging construct that mirrors the behavioral and neurobiological characteristics of substance use disorders. Despite growing interest, its association with specific psychiatric disorders among bariatric patient...

  • Article
  • Open Access
1 Citations
858 Views
13 Pages

Stereotactic Body Radiotherapy for the Treatment of Oligometastases Located in the Peritoneum or in the Abdominal Wall: Preliminary Results from a Mono-Institutional Analysis

  • Francesco Cuccia,
  • Salvatore D’Alessandro,
  • Marina Campione,
  • Vanessa Figlia,
  • Gianluca Mortellaro,
  • Antonio Spera,
  • Giulia Musicò,
  • Antonino Abbate,
  • Salvatore Russo and
  • Carlo Messina
  • + 3 authors

14 July 2025

Purpose/Objective(s): Peritoneal carcinosis can occur in several gastrointestinal or gynecological malignancies and its prognosis is usually poor. With the advent of more effective systemic agents, the overall survival of metastatic patients has been...

  • Review
  • Open Access
1,591 Views
14 Pages

14 July 2025

Background: Pneumocystis jirovecii pneumonia (PJP) remains a serious threat to non-HIV immunocompromised patients, who often experience rapid disease progression, delayed diagnosis, and higher mortality. Standard treatment with high-dose trimeth...

  • Article
  • Open Access
1,321 Views
12 Pages

The Role of Neutrophil-to-Lymphocyte Ratio as a Predictor of Orchiectomy or Testicular Atrophy After Torsion in Children: A Multicentric Study

  • Carlos Delgado-Miguel,
  • Javier Arredondo-Montero,
  • Julio César Moreno-Alfonso,
  • Isabella Garavis Montagut,
  • María San Basilio,
  • Irene Hernández,
  • Noela Carrera,
  • Leopoldo Martínez,
  • Estíbalitz Iraola and
  • Inmaculada Ruiz Jiménez
  • + 4 authors

13 July 2025

Introduction: Neutrophil-to-lymphocyte ratio (NLR) is an inflammatory biomarker (hemogram-derived-ratio) related to ischemic-inflammatory diseases. Its usefulness in the diagnosis of pediatric testicular torsion (TT) has recently been reported, altho...

  • Review
  • Open Access
1 Citations
1,005 Views
19 Pages

13 July 2025

Background/Objectives: Olfactory neuroblastoma (ONB), also known as esthesioneuroblastoma, is a rare neuroectodermal malignancy of the nasal cavity characterized by aggressive local invasion and variable metastatic potential, with diverse clinical be...

  • Article
  • Open Access
1 Citations
1,130 Views
13 Pages

An Artificial Intelligence-Based Model to Predict Pregnancy After Intrauterine Insemination: A Retrospective Analysis of 9501 Cycles

  • Jaume Minano Masip,
  • Camille Grysole,
  • Penelope Borduas,
  • Isaac-Jacques Kadoch,
  • Simon Phillips,
  • Doina Precup and
  • Daniel Dufort

12 July 2025

Background/Objectives: Intrauterine insemination (IUI) is a common first-line approach in the treatment of numerous infertile couples, especially in cases of unexplained infertility. Its relatively low success rate, however, could benefit from the de...

  • Article
  • Open Access
686 Views
10 Pages

A Value Framework for Evaluating Population Genomic Programs: A Mixed Methods Approach

  • David Campbell,
  • Scott Spencer,
  • Ashley Kang,
  • Rajshree Pandey,
  • Sarah Katsandres and
  • David Veenstra

12 July 2025

Background/Objectives: Value frameworks are useful tools to explicitly define the dimensions and criteria important for decision-making, but no existing frameworks capture the broad value domains of population genomic programs. Using a mixed methods...

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J. Pers. Med. - ISSN 2075-4426Creative Common CC BY license