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Special Issues
Gastrointestinal Cancers: New Advances and Challenges
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Gastrointestinal Cancers: New Advances and Challenges

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: closed (25 June 2025) | Viewed by 1393

Special Issue Editor

Dr. Yasuo Imai

E-Mail Website
Guest Editor
Department of Diagnostic Pathology, Ota Memorial Hospital, Gunma 373-8585, Japan
Interests: cancer diagnostics; cancer biology; ATP-binding cassette transporters; gastrointestinal oncology; tumor markers; tumor biology; molecular oncology; diagnostic pathology; anticancer drug resistance; progesterone receptors; human erbb2 protein; breast neoplasms; neuroendocrine carcinoma; synaptophysin; chromogranins; pancreaticoduodenectomy; neoadjuvant therapy; mesenteric veins
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce that we will call for contributions for publication in JPM’s Special Issue, titled Gastrointestinal Cancers: New Advances and Challenges. Today, various guidelines for the treatment of gastrointestinal cancers based on large-scale clinical studies are being developed around the world, and many patients can benefit from standardized treatment. On the other hand, excessive indications of standardized treatment may impede optimal advanced medical care for individual patients. Gastrointestinal oncology is progressing day by day, and new disease concepts, new pathogenic mechanisms, and new diagnostic and therapeutic modalities are being developed one after another. This Special Issue seeks all types of contributions on diagnostic problems and solutions, the efficacy and limitations of standardized treatments, approaches to individualized treatments, novel and challenging diagnostic and therapeutic modalities, and their clinical experiences. It is important to share your knowledge and experience with our readers, and we therefore consider papers on negative data and unsuccessful cases, among other things.

Dr. Yasuo Imai
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gastrointestinal cancer
  • guideline
  • disease concept
  • mechanism of disease
  • diagnosis
  • endoscopy
  • surgery
  • chemotherapy
  • molecular targeted therapy
  • immunotherapy

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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13 pages, 1412 KiB  
Article
Comparative Changes in Fecal Microbiome After Endoscopic Resection and Surgical Resection in Gastric Cancer Patients
by Hochan Seo, Jae Yong Park, Hee Sang You, Beom Jin Kim and Jae Gyu Kim
J. Pers. Med. 2025, 15(4), 144; https://doi.org/10.3390/jpm15040144 - 4 Apr 2025
Cited by 1 | Viewed by 564
Abstract
Background/Objectives: Gastric cancer treatments can lead to significant alterations to patients’ gastrointestinal microbiome. However, differences in microbial impacts between gastrectomy and endoscopic submucosal dissection (ESD) remain underexplored. This study investigates how these treatments influence microbial diversity and composition in patients with stage [...] Read more.
Background/Objectives: Gastric cancer treatments can lead to significant alterations to patients’ gastrointestinal microbiome. However, differences in microbial impacts between gastrectomy and endoscopic submucosal dissection (ESD) remain underexplored. This study investigates how these treatments influence microbial diversity and composition in patients with stage I gastric cancer. Methods: Patients with pathologically confirmed stage I gastric cancer were recruited from Chung-Ang University Hospital between December 2016 and December 2019. This study analyzed fecal samples from 13 patients (ESD: n = 5; gastrectomy: n = 8) before and after treatment using 16S rRNA gene sequencing. Microbial diversity indices and taxonomic composition were compared, with follow-up extending up to two years. Results: In the total cohort, alpha diversity significantly decreased post-treatment (p < 0.05), and beta diversity analysis showed distinct clustering between pre- and post-treatment samples (p < 0.05). At the genus level, Bacteroides significantly decreased (p < 0.05), while Lactobacillus, Bifidobacterium, and Blautia showed significant increases (p < 0.05). Comparative analyses revealed that in the ESD group, alpha diversity remained unchanged, although beta diversity showed significant clustering (p < 0.05), without notable changes in major taxa. In contrast, surgical resection resulted in a significant reduction in alpha diversity (p < 0.05) and beta diversity clustering (p < 0.05), with increased abundances of Streptococcus and Blautia and decreased abundance of Bacteroides (p < 0.05). Conclusions: Surgical gastrectomy exerts significant effects on microbiome diversity and composition, while ESD has a more limited impact. These findings underscore the importance of considering microbiome changes in postoperative management. Full article
(This article belongs to the Special Issue Gastrointestinal Cancers: New Advances and Challenges)
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39 pages, 3875 KiB  
Systematic Review
Early vs. Late Oral Feeding After Surgery for Patients with Esophageal Malignancy: A Systematic Review and Meta-Analysis of Postoperative Clinical Outcomes and Quality of Life
by Raghad Fahad Alrasheed, Abdullah Salem Laradhi, Reema Saeed Alqahtani, Sarah Mazin Alharthi, Waleed Amin Alamoudi, Zainudheen Faroog, Sham Yasser Almohammad, Jana Ayman Basmaih, Nasser Turki Alotaibi, Ahmed Elaraby, Raed A. Albar and Ayman M. A. Mohamed
J. Pers. Med. 2025, 15(7), 317; https://doi.org/10.3390/jpm15070317 - 15 Jul 2025
Viewed by 310
Abstract
Introduction: Esophagectomy for esophageal cancer traditionally involves delayed postoperative oral feeding due to concerns about complications like anastomotic leakage. Enhanced Recovery After Surgery (ERAS) protocols favor early oral feeding (EOF), but its safety and benefits remain debated. This systematic review and meta-analysis compared [...] Read more.
Introduction: Esophagectomy for esophageal cancer traditionally involves delayed postoperative oral feeding due to concerns about complications like anastomotic leakage. Enhanced Recovery After Surgery (ERAS) protocols favor early oral feeding (EOF), but its safety and benefits remain debated. This systematic review and meta-analysis compared EOF versus late oral feeding (LOF) after esophagectomy. Methods: We systematically searched PubMed, Scopus, Web of Science, EMBASE, and the Cochrane Library through March 2025 for primary studies comparing EOF (≤7 days post-op) with LOF (>7 days or delayed) in adult patients after esophagectomy. Outcomes included anastomotic leakage, pneumonia, other complications, gastrointestinal recovery, length of hospital stay (LOS), quality of life (QoL), and mortality. Results: Twenty-nine studies involving 3962 patients were included. There was no significant difference in the risk of anastomotic leakage between the two groups (RR: 1.03, 95% CI: 0.80–1.33, p = 0.82, I2 = 0%). EOF was associated with a significantly shorter time to first flatus (Cohen’s d: −1.26, 95% CI: −1.93 to −0.58, p < 0.001) and first defecation (Cohen’s d: −0.87, 95% CI: −1.51 to −0.22, p = 0.01) and a shorter LOS (p = 0.01). No significant differences were found for other complications (acute respiratory distress syndrome [ARDS], chyle leak, conduit issues, ileus, sepsis, wound infection) or mortality rates (in-hospital, 30-day, 90-day, overall). QoL assessment suggested potential improvement in emotional function with EOF. Conclusions: EOF after esophagectomy appears safe, as it does not increase the risk of anastomotic leakage or other major complications compared to LOF. It is associated with faster gastrointestinal recovery and shorter hospital stays, supporting its use within ERAS protocols. Full article
(This article belongs to the Special Issue Gastrointestinal Cancers: New Advances and Challenges)
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