Table of Contents
Diagnostics, Volume 8, Issue 4 (December 2018)
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Cover Story (view full-size image) Clinical microbiology is experiencing the emergence of the syndromic approach of diagnosis. To [...] Read more. Clinical microbiology is experiencing the emergence of the syndromic approach of diagnosis. To address this challenge, we have developed an innovative technology based on DNA microarray, which allows one to detect and discriminate between 11 bacteria, implicated in respiratory infectious diseases. The diagnostic is obtained in less than 4 h as a predictive value of the presence/ absence of pathogens using a decision algorithm based on the machine –learning method. Our technology converged at > 95% with diagnostics by classical microbiological culture. In conclusion, while our technology is still at the prototype stage and requires some automation, it has the potential to surpass the actual multiplex (end-point) real-time PCR technique due to its higher throughput capacity to detect a higher number of microbes per biological sample and to treat a higher number of samples per day. View this paper