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Diagnostics 2018, 8(4), 75; https://doi.org/10.3390/diagnostics8040075

Liquid Biopsy in Gastrointestinal Cancers

Division of Vascular and Interventional Radiology, Laboratory for Minimally Invasive Therapeutics, Mayo Clinic, Phoenix, AZ 85054, USA
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Received: 25 September 2018 / Revised: 24 October 2018 / Accepted: 24 October 2018 / Published: 29 October 2018
(This article belongs to the Special Issue Imaging-Based Diagnostics in Interventional Medicine)
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Abstract

Liquid biopsy is the sampling of any biological fluid in an effort to enrich and analyze a tumor’s genetic material. Peripheral blood remains the most studied liquid biopsy material, with circulating tumor cells (CTC’s) and circulating tumor DNA (ctDNA) allowing the examination and longitudinal monitoring of a tumors genetic landscape. With applications in cancer screening, prognostic stratification, therapy selection and disease surveillance, liquid biopsy represents an exciting new paradigm in the field of cancer diagnostics and offers a less invasive and more comprehensive alternative to conventional tissue biopsy. Here, we examine liquid biopsies in gastrointestinal cancers, specifically colorectal, gastric, and pancreatic cancers, with an emphasis on applications in diagnostics, prognostics and therapeutics. View Full-Text
Keywords: liquid biopsy; circulating tumor cells; circulating tumor DNA; gastrointestinal cancer liquid biopsy; circulating tumor cells; circulating tumor DNA; gastrointestinal cancer
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Saini, A.; Pershad, Y.; Albadawi, H.; Kuo, M.; Alzubaidi, S.; Naidu, S.; Knuttinen, M.-G.; Oklu, R. Liquid Biopsy in Gastrointestinal Cancers. Diagnostics 2018, 8, 75.

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