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Diagnostics 2018, 8(4), 74;

Point-of-Care/Chairside aMMP-8 Analytics of Periodontal Diseases’ Activity and Episodic Progression

Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, PO Box 63 (Haartmaninkatu 8), 00014 Helsinki, Finland
Institute for Molecular Diagnostics (IMOD), Bonner Str. 84, 42697 Solingen, Germany
Division of Periodontology, Department of Dental Medicine, Karolinska Institute, SE-171 77 Stockholm, Sweden
Author to whom correspondence should be addressed.
Received: 27 September 2018 / Revised: 15 October 2018 / Accepted: 18 October 2018 / Published: 22 October 2018
(This article belongs to the Special Issue Novel Point-of-Care Technologies in Diagnostics 2018)
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Traditional periodontal disease diagnostics are based mainly on clinical examination and radiographs. They assess only past tissue destruction and provide no information on the current disease status or its future progression. The objective is to find out if an active matrix metalloproteinase-8 (aMMP-8) point-of-care (PoC) test could provide a cost-effective way to get around this limitation. This cross-sectional study used 47 adolescents and 70 adults, who were clinically examined and their aMMP-8 PoC tested. The aMMP-8 PoC test results and patients’ treatment need, based on the community periodontal index of treatment needs (CPITN), were compared and analyzed using Fisher’s exact test. In terms of CPITN, the aMMP-8 PoC test gave no false positives for both adolescents and adults. All healthy patients got a negative test result, while a positive test result indicated periodontal treatment need correctly. Finally, there was a significant association between a patient’s aMMP-8 PoC test result and his/her treatment need (p = 0.001 for adolescents, p = 0.001 for adults). In conclusion, more accurate diagnostics of periodontal diseases’ activity and progression using an aMMP-8 PoC test may help to reduce oral health care costs by reducing patient overtreatment, improving patient outcome, and reducing the need for complex periodontal therapy. View Full-Text
Keywords: matrix metalloproteinases; periodontal diseases; periodontitis; point-of-care testing matrix metalloproteinases; periodontal diseases; periodontitis; point-of-care testing

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Räisänen, I.T.; Heikkinen, A.M.; Siren, E.; Tervahartiala, T.; Gieselmann, D.-R.; Van der Schoor, G.-J.; Van der Schoor, P.; Sorsa, T. Point-of-Care/Chairside aMMP-8 Analytics of Periodontal Diseases’ Activity and Episodic Progression. Diagnostics 2018, 8, 74.

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