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Diagnostics 2018, 8(4), 68; https://doi.org/10.3390/diagnostics8040068

Liquid Biopsy Potential Biomarkers in Prostate Cancer

Department of Urology, Research Laboratory, University Leipzig, D-04103 Leipzig, Germany
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Received: 9 August 2018 / Revised: 12 September 2018 / Accepted: 14 September 2018 / Published: 21 September 2018
(This article belongs to the Special Issue Diagnostic Biomarkers in Prostate Cancer)
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Abstract

Prostate cancer (PCa) is the second most common cancer in men worldwide with an incidence of 14.8% and a mortality of 6.6%. Shortcomings in comprehensive medical check-ups in low- and middle-income countries lead to delayed detection of PCa and are causative of high numbers of advanced PCa cases at first diagnosis. The performance of available biomarkers is still insufficient and limited applicability, including logistical and financial burdens, impedes comprehensive implementation into health care systems. There is broad agreement on the need of new biomarkers to improve (i) early detection of PCa, (ii) risk stratification, (iii) prognosis, and (iv) treatment monitoring. This review focuses on liquid biopsy tests distinguishing high-grade significant (Gleason score (GS) ≥ 7) from low-grade indolent PCa. Available biomarkers still lack performance in risk stratification of biopsy naïve patients. However, biomarkers with highly negative predictive values may help to reduce unnecessary biopsies. Risk calculators using integrative scoring systems clearly improve decision-making for invasive prostate biopsy. Emerging biomarkers have the potential to substitute PSA and improve the overall performance of risk calculators. Until then, PSA should be used and may be replaced whenever enough evidence has accumulated for better performance of a new biomarker. View Full-Text
Keywords: prostate cancer (PCa); biomarkers; liquid biopsy; diagnosis high-grade PCa; risk stratification; risk calculators prostate cancer (PCa); biomarkers; liquid biopsy; diagnosis high-grade PCa; risk stratification; risk calculators
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Neuhaus, J.; Yang, B. Liquid Biopsy Potential Biomarkers in Prostate Cancer. Diagnostics 2018, 8, 68.

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