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Diagnostics, Volume 8, Issue 3

September 2018 - 26 articles

Cover Story: The featured review in this issue of Diagnostics discusses current strategies in prostate cancer management—from diagnosis, therapy, and prognosis—while emphasizing the unmet need of stratifying patients for optimal care. Recent genomic, transcriptomic, and epigenomic analyses uncovering the spectrum of molecular heterogeneity in both localized and advanced disease, and the emergence of molecular signatures in pre-clinical and clinical settings underscore the plausibility of applying precision medicine in this cancer entity. View this paper.

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Articles (26)

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Article

9 Citations

7,803 Views

14 Pages

ALTEA: A Software Tool for the Evaluation of New Biomarkers for Alzheimer’s Disease by Means of Textures Analysis on Magnetic Resonance Images

Carlos López-Gómez,
Rafael Ortiz-Ramón,
Enrique Mollá-Olmos,
David Moratal and
For the Alzheimer’s Disease Neuroimaging Initiative

Diagnostics2018, 8(3), 47;https://doi.org/10.3390/diagnostics8030047

19 July 2018

The current criteria for diagnosing Alzheimer’s disease (AD) require the presence of relevant cognitive deficits, so the underlying neuropathological damage is important by the time the diagnosis is made. Therefore, the evaluation of new biomarkers t...

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Article

8 Citations

5,106 Views

9 Pages

The Frequency of Focal Thyroid Incidental Findings and Risk of Malignancy Detected by 18F-Fluorodeoxyglucose Positron Emission Tomography in an Iodine Deficient Population

Nina Gedberg,
Jesper Karmisholt,
Michael Gade,
Rune V. Fisker,
Victor Iyer and
Lars J. Petersen

Diagnostics2018, 8(3), 46;https://doi.org/10.3390/diagnostics8030046

17 July 2018

Incidental focal uptake of 18F-fluorodeoxyglucose (FDG) in the thyroid on positron emission tomography (PET/CT) is rare but often associated with malignancy. The epidemiology of thyroid incidentalomas has only to some extent been described in countri...

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Review

54 Citations

13,025 Views

11 Pages

Whole-Body MRI with Diffusion-Weighted Imaging in Bone Metastases: A Narrative Review

Alessandro Stecco,
Alessandra Trisoglio,
Eleonora Soligo,
Sara Berardo,
Lidiia Sukhovei and
Alessandro Carriero

Diagnostics2018, 8(3), 45;https://doi.org/10.3390/diagnostics8030045

9 July 2018

Whole body magnetic resonance imaging (MRI) with diffusion-weighted imaging (WB-MRI-DWI) is currently emerging as a diagnostic technique in the evaluation of bone metastases from breast, prostate, lung, thyroid, and melanoma tumors. The most relevant...

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Article

2 Citations

6,013 Views

11 Pages

Utility of Two-Dimensional Difference Gel Electrophoresis in Diagnosis of Multiple Sclerosis

Michael Auer,
Harald Hegen,
Dagmar Rudzki,
Georg Golderer and
Florian Deisenhammer

Diagnostics2018, 8(3), 44;https://doi.org/10.3390/diagnostics8030044

5 July 2018

Two-dimensional difference gel electrophoresis (2D-DIGE) has been used for identification of possible biomarkers in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients. However, in different studies inconsistent results have been obtain...

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Article

14 Citations

6,125 Views

10 Pages

Evaluation of 2D Imaging Schemes for Pulsed Arterial Spin Labeling of the Human Kidney Cortex

Charlotte E. Buchanan,
Eleanor F. Cox and
Susan T. Francis

Diagnostics2018, 8(3), 43;https://doi.org/10.3390/diagnostics8030043

28 June 2018

A number of imaging readout schemes are proposed for renal arterial spin labeling (ASL) to quantify kidney cortex perfusion, including gradient echo-based methods of balanced fast field echo (bFFE) and gradient-echo echo-planar imaging (GE-EPI), or s...

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Review

23 Citations

8,261 Views

24 Pages

Neural Indicators of Fatigue in Chronic Diseases: A Systematic Review of MRI Studies

María Goñi,
Neil Basu,
Alison D. Murray and
Gordon D. Waiter

Diagnostics2018, 8(3), 42;https://doi.org/10.3390/diagnostics8030042

21 June 2018

While fatigue is prevalent in chronic diseases, the neural mechanisms underlying this symptom remain unknown. Magnetic resonance imaging (MRI) has the potential to enable us to characterize this symptom. The aim of this review was to gather and appra...

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