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Diagnostics 2018, 8(3), 45; https://doi.org/10.3390/diagnostics8030045

Whole-Body MRI with Diffusion-Weighted Imaging in Bone Metastases: A Narrative Review

Ospedale Maggiore della Carità di Novara, Istituto di Radiodiagnostica ed Interventistica, Università del Piemonte Orientale, Amedeo Avogadro, Corso Giuseppe Mazzini 18, 28100 Novara, Italy
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Received: 4 April 2018 / Revised: 29 May 2018 / Accepted: 4 July 2018 / Published: 9 July 2018
(This article belongs to the Special Issue Imaging of Bone Metastases in Oncology)
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Abstract

Whole body magnetic resonance imaging (MRI) with diffusion-weighted imaging (WB-MRI-DWI) is currently emerging as a diagnostic technique in the evaluation of bone metastases from breast, prostate, lung, thyroid, and melanoma tumors. The most relevant articles regarding the detection of solid tumor bone metastases with MRI have been reviewed and cited. The imaging methods currently used in the detection of bone metastases are bone scintigraphy, computed tomography (CT), and positron emission tomography (PET/CT) with 2-deoxy-2-[fluorine-18] fluoro-d-glucose (18F-FDG PET/CT). WB-MRI-DWI allows qualitative and quantitative evaluation of focal lesions through signal intensity evaluation on DWI images and the reconstruction of the apparent diffusion coefficient (ADC) map. In prostate and breast cancer, WB-MRI-DWI is useful in assessing the response of bone lesions to therapy and to detecting early non-responders, while in lung cancer the method shows a similar sensitivity to 18F-FDG PET/CT in the detection of bone metastases. In bone metastases of thyroid tumors and melanoma, the WB-MRI-DWI shows a higher sensitivity when compared to 18F-FDG PET/CT. With a standardization of the WB-MRI-DWI protocol, this method seems to play an important role in the diagnosis of bone solid tumor metastases. View Full-Text
Keywords: whole-body magnetic resonance imaging; diffusion-weighted imaging; bone metastasis; lung cancer; breast cancer; thyroid cancer; melanoma whole-body magnetic resonance imaging; diffusion-weighted imaging; bone metastasis; lung cancer; breast cancer; thyroid cancer; melanoma
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Stecco, A.; Trisoglio, A.; Soligo, E.; Berardo, S.; Sukhovei, L.; Carriero, A. Whole-Body MRI with Diffusion-Weighted Imaging in Bone Metastases: A Narrative Review. Diagnostics 2018, 8, 45.

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