Biomarkers of Gynecological Cancers

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 901

Special Issue Editor


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Guest Editor
Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9WL, UK
Interests: biomarker research; cancer proteomics; clinical oncology; cancer sciences; epidemiology

Special Issue Information

Dear Colleagues,

This Special Issue, "Biomarkers of Gynecological Cancers", aims to provide a comprehensive overview of the current state of knowledge regarding biomarkers for ovarian, uterine, and cervical cancers. It seeks to highlight recent advancements in the discovery, validation, and clinical application of biomarkers in these gynecological malignancies. The scope of this Special Issue encompasses studies on novel biomarkers, their diagnostic as well as prognostic potential, and their role in guiding personalized treatment strategies. It aims to bring together researchers from diverse fields, including oncology, gynecology, molecular biology, and clinical trials, to discuss the latest findings and challenges in the field of gynecological cancer biomarkers. Through this platform, this Special Issue aims to foster collaboration and advance the development of more effective biomarkers for the early detection, prognosis, and management of gynecological cancers.

Dr. Kelechi Njoku
Guest Editor

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Keywords

  • biomarkers
  • gynecological cancer
  • cervical cancer
  • ovarian cancer
  • uterine cancer
  • endometrial cancer

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Published Papers (1 paper)

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Review

20 pages, 557 KB  
Review
Prognostic Role of L1CAM in Endometrial Cancer
by Mousa Mobarki
Diagnostics 2025, 15(16), 2115; https://doi.org/10.3390/diagnostics15162115 - 21 Aug 2025
Viewed by 535
Abstract
The L1 molecule is a cell adhesion molecule (L1CAM) that was originally implicated in neuronal development. In recent years, studies of several large cohorts of patients with endometrial cancer have revealed that L1CAM acts as a poor prognostic factor, in most cases independent [...] Read more.
The L1 molecule is a cell adhesion molecule (L1CAM) that was originally implicated in neuronal development. In recent years, studies of several large cohorts of patients with endometrial cancer have revealed that L1CAM acts as a poor prognostic factor, in most cases independent of other parameters. It seems to be an important factor, especially in the non-specific molecular profile subgroup (p53 normal expression, MMR proficient, POLE not mutated) of endometrial cancer, and a factor predictive of the response to chemotherapy. This review aims to gather most of the current knowledge regarding this promising prognostic factor. Full article
(This article belongs to the Special Issue Biomarkers of Gynecological Cancers)
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