Noninvasive Diagnosis in Dermatology

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: closed (30 June 2025) | Viewed by 409

Special Issue Editor


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Guest Editor
Department of Dermatology, National Institute of Infectious Diseases Lazzaro Spallanzani, Rome, Italy
Interests: innovative therapies in dermatology; vulnology; skin regeneration

Special Issue Information

Dear Colleagues,

In recent years, there have been significant advancements in non-invasive methods for the diagnosis of dermatological diseases. Non-invasive diagnosis has become an essential tool in modern dermatology. These techniques, such as dermatoscopy, confocal microscopy, and optical coherence tomography, provide high-resolution images of skin lesions, enabling physicians to visualize and analyze skin conditions with unprecedented precision. Advances in these techniques have allowed us to correlate the observed changes with the pathology, leading to more accurate diagnoses.

This Special Issue aims to provide a comprehensive overview of the recent advancements in non-invasive skin imaging techniques, discuss their current use in clinical practice, and shed light on the exciting future prospects in this field.

Dr. Alessandra Scarabello
Guest Editor

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Keywords

  • dermoscopy
  • confocal microscopy
  • optical coherence tomography
  • skin cancer
  • skin disorders

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Published Papers (1 paper)

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Research

8 pages, 358 KiB  
Communication
Exploring Laser-Induced Plasma Spectroscopy for Skin Cancer Patients: A Preliminary Study
by Dimitrios Sgouros, Emmanouil Karampinis, Melpomeni Theofili, Georgia Pappa, Panagiotis Theofilis, Sofia Theotokoglou, Anna Syrmali and Alexander Katoulis
Diagnostics 2025, 15(16), 2116; https://doi.org/10.3390/diagnostics15162116 - 21 Aug 2025
Abstract
Skin cancer is the most frequently diagnosed form of cancer worldwide. Diagnostic uncertainty can arise when macroscopic or dermoscopic evaluations do not clearly differentiate between benign and malignant lesions. Laser-induced plasma spectroscopy (LIPS), traditionally used in fields like materials science and environmental analysis, [...] Read more.
Skin cancer is the most frequently diagnosed form of cancer worldwide. Diagnostic uncertainty can arise when macroscopic or dermoscopic evaluations do not clearly differentiate between benign and malignant lesions. Laser-induced plasma spectroscopy (LIPS), traditionally used in fields like materials science and environmental analysis, has recently gained attention for its applications in human tissue assessment. LIPS works by generating a (micro)plasma when a laser interacts with tissue, producing element-specific light emissions that can be analyzed in real time. In this study, we explored the potential of LIPS to differentiate between benign and malignant skin lesions using the Spectra-Scope® Score (SSS). Our results revealed a clear distinction: benign lesions showed a median SSS of 1.7, while suspicious and malignant lesions had a significantly higher median score of 8.1 (p < 0.001). Receiver operating characteristic (ROC) curve analysis demonstrated strong diagnostic performance, with an area under the curve (AUC) of 0.82 (p < 0.001). The findings of this preliminary study support the high accuracy of LIPS in identifying malignancy and underscore its promise as a non-invasive, real-time diagnostic aid. Integrating SSS into clinical workflows could enhance the early detection of skin cancer and reduce reliance on invasive diagnostic procedures. However, further validation is needed to fully establish its role in routine dermatological practice. Full article
(This article belongs to the Special Issue Noninvasive Diagnosis in Dermatology)
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