The Molecular and Cellular Basis for Rheumatoid Arthritis

Dear Colleagues,

Understanding of the pathogenesis of rheumatoid arthritis (RA) has been accumulated over the last few decades. Various inflammatory cytokines and cytokine pathways have been revealed to be involved and many molecular target therapies are already successfully provided to patients. Rheumatoid factor and anti-citrullinated protein antibody production are the key characteristics of RA and the association with chronic certain bacterial infections has been highlighted these days, which might lead to a new approach to treat RA or to prevent RA development.

In this Special Issue, we would like to overview the current knowledge of the molecular and cellular mechanisms in RA pathogenesis, especially focusing on omics analyses including genomics, epigenomics, transcriptomics, proteomics, metabolomics and the microbiome, as well as on cellular and cytokine networks related to RA. Furthermore, we would like to refer to the pathogenesis of sero-negative RA, which is not as well-understood as sero-positive RA.

We hope this Special Issue becomes a good textbook of the understanding of the molecular and cellular mechanisms of RA development, and will provide novel insight to readers.

Assoc. Prof. Koichiro Ohmura
Guest Editor

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