Special Issue "Alternative Splicing: Recent Insights into Mechanisms and Functional Roles"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (15 November 2019).
Interests: alternative splicing; RNA metabolism; cancer; RNA binding proteins; ALS
Interests: alternative splicing; mRNA processing; RNA binding proteins; angiogeneis; vanscular biology; cancer
Alternative splicing is a post-transcriptional mechanism of gene expression generating multiple mature mRNA isoforms from the precursor mRNA, thus representing a fundamental step to expand the transcriptomic and proteomic diversity in multicellular organisms. A number of alternative splicing events are evolutionarily conserved among species, whereas others generate protein variants that selectively regulate cell-, tissue-, or development-specific programs in vertebrates. Moreover, several alternatively spliced exons encode for domains mediating protein–protein interactions or association with different ligands, thus supporting an important function in modulating highly connected protein networks or signaling pathways, with relevance in human diseases. In this regard, alternative splicing has recently emerged as a druggable mechanism, exploitable to ameliorate, or even cure, many human pathologies, including cancer.
Despite our recent progress in many computational and experimental approaches, our knowledge of the mechanisms or factors that generate specific alternative splicing variants as well as their roles in physiologically (or pathologically) relevant processes is still limited. The main goal of this Special Issue is to collect recent insights into the mechanisms and functional roles of alternative splicing regulation, how it operates to control or cooperate with other gene expression regulatory processes, its contribution to cell- and tissue-specific programs, and its alteration in human diseases.
Prof. Maria Paola Paronetto
Dr. Claudia Ghigna
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- alternative splicing
- gene expression
- tissue-specific programs
- splicing dysregulation in human diseases
- RNA therapeutics