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Special Issue "Glycation and Dicarbonyl Stress in Aging and Disease"
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (30 September 2019).
Interests: reactive oxygen species; oxidative stress; redox-responsive pathways; dicarbonyl stress; glycation; methylglyoxal; aging; adaptive response; hormesis; stress response
* h-index: 26
Aging and several age-related diseases share important biochemical and molecular features, in which dicarbonyl stress (DS) and the subsequent glycation process play a key role. DS originates from the increased formation and/or decreased removal of toxic dicarbonyl metabolites, especially methylglyoxal. This, if not counteracted by cellular defense mechanisms, leads to the formation of advanced glycation end-products (AGEs), with consequent cell and tissue dysfunction. Moreover, DS may also derive from exposure to or the intake of exogenous dicarbonyls and AGEs (e.g. through the diet). The accumulation of AGEs has been linked to the activation of pro-inflammatory and pro-oxidant pathways, thus exacerbating the cellular stress. These events are frequently observed in many age-associated pathologies, such as diabetes, cancer, neurodegenerations and cardiovascular diseases. Due to the relevant socio-economic impact, great efforts are currently being undertaken to identify molecular targets able to prevent or limit DS-dependent cell damage.
The aim of this Special Issue is to provide a collection of original and review articles aimed at improving the understanding of the mechanisms underlying the toxicity of AGEs and dicarbonyls in cells and tissues. Studies on innovative strategies, including nutraceutical approaches, to modulate DS-activated intracellular signalling are also welcome.
Prof. Fernanda Amicarelli
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Dicarbonyl stress
- dicarbonyl compounds
- advanced glycation end products (AGEs)
- advanced lipoxidation end products (ALEs)
- oxidative stress
- stress response
- neurodegenerative disease