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Cells, Volume 14, Issue 21

2025 November-1 - 102 articles

Cover Story: In the central nervous system, connexin 43 (Cx43) is an essential protein responsible for glial communication. Recently, several studies have reported that, in addition to neuronal networks, astrocytes contribute to the regulation of energy balance. Here, we investigate the impact of Cx43 knockdown on the regulation of energy homeostasis by targeting, specifically, the astrocytes of the dorsal vagal complex (DVC). The DVC is a brainstem structure involved in the homeostatic control of energy balance. Our results show that knockdown of glial Cx43 is accompanied by a strong astrocytic and microglial remodeling but a limited alteration of energy metabolism. These results suggest that astrocytic and microglia plasticity may constitute a buffering system that preserves metabolic outputs when glial communication within the DVC is altered. View this paper

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1 Citations

1,213 Views

18 Pages

Nicotinamide Counteracts the Detrimental Effect of Endothelin-1 on Uterine Decidualization During Early Pregnancy by Influencing EDNRB

Yuye Wang,
Qing Ma,
Meitong Chen,
Yukako Kayashima and ,
Jiayi Zhou,
Balaji Rao,
Jessica L. Bowser,
Xianwen Yi,
Nobuyo Maeda-Smithies and
Feng Li
+ 5 authors+ 0 author

Cells2025, 14(21), 1645;https://doi.org/10.3390/cells14211645

22 October 2025

Endothelin-1 (ET-1) is involved in the pathogenesis of preeclampsia. Mice (Edn1^H/+) having excess endothelin-1 developed preeclampsia-like phenotypes during pregnancy in a maternal genotype-dependent manner. Here, we investigated whether decidualizat...

(This article belongs to the Special Issue Cellular and Molecular Mechanisms of Vascular-Related Diseases)

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1 Citations

1,060 Views

12 Pages

A Hypothetical Energy-Dissipating Mechanism Regulated by Glucose in β-Cells Preceding Sustained Insulin Secretion

Jorge Tamarit-Rodriguez

Cells2025, 14(21), 1644;https://doi.org/10.3390/cells14211644

22 October 2025

In this review we propose the hypothesis that an energy-dissipating process precedes the continuous stimulation of insulin secretion by glucose. This process is mediated by connexin 36 hemichannels (Cx36H), or Cx36 connexons. Cx36H oligomers are expr...

(This article belongs to the Section Cellular Metabolism)

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Cells - ISSN 2073-4409

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