Cancers, Volume 15, Issue 12
June-2 2023 - 200 articles
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Cover Story: A high level of programmed death ligand-1 (PD-L1) promotes an immune-depleted (“cold”) tumour microenvironment and is a key factor in immune evasion and aggressive growth of glioblastoma (GBM). It is well recognised that PD-L1 expression is a critical biomarker to predict which patients will respond to PD-1/PD-L1 checkpoint inhibitors; however, it is subjected to spatial and temporal heterogeneity. This underscores the need to monitor PD-L1 distribution over time through real-time immuno-PET imaging. We believe that molecular imaging of this target has great potential to stratify patients accurately and quantitatively for immunotherapy, offering a practical remedy to the drawbacks of conventional techniques such as biopsy and immunohistochemistry staining. View this paper 
