Table of Contents
Cancers, Volume 10, Issue 10 (October 2018)
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Cover Story (view full-size image) Tumor cells take advantage of cell stress response pathways to enable their survival under adverse [...] Read more. Tumor cells take advantage of cell stress response pathways to enable their survival under adverse conditions. In breast cancer cells, constitutive activation of unfolded protein response (UPR) promotes an adaptive, therapy-resistant phenotype. This UPR-dependence exposes a weakness in breast cancer cells that can be exploited for therapeutic purposes. The UPR is mediated by signalling through three transmembrane ER stress sensors, IRE1, PERK and ATF6. Several novel drugs that target these pathways, particularly the IRE1 pathway, show promise in preclinical studies, supporting the case for their clinical development. View this paper