Table of Contents
Cancers, Volume 10, Issue 9 (September 2018)
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Cover Story (view full-size image) MicroRNA-based therapeutics have gained prominence as a cancer therapy due to their multiple [...] Read more. MicroRNA-based therapeutics have gained prominence as a cancer therapy due to their multiple targeting abilities. However, their rapid degradation in serum and low cellular internalization makes them ineffective for treatment. This study reports an efficient nanoplatform that delivers microRNA (we chose miR-205) to prostate cancer cells. Our nanoformulation (MPEI-PEG) efficiently delivered miRNA-205 and suppressed cell growth and the metastasis of cancer cells. Further, it selectively inhibited P-gp/MDR1 and thus prevented the drug efflux causing the intracellular drug accumulation of chemotherapy drugs. Overall, this data is evidence of the chemo-sensitizing ability of miR-205 nanoformulation for chemotherapy. View this paper