Accelerated Hypofractionated Active Raster-Scanned Carbon Ion Radiotherapy (CIRT) for Laryngeal Malignancies: Feasibility and Safety
Abstract
:1. Introduction
2. Results
2.1. Survival Analysis
2.2. Acute Toxicity
2.3. Chronic Toxicity
3. Discussion
4. Materials and Methods
4.1. Treatment Planning
4.2. Follow-up
4.3. Analysis
4.4. Patient, Disease, and Treatment Characteristics
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Characteristic | Acute Toxicity, No. (%) | Chronic Toxicity, No. (%) | ||||
---|---|---|---|---|---|---|
(n = 15) | C12 Alone (n = 7) | IMRT + C12 (n = 8) | Total (n = 15) | C12 Alone (n = 7) | IMRT + C12 (n = 8) | Total (n = 15) |
overall toxicity | ||||||
grade 1 | 3 (43) | 2 (25) | 5 (33) | 2 (29) | 3 (38) | 5 (33) |
grade 2 | 2 (29) | 4 (50) | 6 (40) | 2 (29) | 1 (13) | 3 (20) |
grade 3 | 2 (29) | 2 (25) | 4 (27) | 1 (14) | 0 | 1 (7) |
grade 4 | 0 | 0 | 0 | 0 | 0 | 0 |
dysphagia | ||||||
grade 1 | 3 (43) | 3 (38) | 6 (40) | 3 (43) | 0 | n = 3 (20) |
grade 2 | 1 (14) | 2 (25) | 3 (20) | 1 (14) | 0 | n = 1 (7) |
grade 3 | 1 (14) | 1 (13) | 2 (13) | 0 | 0 | 0 |
odynophagia | ||||||
grade 1 | 4 (57) | 3 (38) | 7 (53) | 0 | 0 | 0 |
grade 2 | 1 (14) | 1 (13) | 2 (13) | 0 | 0 | 0 |
grade 3 | 2 (29) | 1 (13) | 3 (20) | 0 | 0 | 0 |
mucositis | ||||||
grade 1 | 2 (29) | 0 | 2 (13) | 0 | 0 | 0 |
grade 2 | 1 (14) | 3 (38) | 2 (13) | 0 | 0 | 0 |
dermatitis | ||||||
grade 1 | 3 (43) | 3 38 () | 6 (40) | 0 | 0 | 0 |
grade 2 | 0 | 3 (38) | 3 (20) | 0 | 0 | 0 |
xerostomia | ||||||
grade 1 | 3 (43) | 4 (50) | 7 (53) | 5 (71) | 3 (38) | 8 (53) |
grade 2 | 1 (14) | 0 | 1 (7) | 0 | 3 (38) | 3 (20) |
hoarseness | ||||||
grade 1 | 2 (29) | 3 (38) | 5 (33) | 2 (29) | 3 (38) | 5 (33) |
grade 2 | 2 (29) | 1 (13) | 3 (20) | 2 (29) | 1 (13) | 3 (20) |
grade 3 | 0 | 0 | 0 | 1 (14) | 0 | 1 (7) |
fatigue | ||||||
grade 1 | 0 | 2 (25) | 2 (13) | 2 (29) | 1 (13) | 3 (20) |
grade 2 | 4 (57) | 0 | 4 (27) | 1 (14) | 0 | 1 (7) |
grade 3 | 0 | 1 (13) | 1 (7) | 0 | 0 | 0 |
dysgeusia | ||||||
grade 1 | 0 | 2 (25) | 2 (13) | 1 (14) | 1 (13) | 2 (13) |
grade 2 | 0 | 2 (25) | 2 (13) | 0 | 0 | 0 |
alopecia | ||||||
grade 1 | 3 (43) | 2 (25) | 5 (33) | 0 | 0 | 0 |
dry cough | ||||||
grade 1 | 1 (14) | 1 (13) | 2 (13) | 0 | 0 | 0 |
Characteristic | C12 Alone, n = 7 No. (%) | C12 + IMRT, n = 8 No. (%) | Total, n = 15 No. (%) |
---|---|---|---|
median age | 61 years (55–73 years) | 58 years (21–68 years) | 61 years (21–73 years) |
median follow-up | 22 months (9–48 months) | 24 months (8–61 months) | 24 months (8–61 months) |
gender | |||
male | 3 (43) | 4 (50) | 7 (47) |
female | 4 (57) | 4 (50) | 8 (53) |
WHO performance status | |||
0 | 4 (57) | 4 50 () | 8 (53) |
1 | 3 (43) | 3 (38) | 6 (40) |
2 | 0 | 1 (12) | 1 (7) |
tumor type | |||
ACC | 0 | 8 (100) | 8 (53) |
CS | 7 (100) | 0 | 7 (47) |
tumor site | |||
glottic larynx | 2 (29) | 4 (50) | 7 (47) |
subglottic larynx | 1 (14) | 0 | 1 (7) |
supraglottic larynx | 4 (57) | 4 (50) | 7 (47) |
initial T stage | |||
T1 | 2 (29) | 1 (12) | 3 (20) |
T2 | 1 (14) | 1 (12) | 2 (13) |
T3 | 2 (29) | 0 | 2 (13) |
T4a | 1 (14) | 5 (63) | 6 (40) |
T4b | 1 (14) | 1 (12) | 2 (13) |
initial N stage | |||
N0 | 7 (100) | 8 (100) | 15 (100) |
N+ | 0 | 0 | 0 |
initial M stage | |||
M1 | 7 (100) | 8 (100) | 15 (100) |
M0 | 0 | 0 | 0 |
treatment | |||
RT only | 3 (43) | 6 (75) | 9 (60) |
postop. RT | 4 (57) | 2 (25) | 6 (40) |
total laryngectomy | 0 | 1 (12) | 1 (7) |
laser surgical resection | 4 (57) | 1 (12) | 5 (33) |
concomitant cetuximab | 0 | 1 (12) | 1 (7) |
median EQD2 in Gy | 75 Gy (75–75 Gy) | 76.25 Gy (72.5–80 Gy) | 75 Gy (72.5–80 Gy) |
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Share and Cite
Akbaba, S.; Lang, K.; Held, T.; Bulut, O.C.; Mattke, M.; Uhl, M.; Jensen, A.; Plinkert, P.; Rieken, S.; Herfarth, K.; et al. Accelerated Hypofractionated Active Raster-Scanned Carbon Ion Radiotherapy (CIRT) for Laryngeal Malignancies: Feasibility and Safety. Cancers 2018, 10, 388. https://doi.org/10.3390/cancers10100388
Akbaba S, Lang K, Held T, Bulut OC, Mattke M, Uhl M, Jensen A, Plinkert P, Rieken S, Herfarth K, et al. Accelerated Hypofractionated Active Raster-Scanned Carbon Ion Radiotherapy (CIRT) for Laryngeal Malignancies: Feasibility and Safety. Cancers. 2018; 10(10):388. https://doi.org/10.3390/cancers10100388
Chicago/Turabian StyleAkbaba, Sati, Kristin Lang, Thomas Held, Olcay Cem Bulut, Matthias Mattke, Matthias Uhl, Alexandra Jensen, Peter Plinkert, Stefan Rieken, Klaus Herfarth, and et al. 2018. "Accelerated Hypofractionated Active Raster-Scanned Carbon Ion Radiotherapy (CIRT) for Laryngeal Malignancies: Feasibility and Safety" Cancers 10, no. 10: 388. https://doi.org/10.3390/cancers10100388