Special Issue "Gap Junctions and Connexins in Cancer Formation, Progression, and Therapy"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (31 December 2018)
Gap junctions are clusters of aqueous channels approximately 1.5 nm in diameter that directly connect the interiors of two apposed cells. The channels enable cell-to-cell diffusion of small molecules and ions (e.g., water, amino acids, simple sugars, second messengers, and microRNAs), but not larger, more complex molecules. The channels are comprised of connexins, of which twenty human forms are known.
Cancer cells typically have defects in gap junctions for many reasons that include deficient expression of connexins, defective connexin trafficking, and poor cell–cell adhesion. The restoration of gap junctions in many types of neoplastic cells normalizes their phenotype (decreased proliferation and tumorigenicity and increased sensitivity to therapy). Connexins also have functions independent of channel formation and can play roles in signal transduction and gene transcription. Some connexins may also enhance invasion and metastasis. Newer studies also suggest connexins impact cancer stem cell number and function and cancer cell dormancy. This Special Issue will highlight recent findings on the many roles of gap junctions and connexins in cancer development, progression, and therapeutic response.
Dr. Randall J. Ruch
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- gap junctions
- intercellular communication
- tumor microenvironment
- cancer dormancy
- cancer stem cells
- tumor promotion