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Cancers 2018, 10(10), 381;

Involving the microRNA Targetome in Esophageal-Cancer Development and Behavior

Molecular Oncology and Viral Pathology Group, IPO-Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO-Porto), Rua Dr António Bernardino de Almeida, 4200-072 Porto, Portugal
Abel Salazar Institute for the Biomedical Sciences (ICBAS), University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal
Research Department, LPCC—Portuguease League against Cancer (NRN Norte), Estrada Interior da Circunvalação 6657, 4200-172 Porto, Portugal
Faculty of Medicine, University of Porto (FMUP), Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal
CEBIMED, Faculty of Health Sciences, Fernando Pessoa University, Praça de 9 de Abril 349, 4249-004 Porto, Portugal
Authors to whom correspondence should be addressed.
Received: 30 August 2018 / Revised: 9 October 2018 / Accepted: 10 October 2018 / Published: 12 October 2018
(This article belongs to the Special Issue MicroRNA-Associated Cancer Metastasis)
PDF [631 KB, uploaded 12 October 2018]


Esophageal cancer (EC) is the eighth most common and sixth leading cause of cancer-related mortality in the world. Despite breakthroughs in EC diagnosis and treatment, patients with complete pathologic response after being submitted to chemoradiotherapy are still submitted to surgery, despite its high morbidity. Single-nucleotide polymorphisms (SNPs) in miRNA, miRNA-binding sites, and in its biogenesis pathway genes can alter miRNA expression patterns, thereby influencing cancer risk and prognosis. In this review, we systematized the information available regarding the impact of these miR-SNPs in EC development and prognosis. We found 34 miR-SNPs that were associated with EC risk. Despite the promising applicability of these miR-SNPs as disease biomarkers, they still lack validation in non-Asian populations. Moreover, there should be more pathway-based approaches to evaluate the cumulative effect of multiple unfavorable genotypes and, consequently, identify miR-SNPs signatures capable of predicting EC therapy response and prognosis. View Full-Text
Keywords: esophageal cancer; miR-SNPs; molecular biomarkers esophageal cancer; miR-SNPs; molecular biomarkers

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Dias, F.; Morais, M.; Teixeira, A.L.; Medeiros, R. Involving the microRNA Targetome in Esophageal-Cancer Development and Behavior. Cancers 2018, 10, 381.

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